Rational Design of Ion Exchange Simulated Moving Bed Processes

Fechtner, Marcus; Kienle, Achim

doi:10.1016/b978-0-12-823377-1.50123-3

Cited by 3 publications

(7 citation statements)

References 7 publications

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“…[27][28][29][30] For nonconstant selectivity, the lines for constructing the triangular diagram can be determined numerically. 6,16,18,24 3 | METHODS…”

Section: System Descriptionmentioning

confidence: 99%

“…16,17 These shortcut design methods can reduce the complexity and the computational efforts to determine optimal operating conditions for the SMB. 6,[16][17][18] Migliorini et al 16 proposed a versatile shortcut design method applicable to any isotherm; however, the application of the method to gradient SMB or multicomponent systems is less clear. Instead, the focus is on the isocratic operation of the SMB.…”

Section: Introductionmentioning

confidence: 99%

“…These constraints allow for the computation of operational flow rate ratios for each TMB section, which can then be transformed into SMB flow rates 16,17 . These shortcut design methods can reduce the complexity and the computational efforts to determine optimal operating conditions for the SMB 6,16–18 …”

Section: Introductionmentioning

confidence: 99%

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Shortcut design method for multicomponent gradient simulated moving beds

Frandsen,

Huusom,

Gernaey

et al. 2023

AIChE Journal

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This work describes a method for design (and verification) of isocratic and gradient simulated moving bed (SMB) chromatography, based on the triangle theory. The method is tested using both constant selectivity and nonconstant selectivity isotherms as well as implicit and explicit isotherms through the Linear, Langmuir, and SMA isotherms. The results show that the method is applicable to a wide range of isotherms and to multicomponent systems. The study also investigates the influence of modifier concentrations on gradient SMB performance, by determining the optimal flow rate ratios for calculating volume‐specific productivity and eluent consumption. These findings demonstrate the potential of the method to improve the performance of a gradient SMB and serve as a useful initial step in the design and optimization of operational flow rates and modifier concentrations.

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“…[27][28][29][30] For nonconstant selectivity, the lines for constructing the triangular diagram can be determined numerically. 6,16,18,24 3 | METHODS…”

Section: System Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Shortcut design method for multicomponent gradient simulated moving beds

Frandsen,

Huusom,

Gernaey

et al. 2023

AIChE Journal

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show abstract

“…16 More recently Fechtner and Kienle discussed equilibrium theory for stoichiometric ion exchange with an implicit sorption isotherm 17 and extended triangle theory to ion exchange SMB processes. 18 The main outcome of the analysis based on the equilibrium theory is the identification of regions for dimensionless flowrate ratios in the four zones. In particular, the specification of suitable flow-rates in the two separation zones 2 and 3 is most relevant.…”

Section: Introductionmentioning

confidence: 99%

“…Solutions for a very flexible extension to a generalized Langmuir isotherm model are also available . More recently Fechtner and Kienle discussed equilibrium theory for stoichiometric ion exchange with an implicit sorption isotherm and extended triangle theory to ion exchange SMB processes …”

Section: Introductionmentioning

confidence: 99%

Numerical Short-Cut Design of Simulated Moving Bed Chromatography for Multicomponent Nonlinear Adsorption Isotherms: Nonstoichiometric Langmuir Model

Lee

Kienle

Seidel‐Morgenstern

2021

Ind. Eng. Chem. Res.

Self Cite

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For the fine chemical and pharmaceutical industries, simulated moving bed (SMB) chromatography is a very promising separation process. Because of its structural and operational complexity this periodically operated multicolumn process is not easy to design and optimize. In the 1990s, Storti, Mazzotti, and Morbidelli exploited the potential of the equilibrium theory and developed a now well-established short-cut design method for the conventional four-zone SMB processes. The concept, which is known as the “triangle theory”, provides explicit design rules for a small set of nonlinear adsorption isotherm models and the case of processing binary feed mixtures. For the sake of extending the triangle theory to multicomponent systems, we introduce in this work a numerical short-cut method. The iterative method will be illustrated to design a conventional four-zone SMB process for the separation of quaternary mixtures obeying nonstoichiometric Langmuir isotherms. The results will be validated by comparing predicted internal concentration profiles with the results of additionally carried out true moving bed simulations.

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Unified design of chromatographic separation processes: Partial separations and waste fractions

Sainio

2021

Chemical Engineering Science

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Rational Design of Ion Exchange Simulated Moving Bed Processes

Cited by 3 publications

References 7 publications

Shortcut design method for multicomponent gradient simulated moving beds

Shortcut design method for multicomponent gradient simulated moving beds

Numerical Short-Cut Design of Simulated Moving Bed Chromatography for Multicomponent Nonlinear Adsorption Isotherms: Nonstoichiometric Langmuir Model

Unified design of chromatographic separation processes: Partial separations and waste fractions

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