Reaction of Sodium Amoxicillin with Cu(II) Ion in a Methanolic Medium

Navarro, Pilar; Parras, P. J. Martinez De Las; García, A. Márquez

doi:10.1002/jps.2600800921

Cited by 16 publications

(5 citation statements)

References 11 publications

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“…This metal‐catalyzed hydrolysis seems to have complex chemistry, involving the catalyzed effect of the metal ion as well as complex formation. So far, various analytical methods including spectrophotometry, fluorimetric, pH‐potentiometry and electrospray ionization mass spectrometry (ESI‐MS), have been used for studying the interaction of AMX with copper (II) ions, only in one study this interaction was studied by electrochemical method …”

Section: Introductionsupporting

confidence: 85%

Chronoamperometric Detection of Amoxicillin at Graphite Electrode using Chelate Effect of Copper(II) Ions : Application in Human Blood and Pharmaceutical Tablets

et al. 2019

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A novel electrochemical method is suggested for indirect chronoamperometric determination of amoxicillin (AMX) in the presence of copper ions Cu (II) at carbon paste electrode (CPE). The method is based on the interaction between the β-lactam antibiotic and copper ions. This interaction was firstly studied by square wave voltammetry (SWV), where the peak corresponding to the oxidation of AMX at 0.7 V decreases significantly in the presence of copper ions. The reaction product is characterized by UV-visible spectrophotometry and Infrared spectroscopy (IR). Moreover, when AMX was added to supporting electrolyte containing copper ions, the chronoamperomet-ric current of the Cu(II)/Cu(I) redox system was increased. Hence, this increase in the current was used for indirect determination of amoxicillin. By selecting an appropriate concentration of copper (II), the calibration curve for AMX was established in the concentration range of 1.95 × 10 À 7 to 1.46 × 10 À 5 mol L À 1 . The detection limit was found to be 8.84 × 10 À 8 mol L À 1 . The influence of different organic compounds on the AMX determination and the effect of coexisting of other metal ions in the electrolytic solution were studied. The applicability of the proposed method was tested in human blood and pharmaceutical tablets.

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Section: Introductionsupporting

confidence: 85%

Chronoamperometric Detection of Amoxicillin at Graphite Electrode using Chelate Effect of Copper(II) Ions : Application in Human Blood and Pharmaceutical Tablets

et al. 2019

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“…These methods included spectrophotometry [15][16][17][18][19][20][21][22][23][24], high performance liquid chromatography [2,9,[25][26][27][28][29], capillary eletrophoresis [30], fluorimetry [31][32][33][34][35], polarography [36][37][38][39][40] and titrimetry [41].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy<SUP>#</SUP>

Moreno¹,

Salgado²

2012

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Ceftazidime quantification by the infrared spectroscopy was developed and validated for pharmaceutical preparations in powder for injection. This method involved absorbance measurements of the band corresponding to aromatic ring centered by 1475-1600 cm-1. Selectivity, linearity, precision and accuracy were determined in order to validate the proposed method. It was also found that the excipient did not interfere with the assay. Calibration curve was obtained for ceftazidime at 0.5 to 7.0 mg, and mean recovery percentage was 98.98 ± 0.70. The proposed method was successfully applied to the assay of ceftazidime in powder for injection.

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“…Substances potentially acidic can function as acids only in the presence of a base to which they can donate a Titrimetric Methods for the Determination of Ceftazidime in Pharmaceutical Formulations proton. Conversely basic properties do not become apparent unless an acid also is present [18,19].…”

Section: Nonaqueous Methodsmentioning

confidence: 99%

“…For Several analytical procedures are available in the literature for the analysis of cephalosporins. These methods are spectrophotometry [18][19][20][21][22][23][24][25][26][27], high performance liquid chromatography [28][29][30][31][32], capillary electrophoresis [33], fluorimetry [34][35][36][37][38], polarography [39][40][41][42][43] and titrimetry [44].…”

Section: Introductionmentioning

confidence: 99%

Comparison of High Performance Liquid Chromatography and Three Titrimetric Methods for the Determination of Ceftazidime in Pharmaceutical Formulations

Moreno¹,

Salgado²

2012

AAC

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Three different assays for the quality control of ceftazidime in commercial formulations were developed and compared: acidimetric, iodometric and nonaqueous methods. Method validation yielding good results and included precision and accuracy, with good recovery percent ranged from 99.67 to 100.39, and R.S.D. values smaller than 2%. Results were compared to those obtained by high performance liquid chromatographic method, developed and published previously by us, and no evidence of significant difference was observed. The results obtained agreed well with the contents stated on the labels, being rapid, simple and inexpensive alternative method for the determination of ceftazidime in pharmaceutical formulations.

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Reaction of Sodium Amoxicillin with Cu(II) Ion in a Methanolic Medium

Cited by 16 publications

References 11 publications

Chronoamperometric Detection of Amoxicillin at Graphite Electrode using Chelate Effect of Copper(II) Ions : Application in Human Blood and Pharmaceutical Tablets

Chronoamperometric Detection of Amoxicillin at Graphite Electrode using Chelate Effect of Copper(II) Ions : Application in Human Blood and Pharmaceutical Tablets

Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy<SUP>#</SUP>

Comparison of High Performance Liquid Chromatography and Three Titrimetric Methods for the Determination of Ceftazidime in Pharmaceutical Formulations

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