Reaction of sound and demineralised dentine to Carisolv in vivo and in vitro

Dammaschke, Till; Stratmann, U.; Mokrys, Kai; Kaup, Magdalena; Ott, K.

doi:10.1016/s0300-5712(01)00060-4

Cited by 27 publications

(21 citation statements)

References 16 publications

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“…The 'new' Carisolv with its 100 per cent higher NaOCl concentration might cause increased damage to pulp tissue. However, previous research has shown that the original Carisolv caused no, or only minor, deviations to pulp tissue compared to control groups after direct [4][5][6] or indirect 7 contact. Although the effects on pulp tissue in direct contact with the original Carisolv did not differ from the controls, [4][5][6] it is still necessary to examine possible reactions of pulp tissue in direct contact with Carisolv 'new gel' in order to exclude local toxic effects.…”

Section: Introductionmentioning

confidence: 80%

“…It is well known that Carisolv does not react with healthy hard tissue in teeth. 7 It can be suggested that Carisolv might be more reactive on exposed pulp tissue in noncarious teeth than in carious teeth because all chemical agents are focused to attack the pulp tissue and will not be consumed and subsequently neutralized by carious dentine. The extension of pulp tissue destruction is limited by the penetration ability of its two radicals (i.e., OCl -and OH -), which are liberated by dissociation of sodium hypochlorite in body fluids.…”

Section: Discussionmentioning

confidence: 99%

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Reaction of rat pulp tissue to Carisolv ‘new gel’—‐A histocytological evaluation

Dammaschke

Stratmann

Danesh

et al. 2006

Australian Dental Journal

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Background: This study was an histological examination of pulp tissue exposed to Carisolv 'new gel' after 1 to 28 days. Methods: An occlusal cavity was prepared in 64 caries-free molar teeth of 16 Wistar rats. The roofs of the pulp chambers were perforated and Carisolv 'new gel' solution was placed onto the exposed pulps of 32 molar teeth for 20 minutes. Thirty-two contralateral molar teeth served as controls and were coated with an inert liquid containing isotonic saline solution and carmellose for 20 minutes as well. The pulps of all teeth were capped with Ca(OH) 2 and the cavities were filled with a flowable composite in combination with a self-etching dentine adhesive. The animals were sacrificed after 1, 3, 7 and 28 days. Eight teeth per group and the time period were histologically examined, scored, and statistically evaluated (Wilcoxon-test). Results:The results showed no statistically significant differences between the Carisolv group and the control group (p>0.05). The observed pulp reaction was essentially the same as those reported in the past being typical for the effect of calcium hydroxide as a direct pulp capping agent. Conclusion: Compared to Ca(OH) 2 , Carisolv 'new gel' did not cause any different or additional pulp reaction in healthy teeth.Key words: Carisolv, 'new gel', rat, pulp, tissue reaction.Abbreviations and acronyms: EDTA = ethylenediaminetetraacetic acid; LM = light microscopical; NaOC1 = sodium hypochlorite; RAPMB = Resulcin AquaPrime + MonoBond; TEM = transmission electron microscopical.

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Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Reaction of rat pulp tissue to Carisolv ‘new gel’—‐A histocytological evaluation

Dammaschke

Stratmann

Danesh

et al. 2006

Australian Dental Journal

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“…Since molar teeth of rats are used to evaluate the effect of materials on the dental pulp (18)(19)(20)(21), knowledge of dental pulp metabolism is very important. However, surprisingly, we did not find this matter in the literature.…”

Section: Discussionmentioning

confidence: 99%

Lactate dehydrogenase isoenzymes in dental pulp of rats according to stage of root development

Losso

Nicolau

2003

Braz. Dent. J.

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The objective of this study was to present a classification of the root development stage of female rat molar teeth and to evaluate the variation in the lactate dehydrogenase (LDH) activity and electrophoretic isoenzyme profile according to the stage of root development of the molar teeth. We also studied the LDH activity and isoenzymes of the pulp of incisor teeth. The stage of development of the rat first molar at the age of 15 days and that of the second molar at the age of 18 days was classified as the beginning of root formation. At the age of 15 days, the electrophoretic profile of the isoenzymes for the first molar showed a prevalence of LDH-1 followed by LDH-2. However, for the maxillary second molar there was a prevalence of LDH-4 followed by LDH-1, while for the mandibular second molar LDH-1 predominated followed by LDH-2 and LDH-4. From 18 days of age, the prevalence was always of LDH-1. The electrophoretic profile of LDH isoenzymes from the pulp of the incisor teeth at the ages studied (25 and 60 days) showed the following order of prevalence: LDH-1 > LDH-2 > LDH-3 > LDH-4 > LDH-5. These results suggest that there are variations in the prevalence of the various forms of LDH isoenzymes in the dental pulp of rats according to the developmental stage of the root.

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“…Young and Bongenhielm 12 reported a safety profile for Carisolv on pulp tissue, but other studies on pulp tissue reactions revealed that radicals of Carisolv (OH 2 and OCI 2 ) caused alkaline hydrolysis of cellular components. 13,22 There is only one published study concerning the soft tissue reactions after direct contact with Carisolv. 23 In the study by Arvidsson et al, 23 it was shown that Carisolv can be considered as a harmless solution.…”

Section: Discussionmentioning

confidence: 99%