Reaction of trivalent phosphorus compounds with α,β-unsaturated ketones

Efficient Approaches for the Synthesis of Substituted Thiazolo[3,2‐a]‐benzimidazole‐Phosphonates and ‐Phosphinic Diamide Derivatives

“…Finaly, the new synthesized phosphorus compounds, are noteworthy for their potential biological activity, especially because they are associated with various heterocycles Particularly remarkable is α ‐hydroxyphosphonates, which are considered structural analogs of α‐hydroxyphosphonic acids , . In turn, they can serve as enzyme inhibitors for purine nucleoside phosphorylase, human rennin, farnesyl protein transferase (FPT), and other …”

High Resolution Nuclear Magnetic Resonance Investigation of the Structure of the Adducts Formed by the Interaction of Benzylidenemalononitriles with Trialkylphosphines

“…The shifts are close to the value found for the closely related compound 9, known to contain positively charged phosphorous, namely -31 p.p.m. (8).…”

“…they too analyze as 1 :1 adducts. There is indirect evidence in support of structure 2 in that the structures of closely related species formed by the action of trivalent phosphorous compounds on cr,P unsaturated ketones (8,9) have been recently established as being zwitterion~.~ Because of their direct relevance to the postulated mechanism of nucleophilic substitution reactions of alkenes, an attempt has been made in the present work to define absolutely the structure of these adducts, with a view to ultimately determining the kinetic parameters for their formation and decomposition and the dependence of both these parameters on substituents and on solvents.…”

N-Persulfonylierte Aminophosphane und Diaminophosphane

“…Using SO 3 as an oxidant, the phosphane oxides Ph n Cl 2-n P(O)N(SO 2 Me) 2 (n = 0, 1, 2) could be produced from the corresponding aminophosphanes. For all the compounds, 31 P and 1 H NMR spectra are reported, Et 2 PN(SO 2 Me) 2 (3 b) displaying a remarkably large 1 H shift non-equivalence of the diastereotopic CH 2 protons (Dd = 0.62 ppm). Whereas single crystals suitable for X-ray diffraction could not be grown for any of the diaminophosphanes, low-temperature X-ray analyses were conducted for Cl 2 PN(SO 2 Me) 2 (1 a; monoclinic, space group P2 1 /c, Z = 8, two independent molecules), Me(Cl)PN(SO 2 Me) 2 (2 a; monoclinic, P2 1 /n, Z = 4) and 3 b (monoclinic, P2 1 /c, Z = 4).…”

“…Bei Vorversuchen mit 31 Die Verbindungen 6±8 sind farblose hydrolyseempfindliche Feststoffe, die scharf schmelzen (6 unter Zersetzung). Wie bei den Stammphosphanen bewirkt auch hier der Ersatz eines Chlorliganden am P-Atom durch N(SO 2 Me) 2 eine Hochfeldverschiebung der 31 P-Absorption (Tab.…”