Re-implantation and Homotransplantation of the Lung

Hardy, James D.; Eraslan, Şadan; Dalton, Martin L.; Alican, F; Turner, M. Don

doi:10.1097/00000658-196305000-00005

Cited by 77 publications

(8 citation statements)

References 5 publications

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“…Despite all the improvements in transplantation technique, thrombosis of the venous anastomosis is still the most serious complication (Alican and Hardy, 1963;Hardy, Eraslan, and Webb, 1964;Borrie and Lichter, 1964;Davies et al, 1965). Even immaculate venous anastomosis may suffer thrombosis.…”

Section: Discussionmentioning

confidence: 99%

“…Many authors (Blumenstock et al, 1962;Alican and Hardy, 1963;Bulcherl et al, 1964a, b;Hardy et al, 1964) have suggested that denervation may cause a reduction in the function of the transplant. Of three possible ways in which such a reduction could take place-namely, impairment of ventilation, perfusion, or diffusion-we wish to exclude impairment of perfusion.…”

Section: Discussionmentioning

confidence: 99%

“…Blumenstock, Collins, Hechtman, Thomas, and Ferrebee (1962) and later de Bono and Brock (1964) observed long-term survival after the administration of methotrexate. Hardy, Eraslan, Dalton, Alican, and Turner (1963a) achieved good results with azathioprine (Imuran). The immunopressive action of this drug has also been proved by its successful use after the transplantation of human kidneys.…”

mentioning

confidence: 99%

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Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

T¹,

Trenkner²

1966

Thorax

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

T¹,

Trenkner²

1966

Thorax

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“…The increasing success of experimental cardiac transplantation led Hardy and his colleagues, at the University of Mississippi Medical Centre, to consider heart transplantation in man. This group had considerable experience in the field of animal studies, both of cardiac transplantation (Webb andHoward, 1957a, 1957b;Webb et al, 1959Webb et al, , 1961Lee andWebb, 1958, 1959;Hardy et al, 1964a;Kurrus et al, 1964) and of lung transplantation (Hardy et al, 1963a(Hardy et al, , 1963bAlican and Hardy, 1963), and had carried out lung homotransplantation in man on one occasion (Hardy et al, 1963c).…”

Section: Cardiac Transplantation In Man-first Attemptmentioning

confidence: 99%

Experimental development of cardiac transplantation.

Cooper¹

1968

BMJ

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“…To this end, technical refinements as well as immunosuppressive studies in canine models of pulmonary auto- or allotransplantation have paved the way for the first successful human lung transplants (1-3). Introduction of cuff techniques has allowed for the widespread use of orthotopic lung transplantation in the rat (4).…”

Section: Introductionmentioning

confidence: 99%

Orthotopic vascularized right lung transplantation in the mouse

Sugimoto

Lai

et al. 2010

The Journal of Thoracic and Cardiovascular Surgery

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Objectives Orthotopic left lung transplantation in the mouse, recently developed by our laboratory, represents a physiological model for studies in transplantation biology. However, due to the limited overall respiratory contribution of the murine left lung, left lung transplant recipients remain healthy despite immune-mediated graft necrosis. We sought to develop a lung transplant model where animal survival depends on graft function. Methods Orthotopic vascularized right lung transplants utilizing cuff techniques were performed in syngeneic and allogeneic strain combinations. Grafts were assessed histologically or functionally by measuring arterial blood gases from 7 to 28 days after transplantation. In a parallel set of experiments syngeneic and immunosuppressed allogeneic hosts underwent a left pneumonectomy two weeks following right lung transplantation with assessment of graft function one week later. Results We performed 40 right lung transplantations with a survival rate of 87.5%. Syngeneic grafts remain free of inflammation as far as 28 days after transplantation. On day 7, arterial oxygen levels in syngeneic recipients (481 ± 90 mmHg) are equivalent to those in naïve mice (503 ± 59 mmHg) following left hilar occlusion. Alternatively, allogeneic grafts develop histological evidence of acute rejection and arterial oxygen levels are significantly lower after left hilar clamping (53.3 ± 10.3 mmHg). Syngeneic as well as immunosuppressed allogeneic right lung recipients tolerate a left pneumonectomy. Conclusions Right lung transplantation followed by left pneumonectomy represents the first survival model of vascularized lung transplantation in the mouse and will therefore allow for the design of novel studies in experimental lung transplantation.

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Re-implantation and Homotransplantation of the Lung

Cited by 77 publications

References 5 publications

Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.

Experimental development of cardiac transplantation.

Orthotopic vascularized right lung transplantation in the mouse

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