Rational design of mesoporous chiral MOFs as reactive pockets in nanochannels for enzyme-free identification of monosaccharide enantiomers

Abstract

Monosaccharides play significant roles in daily metabolism in living organisms. Although various devices have been constructed for monosaccharide identification, most rely on the specificity of the natural enzyme. Herein, inspired...

Homochiral Zeolitic Imidazolate Framework with Defined Chiral Microenvironment for Electrochemical Enantioselective Recognition

“…[2,3] Up to now, chiral recognition has long been challenging owing to the extreme similarity of two enantiomers. [4,5] With the emergence of new types of chiral materials (e.g., upconversion nanoparticle, [6] chiral nanostructured Au films, [7] chiral pillar [n] arene, [8][9][10] and chiral copper selenide nanoparticles [11] ), chiral recognition technologies have made great progress in the past integratability, [29,30] showing great potential as a platform for chiral recognition.…”

“…Chromatography and optical methods (e.g., circular dichroism, fluorescence and Raman spectroscopies), as widely used chiral recognition techniques, usually require high‐cost chiral chromatography columns or expensive apparatuses, and sometimes need complex sample pretreatments. [ 28 ] In contrast, nanopore‐based electrochemical methods exhibit advantages of simple sample pretreatment, low‐cost instruments, high sensitivity, and high integratability, [ 29,30 ] showing great potential as a platform for chiral recognition.…”

Defect-Rich CoFe-Layered Double Hydroxides as Superior Peroxidase-like Nanozymes for the Detection of Ascorbic Acid

“…Nanozymes are a new class of artificial enzyme mimics with intrinsic enzyme-like properties . Compared with natural enzymes, inorganic nanomaterial-based nanozymes have become a focus of attention due to their high stability, low cost, adaptability to harsh environments, and easy regulation of catalytic activity. − In recent years, inorganic nanomaterials have been widely used as nanozymes in colorimetry/fluorometry or electrochemical detection of small molecules or biomolecules. − Peroxidases (PODs) are a class of enzymes in living organisms that use H 2 O 2 as a substrate. It can not only eliminate H 2 O 2 but also catalyze the oxidation reaction of H 2 O 2 with other harmful substrates (such as phenols and amines), playing the dual role of scavenging reactive oxygen species and oxidative detoxification of toxic substances .…”

Target Recognition-Triggered Peroxidase-Mimicking Activity Depression in Homochiral Nanochannels for Identifying Cystine Enantiomers

“…MOFs are considered ideal candidates for the fabrication of superior sensing elements by benefitting from a regular 3D structure, high porosity, highly tunable framework structures, and versatile signal transductions. Although some chiral MOFs have been successfully applied in enantioselective recognition, , further exploitation of this field is still very limited. The elevated difficulties in seeking for suitable chiral ligands and complicated synthesis restrict the development of the research of chiral MOFs.…”