Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos

Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice

“…To the best of our knowledge, only three experimental studies have revealed weight gain after early-life (Lassiter and Brimijoin, 2008) or adulthood exposures to CPF (Ehrich et al, 2004;Meggs and Brewer, 2007). The present investigation indicated that repeated exposure to CPF induced a weight gain in both apoE3 and C57BL/ 6N mice.…”

“…It has been classified as a potent inhibitor of both systemic and brain cholinesterases (ChE), leading to the onset of acute neurotoxic symptomatology. However, an increasing body of reports have suggested that CPF also disrupts the serotonergic neurotransmitter system (Slotkin et al, 2015), targets serine hydrolase enzymes (Quistad et al, 2006b) and interferes with the signaling of hormones, some of which -for example, insulin and leptin-are related to energy homeostasis (Lassiter and Brimijoin, 2008;Slotkin et al, 2005). In accordance, sundry investigations have shown that CPF exposure induce a broad spectrum of effects, including metabolic disturbances (Lasram et al, 2014;Peris-Sampedro et al, 2014).…”

“…Nevertheless, experimental studies are scarce. Very little research has investigated the metabolic and endocrine effects that emerge following adulthood exposure to CPF in rodents, being most studies focused on early-life exposure (Lassiter and Brimijoin, 2008;Slotkin et al, 2005). Current knowledge of adulthood exposure to CPF is limited to four studies carried out in rats.…”

Effects of a single high dose of Chlorpyrifos in long-term feeding, ethanol consumption and ethanol preference in male Wistar rats with a previous history of continued ethanol drinking

“…The fact that CPF triggered augmented feeding with no changes in BW is consistent with recent experimental evidence showing that neonatal organophosphate exposure causes long-lasting effects on metabolism that might contribute to the development of obesity and diabetes (Lassiter and Brimijoin, 2008;Meyer et al, 2004;Slotkin et al, 2005). In the same direction, chronic exposure to the OP chlorpyrifos (CPF) in adult rats increased body weight gain (Meggs and Brewer, 2007); additionally, CPF triggered a biphasic response in neonates, with enhanced BW gain at low doses, whereas the effect was lost at higher doses (Lassiter and Brimijoin, 2008). Furthermore, neonatal CPF exposure altered the programming of metabolic function (Meyer et al, 2004) and exposure of neonatal rats to parathion elicited sex-selective and dose-dependent metabolic disturbances .…”

Toxicant Exposures and the Obesity Epidemic

“…While studying the effects of exposure to the organophosphorus insecticide chlorpyrifos on memory in rats at a dose that did not produce symptoms of acute cholinesterase inhibition, we reported in this journal that rats exposed to chlorpyrifos had increased adipose tissue relative to controls [3]. Development exposure to chlorpyrifos has also been demonstrated to induce weight gain [4]. Chlorpyrifos and related compounds were extensively used for indoor pest control in American homes, schools, and offices until the United States Environmental Protection Agency phased out this route of exposure beginning in 2000 [5].…”