Reactions of phthalaldehyde with ammonia and amines

Nouvelle voie de synthèse d'isoindolones et d'isoquinoléines par condensation d'iminophosphoranes avec l'ortho-phtalaldéhyde: réactions, mécanismes et étude structurale

“…L'attribution des signaux singulets correspondants aux mtthylknes intra-et extracycliques des isoindolones lc-f a t t t Concernant la strie des isoindolones 2 , seul le compost 2a (R = Ph) a t t t dtcrit par DoMinh et al (21). Celui-ci n'a cependant foumi aucune preuve formelle pour confirmer la structure proposte et en particulier Climiner une structure de type isoquinoltine.…”

Crystal structure of 2-tert-butyl-2,3-dihydro-1H-benzo[c]pyrrol-1-one

“…The reactions of OPA with primary amines, which were carried out by Winter (1900) and Thiele & Schneider (1909) for the first time, have been broadly applied for the synthesis of important heterocyclic compounds with biological relevance. A number of such reactions have been investigated recently and several structures of condensation products have been reported (DoMinh et al, 1977;Nan'ya et al, 1985;Takahashi et al, 1996Takahashi et al, , 2004Takahashi et al, , 2005Takahashi & Hatanaka, 1997). However, the reaction mechanism is still not fully understood.…”

“…1. The reaction of OPA with aliphatic primary amines represents a concurrent process (DoMinh et al, 1977). All attempts to isolate and identify the products of the reaction of OPA with primary amines in aqueous solutions were unsuccessful due to the number of reactions occurring and products, including the oligo-and polymeric ones (checked by thin-layer chromatography).…”

“…Analogous to the reaction of OPA with isopropylamine (Donkeng Dazie, Liška, Ludvík, Fá bry & Dušek, 2016), the first step of the reaction with tert-butylamine results in a primary carbinolamine, (IV), the intermediate which further yields the title product, (V) (DoMinh et al, 1977). The title product, (V), as well as co-product (VI), namely (3R*,1 0 S*,3 The reaction scheme for the synthesis of the title compound, (V).…”

Derivati izoindolina, sinteza i biološka aktivnost. I. Prirodni i sintetski derivati izoindolina

“…Na temelju tog otkrića razvile su se polarografske metode za dokazivanje amonijaka, a kasnije i za detekciju pora znojnica u koži. 12 No tek se 70-ih godina počeo detaljnije proučavati takav tip reakcija. U novije vrijeme razvijene su metode višekomponentnih reakcija koje u jednom stupnju (eng.…”