Re: <i>Helicobacter pylori</i> infection and gastric cancer: Facing the enigmas

Tokudome, Shinkan; Kuriki, Kiyonori; Suzuki, Sadao; Akasaka, Susumu; Kosaka, Hiroshi; Ishikawa, Hideki; Yoshimura, Takesumi; Azuma, Takeshi; Van, Do Duc; Khan, Nguyen Cong; Sriamporn, Supannee; Wiangnon, Surapon; Soeripto,; Triningsih, FX Ediati; Moore, Malcolm A

doi:10.1002/ijc.20392

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Bacterial infections (79)(80)(81), viral infections (82-84), fungal contamination (85,86), parasitic infections (87) as well as physical agents (for example, asbestos and small air particulates) (88)(89)(90) have been linked to inflammation effecting the tumor-promotion phase of carcinogenesis rather than the initiation phase.…”

Section: Inflammation Tumor Promotion and Antioxidants As Chemoprevmentioning

confidence: 99%

Dietary Modulation of the Multistage, Multimechanisms of Human Carcinogenesis: Effects on Initiated Stem Cells and Cell–Cell Communication

Trosko¹

2006

Nutrition and Cancer

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Diet can influence the risk to cancer in both negative and positive ways. Worldwide, more than 10 million persons develop cancer annually. Diet could prevent many cancers. Carcinogenesis is a multistage, multimechanism process, consisting of "initiation," "promotion," and "progression" phases. Although diet could affect each phase, an efficacious strategy for dietary chemoprevention would be intervention during the promotion phase. The tumor-promotion process requires sustained exposure to agents that stimulate the growth and inhibition of apoptosis of initiated cells in the absence of antipromoters. Chronic inflammation has been associated with the promotion process. The mechanism affecting the promotion process appears to be the inhibition of cell-cell communication between normal and initiated cells. Most, if not all, tumor-promoting agents and conditions, reversibly, inhibit cell-cell communication, whereas antipromoters, antioxidants, and anti-inflammatory agents have been shown to ameliorate the effects of tumor promoters on cell-cell communication. Additionally, adult stem cells are hypothesized to be the target cells for initiating the carcinogenic process. A new paradigm has been presented that postulates the first function of the carcinogenic process is to block the "mortalization" of a normal, "immortal" adult stem cell rather than the induction of "immortalization" of a normal mortal cell.

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Section: Inflammation Tumor Promotion and Antioxidants As Chemoprevmentioning

confidence: 99%

Dietary Modulation of the Multistage, Multimechanisms of Human Carcinogenesis: Effects on Initiated Stem Cells and Cell–Cell Communication

Trosko¹

2006

Nutrition and Cancer

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“…Some population-based studies showed that high levels of H. pylori infection were not accompanied by high gastric cancer mortality, the so-called African (6)(7)(8) and Asian enigmas (9). The wide variation in the risk of gastric cancer mortality in Chile, with a relatively homogeneous population, would permit us to assess the ecological association of gastric cancer and H. pylori.…”

Section: Introductionmentioning

confidence: 99%

Gastric Cancer is Related to Early Helicobacter pylori Infection in a High-Prevalence Country

Ferreccio

Rollán

Harris

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background and Aims: Chile ranks fifth in the world among countries with the highest incidence of gastric cancer. The aim was to quantify the association between Helicobacter pylori infection and gastric cancer mortality at the county of residence. Methods: A cross-sectional household survey, a probability sample of the Chilean adult population, provided 2,615 participants in whom serum H. pylori IgG antibodies were measured (ELISA). The spatial pattern of 48,367 deaths due to gastric cancer which occurred from 1985 to 2002 was analyzed using a hierarchical Poisson regression model; 333 counties were categorized as low, medium, and high gastric cancer mortality with median gastric cancer death rates of 11.4, 19.1, and 26.0 per 100,000 inhabitants, respectively. The association between H. pylori positivity and gastric cancer mortality in the county of residence was assessed by multivariate Poisson regression for complex samples.

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Diet/Nutrition, Inflammation, Cellular Senescence, Stem Cells, Diseases of Aging, and Aging

Trosko¹,

Tai²,

Sopczynski³

et al. 2014

Inflammation, Advancing Age and Nutrition

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Re: Helicobacter pylori infection and gastric cancer: Facing the enigmas

Cited by 5 publications

References 10 publications

Dietary Modulation of the Multistage, Multimechanisms of Human Carcinogenesis: Effects on Initiated Stem Cells and Cell–Cell Communication

Dietary Modulation of the Multistage, Multimechanisms of Human Carcinogenesis: Effects on Initiated Stem Cells and Cell–Cell Communication

Gastric Cancer is Related to Early Helicobacter pylori Infection in a High-Prevalence Country

Diet/Nutrition, Inflammation, Cellular Senescence, Stem Cells, Diseases of Aging, and Aging

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