Reactions of Bis(thiosemicarbazonato) Copper(II) complexes with tumor cells and mitochondria

Chan-Stier, Christine; Minkel, Daniel T.; Petering, David H.

doi:10.1016/s0006-3061(00)80227-6

Cited by 46 publications

(14 citation statements)

References 13 publications

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“…Nonetheless, many questions still remain open about what could occur to copper thiosemicarbazones in the complex intracellular environment: it is unclear if these compounds retain their structural integrity inside cell or if the metal ion is released from the ligand, after the reduction from Cu(II) to Cu(I) [23,25]. An increase of copper concentration inside cells results in general poisoning, inhibition of DNA synthesis and oxidative phosphorylation as well as widespread oxidation of thiols to disulfides [26].…”

Section: Discussionmentioning

confidence: 99%

Copper(II) thiosemicarbazonate molecular modifications modulate apoptotic and oxidative effects on U937 cell line

Bisceglie

Pinelli

Alinovi

et al. 2012

Journal of Inorganic Biochemistry

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Section: Discussionmentioning

confidence: 99%

Copper(II) thiosemicarbazonate molecular modifications modulate apoptotic and oxidative effects on U937 cell line

Bisceglie

Pinelli

Alinovi

et al. 2012

Journal of Inorganic Biochemistry

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“…They possess strong antineoplastic activity against a number of transplantable tumors, spontaneous murine tumors and human tumors. The mechanism of their antitumor action is thought to involve either inhibition of the enzyme ribonucleotide reductase, an obligatory enzyme in DNA synthesis [5][6][7], or creation of lesions in DNA strands [8]. The antifungal activity of Ni(II), Cu(II) and Zn(II) complexes with 5-nitro-2-furfural thiosemicarbazone has been demonstrated [9,10].…”

Section: Introductionmentioning

confidence: 99%

Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity

Roșu

Gulea²,

Nicolae

et al. 2007

Molecules

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Abstract:The chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-Rtricyclo [7.3.1.0. 2,7 ]tridecane-13-one (where R = H, CH 3 , C 6 H 5 ) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways -neutral bidentate or mononegative bidentate -depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand. The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.

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“…The proposed method in current work consisted of making potentiometric measurments of hydrogen ion concentration solution of AMB in the presence and absence of the studied metal ions [30]. The titration was performed in the presence of 0.1 M sodium nitrate.…”

Section: Potentiometric Titrationsmentioning

confidence: 99%

Complexation equilibria of ambroxol hydrochloride in solution by potentiometric and conductometric methods

et al. 2018

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The formation constants of Li(I), Mg(II), Sr(II), Ca(II), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Ba(II), Pb(II), Al(III), Cr(III), Fe(III) and Th(IV) ions with ambroxol hydrochloride (AMB) were calculated using the half-n value. In presence of 0.1 M NaNO3, metal ions such as Zn(II), Cd(II), Ni(II), Cr(III), Li(I), Mg(II) and Al(III) forms three types of metal-ligand complexes (1:1, 1:2 and/or 1:3), while Sr(II) and Co(II) tend to form two types of metal complexes 1:1 and 1:2 (M:L). For ligand protonation constants, two logarithmic association constant values were calculated by the half-n method and are 10.7 and 7.6, respectively. The effect of ionic strength on stability constant of AMP, with different metal ions viz. Fe(III), Th(IV), Al(III), Cr(III) and Cu(II) was studied. Based on relationship between the ionic strength studied values and the 1st stability constants (Log K1H), we can conclude that the stability constants of the formed metal-ligand complex (1:1) were decreased as the ionic strength increased. The stoichiometry of the formed complexes in solution were determined by conductometric method and it is found to be of 1:1, 1:2 and/or 1:3 (M:L) complex species is formed in alkaline media. Also, study the species distribution diagrams of AMP for the calculated mole fraction αML and αML2 were discussed.

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Reactions of Bis(thiosemicarbazonato) Copper(II) complexes with tumor cells and mitochondria

Cited by 46 publications

References 13 publications

Copper(II) thiosemicarbazonate molecular modifications modulate apoptotic and oxidative effects on U937 cell line

Copper(II) thiosemicarbazonate molecular modifications modulate apoptotic and oxidative effects on U937 cell line

Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity

Complexation equilibria of ambroxol hydrochloride in solution by potentiometric and conductometric methods

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