Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy

Coordination compounds in cancer: Past, present and perspectives

“…Recently, Au(III)-peptide-dithiocarbamate complexes with general formula [AuX 2 (pdtc)] (X = Cl, Br; pdtc = oligopeptidedithiocarbamate) (Fig. 15f) have been synthesized using di-, tri-, tetra-and pentapeptides (Kouodom et al, 2012). The incorporation of peptides makes the complex recognizable by intracellular peptide transporters (PEPTs).…”

“…They also show no crossresistance with cisplatin, confirming a different cytotoxic mechanism. The study of in vivo activity and mechanism started recently (Kouodom et al, 2012).…”

Oxidation of methionine residue in Gly-Met dipeptide induced by [Au(en)Cl2]+ and influence of the chelated ligand on the rate of this redox process

“…Some gold(I) complexes, such as auranofin and aurothiomalate, have been used very successfully in the treatment of rheumatoid arthritis [2], while gold(III) complexes have gained considerable attention as potential antitumor agents [3]. During the recent years, a large number of gold(III) complexes, in which the reduction potential of the Au(III) was lowered by the use of polydentate ligands, have been reported to be appreciably stable under physiologically relevant conditions and to manifest relevant cytotoxic activity against different human tumor cell lines [4][5][6][7][8][9][10][11][12][13][14][15][16]. The possible involvement of gold(III) complexes in cancer treatment initiated an interest in the area of gold(III) interactions with different biologically important ligands, such as amino acids and peptides [17].…”

Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework

“…Unlike the clinically-used platinum (II) drugs which target DNA to execute their cytotoxic activities, many gold(III) dithiocarbamato complexes were found capable to induce cancer apoptotic cell death via inhibition of thioredoxin redox system and proteasomes, and activation of ERK pathway [22][23][24][25]. Various peptidomimetic gold(III) dithiocarbamato complexes show enhancing anti-cancer activities and cancer-cell selectivity in vitro [26,27] [28]. These complexes were found to undergo extensive hydrolysis in aqueous medium, which in turn affects their cytotoxic activities against the cancer cells.…”