Rational design of yolk–shell nanostructures for drug delivery

Ziarani, Ghodsi Mohammadi; Mofatehnia, Parisa; Mohajer, Fatemeh; Badiei, Alireza

doi:10.1039/d0ra03611k

Cited by 16 publications

(7 citation statements)

References 67 publications

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“…Furthermore, considering the low toxicity and biodegradability of ZnO, ZnO materials have been studied for biomedical applications [17] . Due to the hollow cavity of yolk‐shell structures, yolk‐shell structures have been applied as drug delivery systems [41] and are a prospective approach for active drug delivery applications.…”

Section: Discussionmentioning

confidence: 99%

Self‐Asymmetric Yolk–Shell Photocatalytic ZnO Micromotors

2021

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Large‐scale fabrication of self‐propelled micromotors is crucial to reach practical applications, but batch processes in manufacture make it challenging. Here, a novel ZnO yolk‐shell structure from large‐scale synthesis is introduced as photocatalytic micromotor. The self‐asymmetry of the yolk‐shell structure enables them to create asymmetric gradients, leading to autonomous motion. Benefiting from the inner void space, the ZnO micromotors possess higher incident light utilization and a larger surface area for photocatalytic reactions. Moreover, when exposed to hydrogen peroxide, ZnO partially transforms into ZnO2 forming a beneficial ZnO2/ZnO heterojunction for separation of photo‐generated carriers, enhancing the photochemical reactions and thereby the motion. This combination of yolk‐shell structure and ZnO2/ZnO heterojunction formation provides a prospective approach for large‐scale asymmetric micromotor fabrication and may open new horizons for designing versatile photocatalytic micromotors.

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Section: Discussionmentioning

confidence: 99%

Self‐Asymmetric Yolk–Shell Photocatalytic ZnO Micromotors

2021

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“…Today, the development of nanotechnology has resulted in the creation of several multidisciplinary research domains, namely bionanotechnology, with special contributions in biomedicine and cancer nanomedicine [ 1 , 2 , 3 , 4 , 5 , 6 ]. An assortment of nanoparticles and nanoarchitectures has been designed with satisfactory biocompatibility and targeting properties for a wide range of biomedical and clinical applications; however, due to the stringent regulatory necessities, only a handful of them have entered into clinical trials/studies.…”

Section: Introductionmentioning

confidence: 99%

Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy

et al. 2022

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MXenes with unique mechanical, optical, electronic, and thermal properties along with a specific large surface area for surface functionalization/modification, high electrical conductivity, magnetic properties, biocompatibility, and low toxicity have been explored as attractive candidates for the targeted delivery of drugs in cancer therapy. These two-dimensional materials have garnered much attention in the field of cancer therapy since they have shown suitable photothermal effects, biocompatibility, and luminescence properties. However, outstanding challenging issues regarding their pharmacokinetics, biosafety, targeting properties, optimized functionalization, synthesis/reaction conditions, and clinical translational studies still need to be addressed. Herein, recent advances and upcoming challenges in the design of advanced targeted drug delivery micro- and nanosystems in cancer therapy using MXenes have been discussed to motivate researchers to further investigate this field of science.

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“…In continuation of our research work, 51–54 herein, an overview of waste-assisted efforts in inherently sustainable multi-component reactions has been elaborated.…”

Section: Introductionmentioning

confidence: 99%