Reactions of inorganic free radicals with liver protecting drugs

György, I.; Blázovics, Anna; Fehér, János; Földiák, G.

doi:10.1016/1359-0197(90)90234-9

“…[35][36][37][38] Furthermore, the phenolic conformation of silymarin is thought to permit the formation of stable compounds from hydroxylic and oxygen radicals. 39,40 Primary defenses against oxidation or free radical production include glutathione, catalase, and superoxide dismutase. In the setting of an acute toxic event, if stores of these compounds are depleted in intracellular or extracellular (sinusoidal) compartments, oxidative injury is unimpeded.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Reasons for the Ways of Using Oilcakes in Food Industry

Bochkarev¹,

Yu.²,

Yu.³

et al. 2016

FRM

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The Agency for Healthcare Research and Quality (AHRQ), formerly the Agency for Health Care Policy and Research, through its Evidence-based Practice Centers (EPCs), sponsors the development of evidence reports and technology assessments to assist public and private-sector organizations in their efforts to improve the quality of health care in the United States. The reports and assessments provide organizations with comprehensive, science-based information on common, costly medical conditions and new health care technologies. The EPCs systematically review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses when appropriate prior to developing their reports and assessments. To bring the broadest range of experts into the development of evidence reports and health technology assessments, AHRQ encourages the EPCs to form partnerships and enter into collaborations with other medical and research organizations. The EPCs work with these partner organizations to ensure that the evidence reports and technology assessments they produce will become building blocks for health care quality improvement projects throughout the Nation. The reports undergo peer review prior to their release. AHRQ expects that the EPC evidence reports and technology assessments will inform individual health plans, providers, and purchasers as well as the health care system as a whole by providing important information to help improve health care quality. We welcome written comments on this evidence report.

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“…We are adapting and developing state-of-the-art, accurate assays for in vitro and in vivo herbal extracts, herbal medicines and dietary supplements. Over the years, we have used spectrophotometric, luminometric, HPLC, GC, GC/MS, HPLC-DAD-MS/MS, OPTLC, ESR, impulse radiolysis and ICP-OES techniques to answer our questions [1][2][3][4][5][6][7][8][9][10][11][12][13]. Direct and indirect methods were used to determine the antioxidant and scavenger properties of bioactive molecules.…”

Section: Medical Biochemical Research At Hungary (Semmelweis University)mentioning

confidence: 99%

Regulation of Herbal Medicine in Hungary

Hegyi

¹

,

Blázovics

²

2020

CEI

1

0

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In order to meet the growing needs of the European Union medicinal and aromatic plants, Hungary is still one of the major exporters today, although earlier, until the 1980s, we were considered a great herb-growing nation. Therefore, the development of the national medicinal and aromatic herb growing sector is an essential requirement for maintaining and developing our market position. The natural conditions of Hungary favor the cultivation of medicinal and aromatic plants. There are more than 330 herbs in our country. About seventy percent of the drugs grown and harvested are exported. However, significant changes are needed in domestic sales and further processing in order to become a leading industrial sector. Hungary also possesses modern separation techniques and large instruments for analysis, which allow the proper analytical examination of drugs and the precise determination of their active substances. Our universities and research institutes are also prepared to study the active ingredients of herbs by molecular biological methods, which may allow the exact mechanism of action of bioactive substances to be determined and the herbs to be reassessed. Our accession to the European Union the palette of products made from former herbs has significantly changed. From 2013, the category of medicinal product was discontinued, and the preparations were classified as either food or medicine. However, there are significant costs associated with qualifying as a drug, so drugs or extracts are largely added to dietary supplements. As a result, the strange situation is that dietary supplements are prohibited from making any health claims, even though the dietary supplement is actually not for the benefit of a healthy population, but for those who have a health problem or do not have suitable foods, which are rich in bioactive substances. The justification of phytotherapy must be demonstrated, depending on the state of the art. In the context of safe therapy, studies must follow the requirements of medicines and only then can they become herbal medicines. There is still much to be desired in this area in our country. Classification as a drug is based on expensive animal tests and clinical studies. A new problem arises here, as herbal cure is currently part of the arsenal of complementary medicine. With few exceptions, clinical doctors do not use herbal therapies. Patients usually ask the advice of pharmacists, naturalists, and more rarely, dietitians. At the Arteriosclerosis Research Group, at the II. Department of Medicine and Institute of Pharmacognosy several decades of biomedical research have served and serve the purpose of evaluating and reassessing the effects of plants used in folk medicine. Over the years, we have been searching for drugs, extracts, and medicines of natural origin that are useful in liver and intestinal diseases known in folk medicine, and are believed to have lipid lowering, antioxidant and immune stimulating effects. In the article, animal and human studies will be also presented.

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“…Over the years, we have used spectrophotometric, luminometric, HPLC, GC, GC/MS, HPLC-DAD-MS/MS, OPTLC, ESR, impulse radiolysis and ICP-OES techniques to answer our questions. [1][2][3][4][5][6][7][8][9][10][11][12][13] Direct and indirect methods were used to determine the antioxidant and scavenger properties of bioactive molecules. Spectrophotometric and luminometric methods were developed to investigate the antioxidant property in vitro and in vivo.…”

Section: Medical Biochemical Research At Hungary (Semmelweis University)mentioning

confidence: 99%

Regulation of herbal medicine in Hungary

Hegyi¹,

Blázovics²

2020

IJCAM

0

View full text Add to dashboard Cite

In order to meet the growing needs of the European Union medicinal and aromatic plants, Hungary is still one of the major exporters today, although earlier, until the 1980s, we were considered a great herb-growing nation. Therefore, the development of the national medicinal and aromatic herb growing sector is an essential requirement for maintaining and developing our market position.The natural conditions of Hungary favor the cultivation of medicinal and aromatic plants. There are more than 330 herbs in our country. Of the cultivated herbs, chamomile, mint and lavender are of paramount importance.The largest areas are mustard, poppy, fennel and coriander, as well as St. John's wort and lemongrass. Many herbs are grown farming on large-scale methods, such as cumin, anise or mustard. Marjoram or marigold can be grown in smaller areas with greater manual labor. About seventy percent of the drugs grown and harvested are exported. The major buyers are Spain and Germany. However, significant changes are needed in domestic sales and further processing in order to become a leading industrial sector. Hungary also possesses modern separation techniques and large instruments for analysis, which allow the proper analytical examination of drugs and the precise determination of their active substances. Our universities

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Reactions of inorganic free radicals with liver protecting drugs

Cited by 7 publications

References 7 publications

Reasons for the Ways of Using Oilcakes in Food Industry

Reasons for the Ways of Using Oilcakes in Food Industry

Regulation of Herbal Medicine in Hungary

Regulation of herbal medicine in Hungary

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