Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer

Sen, Sajal; Hufnagel, Stephanie; Maier, Esther Y.; Aguilar, Isaiah; Selvakumar, Jayaraman; DeVore, Jennie E.; Lynch, Vincent M.; Arumugam, Kuppuswamy; Cui, Zhengrong; Sessler, Jonathan L.; Arambula, Jonathan F.

doi:10.1021/jacs.0c09753

Cited by 73 publications

(77 citation statements)

References 38 publications

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“…Accumulating studies have combined nanoparticles with immunoadjuvants, chemotherapeutics, photodynamic therapy, or again photothermal therapy in order to reshape the tumor hypoxic microenvironment to elicit or enhance ICD (81,82). These novel nanoparticles synergized with IR and enhanced antitumor immune function (83)(84)(85)(86)(87). Qian Chen et al confirmed that PLGA-R837@Cat nanoparticle-based x-ray radiation inhibited primary tumors significantly in comparison with RT alone.…”

Section: The Methods Of Enhancing Ir-induced Icdmentioning

confidence: 99%

Immunogenic Cell Death Induction by Ionizing Radiation

et al. 2021

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Immunogenic cell death (ICD) is a form of regulated cell death (RCD) induced by various stresses and produces antitumor immunity via damage-associated molecular patterns (DAMPs) release or exposure, mainly including high mobility group box 1 (HMGB1), calreticulin (CRT), adenosine triphosphate (ATP), and heat shock proteins (HSPs). Emerging evidence has suggested that ionizing radiation (IR) can induce ICD, and the dose, type, and fractionation of irradiation influence the induction of ICD. At present, IR-induced ICD is mainly verified in vitro in mice and there is few clinical evidence about it. To boost the induction of ICD by IR, some strategies have shown synergy with IR to enhance antitumor immune response, such as hyperthermia, nanoparticles, and chemotherapy. In this review, we focus on the molecular mechanisms of ICD, ICD-promoting factors associated with irradiation, the clinical evidence of ICD, and immunogenic forms of cell death. Finally, we summarize various methods of improving ICD induced by IR.

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Section: The Methods Of Enhancing Ir-induced Icdmentioning

confidence: 99%

Immunogenic Cell Death Induction by Ionizing Radiation

et al. 2021

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“…In 2021, Arambula et al 58 reported a rationally designed redox-active Au( i ) bis N-heterocyclic carbene (NHC) compound 2.13 (Fig. 19A) that can induce ICD both in vitro and in vivo .…”

Section: Metal Based Complexes As Icd Inducersmentioning

confidence: 99%

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

et al. 2022

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“…Fourth, co-loading multi-components on nanoparticles could significantly improve ICD and anti-tumor effect. Sen et al engineered a redox-active Au(I) bis-N-heterocyclic carbine (Au(I) bis-NHC) that realized the double effect combining TrxR2 inhibition (damaging biological antioxidants) with increased oxidative stress [ 80 ]. The combination of photodynamic therapy with oxygen therapy based on C@HPOC showed enhanced specific CD8 + T cell response and abscopal effect [ 66 ].…”

Section: Improving Tumor Immunogenicitymentioning

confidence: 99%

Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies

et al. 2021

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Therapies mobilizing host immunity against cancer cells have profoundly improved prognosis of cancer patients. However, efficacy of immunotherapies depends on local immune conditions. The “cold” tumor, which is characterized by lacking inflamed T cells, is insensitive to immunotherapy. Current strategies of improving the “cold” tumor microenvironment are far from satisfying. Nanoparticle-based therapies provide novel inspiration in firing up the tumor microenvironment. In this review, we presented progress and limitations of conventional immunotherapies. Then, we enumerate advantages of nanoparticle-based therapies in remodeling the “cold” tumor microenvironment. Finally, we discuss the prospect of nanoparticle-based therapies in clinical application.

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Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer

Cited by 73 publications

References 38 publications

Immunogenic Cell Death Induction by Ionizing Radiation

Immunogenic Cell Death Induction by Ionizing Radiation

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies

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