Re-evaluation of histidyl-proline diketopiperazine [cyclo(his-pro)] effects on food intake in the rat

Bowden, Charles R.; Karkanias, Chris D.; Bean, Andrew J.

doi:10.1016/0091-3057(88)90169-4

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…Morley et al , (1981) were the first to demonstrate that intracerebral administration of CHP to rats led to suppression of food intake induced by stress, fasting, or spontaneous feeding [ 142 ]. While many investigators [ 143 , 144 , 145 ] have supported this initial observation, Bowden et al , (1988) could not demonstrate any anorectic role for CHP [ 146 ]. An anorectic or satiety-modulating role for CHP is supported by elevation of CHP in brains of hyperphagic obese Zucker rats [ 147 ] and fasted Sprague–Dawley rats [ 148 ] and changes in plasma CHP in patients (anorexia nervosa and bulimia) with satiety disturbances [ 149 ].…”

Section: Select Examples Of Bioactive Plant Metabolites With Potenmentioning

confidence: 98%

Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

et al. 2015

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There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to stem the rise. Furthermore, a large segment of the world population cannot afford expensive pharmacotherapy. Therefore, there is an urgent need for inexpensive preventive measures to control the rise in CVD and diabetes and associated co-morbidities. The purpose of this review is to explore the role of food bioactives in prevention of NCDs. To this end, we have critically analyzed the possible utility of three classes of food bioactives: (a) resistant starch, a metabolically resistant carbohydrate known to favorably modulate insulin secretion and glucose metabolism; (b) cyclo (His-Pro), a food-derived cyclic dipeptides; and (c) polyphenol-rich berries. Finally, we have also briefly outlined the strategies needed to prepare these food-bioactives for human use.

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Section: Select Examples Of Bioactive Plant Metabolites With Potenmentioning

confidence: 98%

Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

et al. 2015

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“…Since food-intake is usually modified in obesity [11], knowledge of the mechanisms involved in TRH could lead to novel treatments for this condition. Although some reviews have included the effect of TRH on food-intake [12][13][14][15][16][17][18][19], the understanding of its mechanisms of action is far from consensus. In this manuscript, we review the original literature on the role of TRH in foodintake, focusing mainly on functional and anatomical studies, excluding studies that do not precisely indicate the circuit under analysis, and most studies describing correlative evidence; it is a perspective, based on recent advances in the circuits that control food-intake, TRH cell and receptors' cartographies, and functional effects of TRH in multiple anatomical sites, that addresses hypotheses about TRH circuits that are involved in food-intake control.…”

Section: Introductionmentioning

confidence: 99%

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Vargas,

Castro Tron,

Charli

et al. 2024

Preprint

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Thyrotropin releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food-intake is not well understood. We review data that show that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence suggests that TRH neurons that are prime candidate vectors for TRH action on food-intake include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food-intake control in each anatomical scene.

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“…Since food intake is usually modified in obesity [ 11 ], knowledge of the mechanisms involved in TRH could lead to novel treatments for this condition. Although some reviews have included the effect of TRH on food intake [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ], the understanding of its mechanisms of action is far from consensus. In this manuscript, we review the original literature on the role of TRH in food intake.…”

Section: Introductionmentioning

confidence: 99%

“…The following supporting information [ 13 , 69 , 95 , 98 , 164 , 168 , 177 , 191 , 192 , 193 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 ] can be downloaded at: , Table S1: Overview of studies regarding the effect of peripheral administration of TRH, TRH analog, and TRH catabolite on food intake behavior in mammals; Table S2: Overview of studies regarding the effect of administration of TSH or thyroid hormones on food intake behavior in mammals; Table S3: Overview of studies regarding the effect of central administration of TRH, its immediate precursor, a catabolite, an analog, an antisense oligonucleotide, or anti-TRH on food intake behavior in mammals.…”

mentioning

confidence: 99%

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

Vargas,

Castro Tron,

Rodríguez Rodríguez

et al. 2024

Metabolites

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Thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake is not well understood. We review studies demonstrating that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence points to TRH neurons that are prime candidate vectors for TRH action on food intake. These include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food intake control in each anatomical scene.

show abstract

Re-evaluation of histidyl-proline diketopiperazine [cyclo(his-pro)] effects on food intake in the rat

Cited by 15 publications

References 25 publications

Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

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