Reaction of ozone with sulfhydryls of human erythrocytes

Freeman, Bob A.; Mudd, J.B.

doi:10.1016/0003-9861(81)90142-9

Cited by 85 publications

(30 citation statements)

References 45 publications

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“…Uric acid and ascorbic acid were found to be the major plasma scavengers of 03 (81). Although it is often assumed that lipids are a major target of attack by 03, no evidence of substantial lipid damage by 03 was obtained (81), in keeping with other studies in the literature (82,83). Instead, oxidative protein damage was observed in 03-exposed plasma, as -SH group loss and protein carbonyl formation (84).…”

Section: Causes Of Oxidative Stress: Environmental Air Pollutantssupporting

confidence: 73%

Oxygen-derived species: their relation to human disease and environmental stress.

Halliwell

Cross

1994

Environ Health Perspect

490

276

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Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body, often for useful metabolic purposes. Antioxidant defenses protect against them, but these defenses are not completely adequate, and systems that repair damage by ROS are also necessary. Mild oxidative stress often induces antioxidant defense enzymes, but severe stress can cause oxidative damage to lipids, proteins, and DNA within cells, leading to such events as DNA strand breakage and disruption of calcium ion metabolism. Oxidative stress can result from exposure to toxic agents, and by the process of tissue injury itself. Ozone, oxides of nitrogen, and cigarette smoke can cause oxidative damage; but the molecular targets that they damage may not be the same. -Environ Health Perspect 1 02(Suppl 1 0): 5-12 (1994)

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Section: Causes Of Oxidative Stress: Environmental Air Pollutantssupporting

confidence: 73%

Oxygen-derived species: their relation to human disease and environmental stress.

Halliwell

Cross

1994

Environ Health Perspect

490

276

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“…It can form free radicals and other reactive intermediates by oxidizing the biological molecules. It can cause lipid peroxidation [44] and oxidize different functional groups, for example, amine, alcohol, aldehyde and sulphydryl, present in proteins [45,46] and nucleic acids [47]. It can also cause chromosomal aberrations which may be due to direct attack by O 3 or by the free radicals generated by it [48].…”

Section: Reactive Oxygen Species (Ros) and Reactive Nitrogen Species mentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

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“…The pollutant directly, or through highly reactive free radical mediated reactions, oxidizes the amino acidic residues, mainly of tyrosine, tryptophan, cysteine, methionine and histidine (Mudd et al 1969). In particular, it reacts with the exposed sulphydryl groups to form disulphides bridges, and with tryptophan to give protein ozonides, in turn generating protein hydroperoxides and hydrogen peroxide (Freeman and Mudd 1981). Tyrosine residues can be cross-linked too, after the oxidation of their −OH groups, to give O,O'-dityrosine (Ignatenko et al 1984).…”

Section: Ros Productionmentioning

confidence: 99%

Oxidative Stress, the Paradigm of Ozone Toxicity in Plants and Animals

Iriti

Faoro

2007

Water Air Soil Pollut

134

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Tropospheric ozone represents a relevant atmospheric pollutant, because of its strong oxidizing potential. The risk for animal (human) and plant health, at molecular and cellular level, arises from the oxidative damage to lipids, proteins and nucleic acids, depending on the dose. Therefore, ozone concentration and exposure time determine the chronic or acute toxicity and, consequently, the severity of injury at biochemical and physiological level. In living organisms, reactive oxygen species (ROS), directly or indirectly derived from ozone exposure, are scavenged by enzymatic and non-enzymatic antioxidant defensive mechanisms, overall deputed to preserve cell structures and biomacromolecules from the oxidative damage. These defences are essentially those also involved in detoxifying the ROS inevitably produced by the metabolism of organisms living in oxygenic atmosphere.

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Reaction of ozone with sulfhydryls of human erythrocytes

Cited by 85 publications

References 45 publications

Oxygen-derived species: their relation to human disease and environmental stress.

Oxygen-derived species: their relation to human disease and environmental stress.

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Oxidative Stress, the Paradigm of Ozone Toxicity in Plants and Animals

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