Re: Wood GD, Inion biodegradable plates: The first century. Br J Oral Maxillofac Surg 2006;44:38–41

We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials.

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Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants

Scotchford

Shataheri

Chen

et al. 2010

J Biomedical Materials Res

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INION® compared with titanium osteosynthesis: a prospective investigation of the treatment of mandibular fractures

Leonhardt

Demmrich

Mueller

et al. 2008

British Journal of Oral and Maxillofacial Surgery

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Fixation of zygomatic and mandibular fractures with biodegradable plates

Degala

Shetty

Ramya

2013

Ann Maxillofac Surg

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Context:In this prospective study, 13 randomly selected patients underwent treatment for zygomatic–complex fractures (2 site fractures) and mandibular fractures using 1.5 / 2 / 2.5-mm INION CPS biodegradable plates and screws.Aims:To assess the fixation of zygomatic-complex and mandibular fractures with biodegradable copolymer osteosynthesis system.Materials and Methods:In randomly selected 13 patients, zygomatic-complex and mandibular fractures were plated using resorbable plates and screws using Champy's principle. All the cases were evaluated clinically and radiologically for the type of fracture, need for the intermaxillary fixation (IMF) and its duration, duration of surgery, fixation at operation, state of reduction at operation, state of bone union after operation, anatomic reduction, paresthesia, occlusal discrepancies, soft tissue infection, immediate and late inflammatory reactions related to biodegradation process, and any need for the removal of the plates.Statistical Analysis Used:Descriptives, Frequencies, and Chi-square test were used.Results:In our study, the age group range was 5 to 55 years. Road traffic accidents accounted for the majority of patients six, (46.2%). Postoperative occlusal discrepancies were found in seven patients as mild to moderate, which resolved with IMF for 1-8 weeks. There were minimal complications seen and only as soft tissue infection.Conclusions:Use of biodegradable osteosynthesis system is a reliable alternative method for the fixation of zygomatic-complex and mandibular fractures. The biodegradable system still needs to be refined in material quality and handling to match the stability achieved with metal system. Biodegradable plates and screws is an ideal system for pediatric fractures with favorable outcome.

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Re: Wood GD, Inion biodegradable plates: The first century. Br J Oral Maxillofac Surg 2006;44:38–41

Cited by 4 publications

References 1 publication

Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants

Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants

INION® compared with titanium osteosynthesis: a prospective investigation of the treatment of mandibular fractures

Fixation of zygomatic and mandibular fractures with biodegradable plates

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