“…Fear of fatness or fear of weight gain has been considered to be a key feature of AN, yet family, twin and genetic studies have little to say about the underlying biology of the symptom. Hebebrand et al 18 underscore the lack of reliability and validity of this criterion, difficulty with measurement, absence in non-Western cultures, 38,39 failure to reflect the biology of AN, 40,41 and fluctuations over the course of AN. 42,43 Thus, this criterion is best conceptualized as an environmental feature relevant to understanding maintenance factors for AN, for predicting clinical course, and for understanding cultural manifestations, 44 but not a candidate endophenotype reflective of a core underlying biological process.…”