Reaching Activity in the Medial Posterior Parietal Cortex of Monkeys Is Modulated by Visual Feedback

Bosco, Annalisa; Breveglieri, Rossella; Chinellato, Eris; Galletti, Claudio; Fattori, Patrizia

doi:10.1523/jneurosci.2313-10.2010

Cited by 52 publications

(56 citation statements)

References 45 publications

(65 reference statements)

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“…All of these data support the view that V6A uses visual information for the on-line control of goal-directed hand actions Bosco et al, 2010). Present findings are consistent with the hypothesis that visual mechanisms mediating the control of skilled actions directed to target objects are functionally and neurally distinct from those mediating the perception of objects (Goodale et al, 1994).…”

supporting

confidence: 89%

Vision for Action in the Macaque Medial Posterior Parietal Cortex

Fattori

Breveglieri²,

Raos³

et al. 2012

J. Neurosci.

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Area V6A encodes hand configurations for grasping objects (Fattori et al., 2010). The aim of the present study was to investigate whether V6A cells also encode three-dimensional objects, and the relationship between object encoding and grip encoding. Single neurons were recorded in V6A of two monkeys trained to perform two tasks. In the first task, the monkeys were required to passively view an object without performing any action on it. In the second task, the monkeys viewed an object at the beginning of each trial and then they needed to grasp that object in darkness. Five different objects were used. Both tasks revealed that object presentation activates ϳ60% of V6A neurons, with about half of them displaying object selectivity. In the Reach-to-Grasp task, the majority of V6A cells discharged during both object presentation and grip execution, displaying selectivity for either the object or the grip, or in some cases for both object and grip. Although the incidence of neurons encoding grips was twofold that of neurons encoding objects, object selectivity in single cells was as strong as grip selectivity, indicating that V6A cells were able to discriminate both the different objects and the different grips required to grasp them.Hierarchical cluster analysis revealed that clustering of the object-selective responses depended on the task requirements (view only or view to grasp) and followed a visual or a visuomotor rule, respectively. Object encoding in V6A reflects representations for action, useful for motor control in reach-to-grasp.

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supporting

confidence: 89%

Vision for Action in the Macaque Medial Posterior Parietal Cortex

Fattori

Breveglieri²,

Raos³

et al. 2012

J. Neurosci.

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“…Recorded cells were assigned to V6Av or V6Ad on the basis of the cytoarchitectural pattern of recording sites (Luppino et al, 2005). The functional properties of many neurons have been described in our previous studies (Galletti et al, 1996(Galletti et al, , 1999aFattori et al, 2001Fattori et al, , 2005Fattori et al, , 2009Fattori et al, , 2010Breveglieri et al, 2002;Bosco et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

“…A detailed description of the methodologies used to study reaching activity is reported in recent works by Fattori and coworkers Bosco et al, 2010).…”

Section: Motor-related Activitymentioning

confidence: 99%

Is the Medial Posterior Parietal Area V6A a Single Functional Area?

Gamberini

Galletti²,

Bosco³

et al. 2011

J. Neurosci.

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The visuomotor medial posterior parietal area V6A has been recently subdivided into two cytoarchitectonic sectors called V6Ad and V6Av (Luppino et al., 2005). The aim of the present study was to recognize whether these two cortical sectors show different functional profiles. Fourteen hemispheres from eight animals (Macaca fascicularis) were included in this study, for a total of 3828 extracellularly recorded neurons assigned to areas V6Ad or V6Av on cytoarchitectural basis. The sensitivity of recorded neurons to sensory-and motor-related activities was checked with a series of functional tests performed on behaving animals. We found that cells sensitive to visual stimuli were more represented in V6Av and cells sensitive to somatosensory stimuli were more represented in V6Ad. Visual cells directly encoding spatial locations (real-position cells) were present only in V6Av. Cells encoding basic visual and somatic properties as well as different aspects of reaching and grasping activities were present in both sectors of V6A, although with different incidence. Cells that had reach-related activity enhanced by visual feedback and grasping neurons activated by whole-hand prehension were more concentrated in V6Av. Conversely, reaching neurons inhibited by visual feedback and grasping neurons activated by precision grip were more represented in V6Ad. Although V6Av and V6Ad show partly different functional profiles, our data support the idea that V6A is a single functional area involved in the control of reach-to-grasp movements, with the dorsal sector (V6Ad) more involved in the somatomotor control and the ventral sector (V6Av) in the visual control of reaching and grasping actions.

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“…V6A is strongly connected with PPC areas that encode eye movements and fixations in depth, like the lateral intraparietal area (LIP) and area 7a (Gamberini et al, 2009;Passarelli et al, 2011). It also contains neurons modulated by arm-reaching movements in 3D space Marzocchi et al, 2008;Bosco et al, 2010), and by gaze position in a frontoparallel plane (Galletti et al, 1995;Nakamura et al, 1999).…”

Section: Introductionmentioning

confidence: 99%