Re: “Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood”

Major, Tanya J; Krishnan, Mohanraj; Topless, Ruth; Dewes, Ofa; Thompson, John M. D.; Zoysa, Janak de; Stamp, Lisa K.; Dalbeth, Nicola; Deka, Ranjan; Weeks, Daniel E.; Minster, Ryan L.; Wilcox, Phillip; Grattan, David R.; Shepherd, Peter R.; Shelling, Andrew N.; Murphy, Rinki; Merriman, Tony R.

doi:10.1038/s41366-018-0025-1

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…A similar association between rs373863828 and height was observed in a cohort of M aori and Pacific adults from New Zealand (β = 1.25 cm; p = 3.90 × 10 −6 ) (Metcalfe et al, 2020). Additionally, association between rs373863828 and early childhood growth between ages 2 and 4 years old has been previously reported in a separate cohort including self-identified M aori and Pacific from New Zealand (Berry et al, 2018a;Berry et al, 2018b;Major et al, 2018).…”

Section: Discussionsupporting

confidence: 78%

A missense variant in CREBRF is associated with taller stature in Samoans

Carlson

Rosenthal

Russell

et al. 2020

American J Hum Biol

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Objectives: Studies have demonstrated that rs373863828, a missense variant in CREBRF, is associated with a number of anthropometric traits including body mass index (BMI), obesity, percent body fat, hip circumference, and abdominal circumference. Given the biological relationship between height and adiposity, we hypothesized that the effect of this variant on BMI might be due in part to an association of this variant with height. Methods: We tested the hypothesis that minor allele of rs373863828 is associated with height in a Samoan population in two adult cohorts and in a separate cohort of children (age 5-18 years old) using linear mixed modeling. Results: We found evidence of a strong relationship between rs373863828 and greater mean height in Samoan adults (0.77 cm greater average height for each copy of the minor allele) with the same direction of effect in Samoan children. Conclusions: These results suggest that the missense variant rs373863828 in CREBRF, first identified through an association with larger BMI, may be related to an underlying biological mechanism affecting overall body size including stature.

show abstract

Section: Discussionsupporting

confidence: 78%

A missense variant in CREBRF is associated with taller stature in Samoans

Carlson

Rosenthal

Russell

et al. 2020

American J Hum Biol

Self Cite

View full text Add to dashboard Cite

show abstract

“…A similar association between rs373863828 and height was observed in a cohort of Māori and Pacific adults from New Zealand (β = 1.25 cm; p = 3.90 × 10 −6 ) (T. R. Merriman, personal communication, April 15, 2019). Additionally, association between rs373863828 and early childhood growth between ages 2 and 4 years old has been previously reported in a separate cohort including self-identified Māori and Pacific from New Zealand (Berry et al, 2018b, 2018a; Major et al, 2018).…”

Section: Discussionmentioning

confidence: 69%

A missense variant in CREBRF is associated with taller stature in Samoans

Carlson

Rosenthal

Russell

et al. 2019

Preprint

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ObjectivesStudies have demonstrated that rs373863828, a missense mutation in CREBRF, is associated with a number of anthropometric traits including body mass index (BMI), obesity, percent body fat, hip circumference, and abdominal circumference. Given the biological relationship between height and adiposity, we hypothesized that the effect of this variant on BMI might be due in part to a previously untested association of this variant with height.MethodsWe tested the hypothesis that minor allele of rs373863828 is associated with height in a Samoan population in two adult cohorts and in a separate cohort of children (age 5 - 18 years old) using linear mixed modeling.ResultsWe found evidence of a strong relationship between rs373863828 and greater mean height in Samoan adults (0.77 cm greater average height for each copy of the minor allele) with the same direction of effect in Samoan children.ConclusionsThese results suggest that the missense variant rs373863828 in CREBRF, first identified through an association with larger BMI, may be related to an underlying biological mechanism affecting overall body size including stature.

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Re: “Widespread prevalence of a CREBRF variant amongst Māori and Pacific children is associated with weight and height in early childhood”

Berry

Walker

et al. 2018

Int J Obes

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Re: “Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood”

Cited by 5 publications

References 8 publications

A missense variant in CREBRF is associated with taller stature in Samoans

A missense variant in CREBRF is associated with taller stature in Samoans

A missense variant in CREBRF is associated with taller stature in Samoans

Re: “Widespread prevalence of a CREBRF variant amongst Māori and Pacific children is associated with weight and height in early childhood”

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