RDM1 gene overexpression represents a therapeutic target in papillary thyroid carcinoma

Li, Wei; Huang, Qing; Sun, Dongdong; Zhang, Guizhi; Tan, Jian

doi:10.1530/ec-17-0209

Cited by 9 publications

(15 citation statements)

References 20 publications

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“…Previous work showed the regulation of RDM1 in lung cancer [16] and papillary thyroid carcinoma [17]. However, in this study, we identified RDM1 as an oncogenic target in NB.…”

Section: Discussioncontrasting

confidence: 62%

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RDM1 promotes neuroblastoma growth through the RAS–Raf–MEK–ERK pathway

Xie

Cai

et al. 2019

FEBS Open Bio

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Neuroblastoma ( NB ) is an aggressive cancer that originates in the sympathetic nervous system and primarily affects children. Here, we show that high levels of RAD 52 motif containing 1 ( RDM 1; a protein with similarities to RAD 52, which is important for double‐strand DNA repair) are associated with poor clinical outcomes for NB . In addition, RDM 1 −/− cells exhibited increased sensitivity to cisplatin, a common chemotherapy drug, and disruption of RDM 1 suppressed NB cell proliferation. We also report that loss of RDM 1 augmented cell apoptosis and induced cell cycle arrest, and that stable knockdown of RDM 1 significantly inhibited NB tumor growth in a xenograft mouse model. Importantly, we identified that RDM 1 promoted cell proliferation via the RAS –Raf–mitogen‐activated protein kinase kinase ( MEK )–extracellular signal‐regulated kinase ( ERK ) signaling pathway. In conclusion, the current study demonstrates a correlation between DNA damage regulator RDM 1 and the oncogenic RAS –Raf– MEK – ERK pathway in NB .

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“…Previous work showed the regulation of RDM1 in lung cancer [16] and papillary thyroid carcinoma [17]. However, in this study, we identified RDM1 as an oncogenic target in NB.…”

Section: Discussioncontrasting

confidence: 62%

“…The repair of double‐strand breaks (DSBs) is mediated by RAD52‐dependent recombination and the genomic integrity resulted from dysfunctional DNA damage response (DDR) signaling in the DNA repair pathways . RDM1 was found to have function in lung cancer and papillary thyroid carcinoma , but its function in NB progression remains unclear.…”

mentioning

confidence: 99%

RDM1 promotes neuroblastoma growth through the RAS–Raf–MEK–ERK pathway

Xie

Cai

et al. 2019

FEBS Open Bio

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“…Recent work has revealed high levels of RDM1 in papillary thyroid carcinoma 11 . But expression of RDM1 in lung cancer remains to be explored.…”

Section: Resultsmentioning

confidence: 99%

“…Yet its function in cancer-related pathways is seldom explored. A recent work was shown that high RDM1 level was found in papillary thyroid carcinoma 11 . But the role of RDM1 in human lung adenocarcinoma remains unknown.…”

Section: Discussionmentioning

confidence: 97%

RDM1 plays an oncogenic role in human lung adenocarcinoma cells

Liu

Yan

et al. 2018

Sci Rep

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RAD52 motif containing 1 (RDM1) is involved in DNA damage repair pathway and RDM1−/− cells increase sensitivity to cisplatin, a common chemotherapy drug. Lung cancer is the leading cause of cancer death worldwide. However, the role of RDM1 in lung cancer is unknown. Here, we find that the mRNA and protein expression levels of RDM1 are significantly increased in human lung tumors, especially in lung adenocarcinoma. The lung adenocarcinoma patients with higher mRNA expression of RDM1 show the worse clinical outcomes. Knockdown of RDM1 in lung adenocarcinoma cells reduces cell proliferation and promotes apoptosis, consistent with the role RDM1 in the overexpression experiments. Xenograft mouse model shows stable knockdown of RDM1 significantly inhibits lung adenocarcinoma tumor growth. These in vitro and in vivo results conclude that RDM1 plays an oncogenic role in human lung adenocarcinoma. Interestingly, P53/RAD51/RAD52 can be regulated by RDM1, and the negative regulation of P53 by RDM1 may be one of major mechanisms for RDM1 to accomplish its oncogenic functions in lung adenocarcinoma. Therefore, RDM1 may be a new target for the treatment of lung adenocarcinoma.

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“…Recently, some new works have revealed that RDM1 has high expression level in papillary thyroid carcinoma and lung adenocarcinoma [11][12][13]. However, the expression of RDM1 in ovarian cancer remains to be explored.…”

Section: Rdm1 Is Up-regulated In Human Ovarian Carcinoma Tumoursmentioning

confidence: 99%

RDM1 plays an oncogenic role in human ovarian carcinoma cells

Cao

Sheng³

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Ovarian cancer is one of the deadliest gynecological cancer, with a low overall 5-year survival rate. RDM1, RAD52 motif-containing protein 1, is sensitive to cisplatin, a common chemotherapy drug and it has an important role inDNA damage repair pathway. Until now, the effect of RDM1 in ovarian cancer is undiscovered. Here, clinical data shows that the tumour tissues of ovarian carcinoma patients with higher mRNA and protein expression of RDM1. Knockdown of RDM1 in ovarian carcinoma cells reduces cell proliferation and promotes apoptosis, consistent with the role RDM1 in the overexpression experiments. The research of xenograft mouse model shows stable knockdown of RDM1 significantly inhibits ovarian cancer tumour growth. These in vitro and in vivo results conclude that RDM1 plays an oncogenic role in human ovarian carcinoma. Interestingly, p53/RAD51/RAD52 signalling pathway can be regulated by RDM1, and the negative regulation of p53 by RDM1 may be one of major mechanisms for RDM1 to accomplish its oncogenic functions in ovarian carcinoma. Therefore, RDM1 may be a new target for the treatment of ovarian carcinoma.

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RDM1 gene overexpression represents a therapeutic target in papillary thyroid carcinoma

Cited by 9 publications

References 20 publications

RDM1 promotes neuroblastoma growth through the RAS–Raf–MEK–ERK pathway

RDM1 promotes neuroblastoma growth through the RAS–Raf–MEK–ERK pathway

RDM1 plays an oncogenic role in human lung adenocarcinoma cells

RDM1 plays an oncogenic role in human ovarian carcinoma cells

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