Rational design of flexible microneedles coupled with CaO₂@PDA-loaded nanofiber films for skin wound healing on diabetic rats

Abstract

Skin ulcers is one of the complications of diabetes. At present, the treatment of diabetic skin wound is still not satisfactory, and the efficiency of drug delivery is limited by the depth...

Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars

“…This personalized microneedle patch system opens a new window for management and treatment of skin diseases such as HSs, keloid, closed wounds, cutaneous melanoma, and so on. In the future, flexible microneedles 18,54 can be designed for better adhesion to HS tissues. Moreover, a combined strategy, such as Mepiform® soft silicone sheeting for physical treatment dressing and drug-loaded microneedles for scar treatment, can be used for improved performance in scar management.…”

“…Microneedles (MNs) represent a novel technology for drug delivery. [6][7][8] With micrometer-scaled needles arranged in a designed patch, the microneedle patch system has advantages such as minimal invasion and personalized and precise drug release and has attracted emerging attention in biosensing, 9,10 diagnosis, 11 and treatments of different diseases including diabetes, [12][13][14] cancers, 15,16 wounds, [17][18][19] scars, [20][21][22] and psoriasis. 23 The stratum corneum is the main barrier of the skin and limits the efficiency of transdermal drug penetration.…”

Porcupine-inspired microneedles coupled with an adhesive back patching as dressing for accelerating diabetic wound healing

“…Because of their good structural and excellent loading capacity compare with general drug delivery carriers, MN patches can effectively realize the loading of bioactive substances such as macromolecular drugs [14] , cells [15] , vaccines [16] and so on. And different strategies are currently being applied in diabetes wound healing by MN patches, 1) control the blood glucose and take care of wounds [17] , 2) antibacterial effect by loading traditional Chinese herb [18] or nanoparticles [19] and photothermal therapy (PTT) [20] , 3) scavenging reactive oxygen species (ROS) [21] . However, general MN patches could not adhere well to the skin tissue and would fall off from the skin easily due to its elasticity and mobility [22] .…”

Microneedles for in situ tissue regeneration

“…In particular, approximately 15–25% of diabetes will develop a diabetic foot ulcer (DFU) during their lifetime [ 92 , 116 ]. DFU is often accompanied by persistent inflammation, bacterial infection, poor angiogenesis and tissue regeneration, making it often difficult to cure DFU with traditional treatment [ 117 , 118 ]. As illustrated in Fig.…”