Reaction-bonded bioresorbable composite material

Lukina, Yu. S.; Sventskaya, N. V.; Golikova, P. V.; Sivkov, S. P.; Beletskii, B. I.; Зайцев, В. В.

doi:10.1007/s10717-013-9541-6

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Brushite cement possesses porosity (≈40-45%), pH (≈3.3) and compressive strength (15 MPa), thereby 90brushite/10Bioglass composites demonstrated slightly enhanced pH and compressive strength up to ≈ 3.8 and 16 MPa, respectively, as well as a bimodal pore structure on holding in buffer solution [117]. Bioglass incorporation always enhances the pH as bioglass content increases, especially in composites containing crystallized glass granules compared to amorphous glass granules, but decreases the rate of brushite crystallization [113]. It was established that the optimal incorporated bioglass content should be not greater than 10 wt.%, irrespective of the form of the initial β-TCP and the type of glass (amorphous or crystalline), as such composites possess desirable properties [113]: strength in compression 12-20 MPa, pH 4.2-5.5, and high resorption rate 8-20%.…”

Section: Immersionmentioning

confidence: 98%

“…The advantages of CPCs include high biocompatibility and bioactivity, nontoxicity, an abundant source of calcium and phosphate ions, and the ability to easily hand-moulding of blocks with complex shapes. The disadvantages of CPCs include being hardly suited for critical bone defects, the lack of bone tissue integration to accelerate new bone formation, low mechanical properties and pH, the absence of macro-pores (only intrinsic nano-pores), and sometimes very high setting time [89,[112][113][114].…”

Section: Immersionmentioning

confidence: 99%

“…In fact, Lukina et al [113,117] investigated bioglass-powder-incorporating brushite cement composites (100 − x)brushite/xBioglass (x = 0, 10, 20 wt.%), where the composition of bioglass was close to that of Bioglass 45S5, i.e., 25 Na 2 O, 20 CaO, 50 SiO 2 , and 5 P 2 O 5 wt.%. Brushite was obtained by Reaction (1).…”

Section: Immersionmentioning

confidence: 99%

“…Bioglass incorporation always enhances the pH as bioglass content increases, especially in composites containing crystallized glass granules compared to amorphous glass granules, but decreases the rate of brushite crystallization [113]. It was established that the optimal incorporated bioglass content should be not greater than 10 wt.%, irrespective of the form of the initial β-TCP and the type of glass (amorphous or crystalline), as such composites possess desirable properties [113]: strength in compression 12-20 MPa, pH 4.2-5.5, and high resorption rate 8-20%. The biocompatibility and bioactivity of these composites have been confirmed in vitro and in vivo [113,117].…”

Section: Immersionmentioning

confidence: 99%

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Materials in the Na2O–CaO–SiO2–P2O5 System for Medical Applications

Kaimonov,

Safronova

2023

Materials

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Calcium phosphate materials and materials based on silicon dioxide have been actively studied for more than 50 years due to their high biocompatibility and bioactivity. Hydroxyapatite and tricalcium phosphate are the most known among calcium phosphate materials, and Bioglass 45S5 is the most known material in the Na2O–CaO–SiO2–P2O5 system. Each of these materials has its application limits; however, some of them can be eliminated by obtaining composites based on calcium phosphate and bioglass. In this article, we provide an overview of the role of silicon and its compounds, including Bioglass 45S5, consider calcium phosphate materials, talk about the limits of each material, demonstrate the potential of the composites based on them, and show the other ways of obtaining composite ceramics in the Na2O–CaO–SiO2–P2O5 system.

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Section: Immersionmentioning

confidence: 98%

Section: Immersionmentioning

confidence: 99%

Section: Immersionmentioning

confidence: 99%

Section: Immersionmentioning

confidence: 99%

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Materials in the Na2O–CaO–SiO2–P2O5 System for Medical Applications

Kaimonov,

Safronova

2023

Materials

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“…Plasticizing additives, pore formers, and reinforcing fibers and additives for regulating setting times are introduced into cement mixes. The optimal content of the main component (calcium phosphate) and different kinds of additives ensures that the required level of the physical-mechanical properties, pore structure, machinability, and manufacturability is attained in the articles [5].…”

mentioning

confidence: 99%

Development of Biomaterials Based on Calcium Phosphates: Information Support for Research

et al. 2015

Self Cite

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An information system containing reference information on the physical, chemical, and biological properties of calcium orthophosphates, pyrophosphates, and ultraphosphates is described. Aside from reference information the system contains a file of publications from different domestic and foreign search systems on the presented classes of calcium phosphates as well as on implantation materials based on them. The user and search interfaces of the system, intended for specialists in the field of inorganic materials and medical materials science, are described.The rapid advancement of medical materials science is explained by the need to develop high-efficiency, safe, and biocompatible artificial implantation materials (biomaterials) and medical devices capable of increasing the regenerative potential of the human body and restoring the wholeness and functionality of different organs and tissues. Implantation materials make it possible to replace the transplantation materials (materials of natural origin) in current use and thereby solve the problem of the immune conflict, histo-compatibility, and infection of the recipient organism from the donor organism. Research aimed at developing and manufacturing implantation materials and articles based on calcium phosphates for osteoplastic surgery, orthopedics, traumatology, and stomatology is a significant segment in the present market for science-intensive technologies.Biomaterials are called artificial implantation materials, functioning in contact and in interaction with live tissues and organs. Biomaterials must possess biocompatibility and in terms of the response of the surrounding tissues on the material can be bioinert, bioactive, and biodegradable [1].Biocompatibility is a property of biomaterials enabling the organism to respond adequately to implantation. Biocompatible materials are nontoxic and do not generate adverse organism-side immune other reactions [2]. Among biocompatible materials bioactive materials capable of initiating restorative processes in the implantation zone are singled out; a large class is represented by calcium phosphates.At present the following basic types of calcium-phosphate bioactive implantation materials for osteoplastics differing by the production technology and physical-mechanical properties are singled out [3 -5]:1) calcium-phosphate ceramic; 2) calcium-phosphate glass and glass ceramic; 3) calcium-phosphate cements; 4) composites based on calcium phosphates + polymers and calcium phosphates + metals.Different calcium-phosphate compounds which are responsible for biological activity and biological compatibility comprise the mineralogical base of the material (to 98 -99 wt.%) in the production of the indicated bioactive implantation materials and articles. Aside from calcium phosphates different sintering additives, flux additives, reinforcing substances, and pore formers are present in the initial mix of the components in ceramic and glassy implantation materials [3,4]. Plasticizing additives, pore formers, and reinforcing

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