We examine the spectrum of superparticles obtained from the minimal SO(10) grand unified model, where it is assumed the gauge symmetry breaking yields the Minimal Supersymmetric Standard Model (MSSM) as the effective theory at M GU T ∼ 2 × 10 16 GeV. In this model, unification of Yukawa couplings implies a value of tan β ∼ 45 − 55. At such high values of tan β, assuming universality of scalar masses, the usual mechanism of radiative electroweak symmetry breaking breaks down. We show that a set of weak scale sparticle masses consistent with radiative electroweak symmetry breaking can be generated by imposing non-universal GUT scale scalar masses consistent with universality within SO(10) plus extra D-term contributions associated with the reduction in rank of the gauge symmetry group when SO(10) spontaneously breaks to SU (3)×SU (2)×U (1). We comment upon the consequences of the sparticle mass spectrum for collider searches for supersymmetry. One implication of SO(10) unification is that the light bottom squark can be by far the lightest of the squarks. This motivates a dedicated search for bottom squark pair production at pp and e + e − colliders.PACS numbers: 14.80. Ly, 13.85.Qk, 11.30.Pb Typeset using REVT E X 1 Unification of the Standard Model (SM) of strong, weak and electromagnetic interactions within a single Lie group such as SU(5) or SO(10) has a long history and many attractive features [1]. SU(5) is the smallest grand unifying group, and predicts the quantization of electric charge, the unification of gauge couplings and the unification of bottom and tau Yukawa couplings at scales of Q = M GU T ≃ 10 15 GeV [2]. The SO(10) theory incorporates all the matter fields of the SM into the 16-dimensional spinor representation, ψ 16 , of SO(10) [3]. In minimal SO(10), not only the gauge couplings but all the Yukawa couplings (within a generation) are unified at Q = M GU T . If the right-handed neutrino field present in ψ 16 acquires a large Majorana mass, it decouples from the theory, and a small neutrino mass is induced via the see-saw mechanism [4].The supersymmetric version of this model, with supersymmetry (SUSY) softly broken at a scale < ∼ 1 TeV naturally stabilizes the hierarchy between the weak scale and the grandunification scale. Supersymmetry also raises the unification scale to M GU T ≃ 2 × 10 16 GeV, which helps reduce the rate for proton decay to below the level of experimental bounds. In addition, the introduction of supersymmetry with soft SUSY breaking (SSB) masses of order the weak scale allows for the near unification of gauge coupling constants [5]. In supergravity-based models, it is usually assumed that all scalar masses receive a common, while all gauginos receive a common mass m 1/2 and all trilinear SSB terms unify to A 0 . The SSB masses and couplings are then evolved via renormalization group equations (RGEs) fromHu term is driven to negative values, which results in radiative breaking of electroweak symmetry, provided the top quark mass is large (e.g. 175 GeV).In addition...