Rationally designed bimetallic Au@Pt nanoparticles for glucose oxidation

Shim, Kyubin; Lee, Won‐Chul; Heo, Yoon-Uk; Shahabuddin, Mohammed; Park, Min; Hossain, Md. Shahriar A.; Kim, Jung Ho

doi:10.1038/s41598-018-36759-5

Cited by 37 publications

(21 citation statements)

References 37 publications

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“…These structural findings were confirmed by analysis of XRD standard Bragg reflections (Fig. 2b), which could be assigned to fcc gold and fcc platinum [20–22]. The calculated lattice constants (a Au = 4.076 Å and a Pt = 3.922 Å with uncertainties ~ 0.001 Å) were in a good agreement with lattice constants of Au and Pt nanoparticles known from the literature [23, 24].…”

Section: Resultssupporting

confidence: 80%

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Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

Depciuch¹,

Stec²,

Klębowski³

et al. 2019

J Nanobiotechnol

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Background New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT. Results Light microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation combined with PtAu NRs caused visible changes in the cell morphology. Fourier Transform InfraRed (FTIR) and Raman spectroscopies showed chemical changes in the DNA, phospholipids, lipids and protein structures caused by laser irradiation in the presence of PtAu NRs. The MTS assay showed ~ 25% mortality of cancer cells due to the addition of PtAu NRs to the cell culture, while for laser irradiation combined with nanoparticles, the mortality of cancer cells increased to 65% for the 650 nm laser and to 60% for the 808 nm laser. The calculated photothermal conversion efficiency reached 62% and 51% for the 650 nm and 808 nm lasers, respectively. Conclusions PtAu NRs could be applied as effective light-absorbers in the PTT anticancer therapy.

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Section: Resultssupporting

confidence: 80%

“…The rings on SAED (Fig. 2a) patterns could be attributed to the (111), (200), (220), (311) and (222) lattice planes of Au and Pt nanocrystals with face-centered cubic lattice [20]. Due to the large size of the Pt NPs (> 140 nm), the SAED pattern should contain some spots, however it is formed of well-defined, continuous rings.…”

Section: Resultsmentioning

confidence: 99%

Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

Depciuch¹,

Stec²,

Klębowski³

et al. 2019

J Nanobiotechnol

View full text Add to dashboard Cite

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“…The surface Pt-rich bimetallic nanocatalysts with different Au/Pt atomic ratios have demonstrated enhanced hydrogenation selectivity or activity than AuPt alloys and monometallic Pt nanomaterials [20,21]. In addition, Au@Pt NPs showed the highest response current for the catalytic oxidation of glucose solution compared with those of Pt and Au NPs [22,23]. Recent theoretical predictions showed that the PtAu surface avoids the CO formation and apparently exhibits higher CO-poisoning tolerance when compared with the Pt@Pd surface [24].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Au@Pt Core—Shell Nanoparticles as Efficient Electrocatalyst for Methanol Electro-Oxidation

et al. 2019

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Bimetallic Au@Pt nanoparticles (NPs) with Pt monolayer shell are of much interest for applications in heterogeneous catalysts because of enhanced catalytic activity and very low Pt-utilization. However, precisely controlled synthesis with uniform Pt-monolayers and stability on the AuNPs seeds remain elusive. Herein, we report the controlled deposition of Pt-monolayer onto uniform AuNPs seeds to obtain Au@Pt core–shell NPs and their Pt-coverage dependent electrocatalytic activity for methanol electro-oxidation. The atomic ratio between Au/Pt was effectively tuned by varying the precursor solution ratio in the reaction solution. The morphology and atomic structure of the Au@Pt NPs were analyzed by high-resolution scanning transmission electron microcopy (HR-STEM) and X-ray diffraction (XRD) techniques. The results demonstrated that the Au@Pt core–shell NPs with Pt-shell thickness (atomic ratio 1:2) exhibit higher electrocatalytic activity for methanol electro-oxidation reaction, whereas higher and lower Pt ratios showed less overall catalytic performance. Such higher catalytic performance of Au@Pt NPs (1:2) can be attributed to the weakened CO binding on the Pt/monolayers surface. Our present synthesis strategy and optimization of the catalytic activity of Au@Pt core–shell NPs catalysts provide promising approach to rationally design highly active catalysts with less Pt-usage for high performance electrocatalysts for applications in fuel cells.

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“…From the SAED pattern, it was found that the obtained AuPt NCs have a crystalline structure (sharp diffraction rings with bright spots were observed). The diffraction rings ( Figure 3 d) could be attributed to the (111), (200), (220), and (311) lattice planes of Au and Pt nanocrystals crystalized in the face-centered cubic structure [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Fancy-Shaped Gold–Platinum Nanocauliflowers for Improved Proton Irradiation Effect on Colon Cancer Cells

Klębowski

Depciuch

Stec

et al. 2020

IJMS

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Enhancing the effectiveness of colorectal cancer treatment is highly desirable. Radiation-based anticancer therapy—such as proton therapy (PT)—can be used to shrink tumors before subsequent surgical intervention; therefore, improving the effectiveness of this treatment is crucial. The addition of noble metal nanoparticles (NPs), acting as radiosensitizers, increases the PT therapeutic effect. Thus, in this paper, the effect of novel, gold–platinum nanocauliflowers (AuPt NCs) on PT efficiency is determined. For this purpose, crystalline, 66-nm fancy shaped, bimetallic AuPt NCs were synthesized using green chemistry method. Then, physicochemical characterization of the obtained AuPt NCs by transmission electron microscopy (TEM), selected area electron diffraction (SAED), energy dispersive X-ray spectroscopy (EDS), and UV-Vis spectra measurements was carried out. Fully characterized AuPt NCs were placed into a cell culture of colon cancer cell lines (HCT116, SW480, and SW620) and a normal colon cell line (FHC) and subsequently subjected to proton irradiation with a total dose of 15 Gy. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) test, performed after 18-h incubation of the irradiated cell culture with AuPt NCs, showed a significant reduction in cancer cell viability compared to normal cells. Thus, the radio-enhancing features of AuPt NCs indicate their potential application for the improvement in effectiveness of anticancer proton therapy.

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Rationally designed bimetallic Au@Pt nanoparticles for glucose oxidation

Cited by 37 publications

References 37 publications

Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

Synthesis of Au@Pt Core—Shell Nanoparticles as Efficient Electrocatalyst for Methanol Electro-Oxidation

Fancy-Shaped Gold–Platinum Nanocauliflowers for Improved Proton Irradiation Effect on Colon Cancer Cells

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