Reactions of protonated water clusters H+(H2O)n (n=1–6) with dimethylsulfoxide in a guided ion beam apparatus

Kawai, Yoko; Yamaguchi, Satoru; Okada, Yohji; Takeuchi, Kazuo; Yamauchi, Yusuke; Ozawa, Shoichi; Nakai, Hiromi

doi:10.1016/s0009-2614(03)01095-9

Cited by 42 publications

(47 citation statements)

References 16 publications

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“…The proton affinity of a water cluster increases with size (n = 1, 696 kJ/mol; n = 2, 833 kJ/ mol; n = 3, 889 kJ/mol; n = 4, 920 kJ/mol; etc.) [28]. Proton affinity values of molecules similar to those studied range from 857-1055 kJ/mol (Online Resource 1).…”

Section: Resultsmentioning

confidence: 94%

Humidity Effects on Fragmentation in Plasma-Based Ambient Ionization Sources

Newsome

Ackerman

Johnson³

2015

J. Am. Soc. Mass Spectrom.

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Abstract. Post-plasma ambient desorption/ionization (ADI) sources are fundamentally dependent on surrounding water vapor to produce protonated analyte ions. There are two reports of humidity effects on ADI spectra. However, it is unclear whether humidity will affect all ADI sources and analytes, and by what mechanism humidity affects spectra. Flowing atmospheric pressure afterglow (FAPA) ionization and direct analysis in real time (DART) mass spectra of various surface-deposited and gas-phase analytes were acquired at ambient temperature and pressure across a range of observed humidity values. A controlled humidity enclosure around the ion source and mass spectrometer inlet was used to create programmed humidity and temperatures. The relative abundance and fragmentation of molecular adduct ions for several compounds consistently varied with changing ambient humidity and also were controlled with the humidity enclosure. For several compounds, increasing humidity decreased protonated molecule and other molecular adduct ion fragmentation in both FAPA and DART spectra. For others, humidity increased fragment ion ratios. The effects of humidity on molecular adduct ion fragmentation were caused by changes in the relative abundances of different reagent protonated water clusters and, thus, a change in the average difference in proton affinity between an analyte and the population of water clusters. Control of humidity in ambient post-plasma ion sources is needed to create spectral stability and reproducibility.

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Section: Resultsmentioning

confidence: 94%

Humidity Effects on Fragmentation in Plasma-Based Ambient Ionization Sources

Newsome

Ackerman

Johnson³

2015

J. Am. Soc. Mass Spectrom.

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“…However, we found that the s r at nῌ2 was approximately twice as large as that of H ῌ (H 2 O) 4 in the reaction with dimethylsulfoxide (DMSO), whereas such enhancement of s r at n ῌ2 was not observed in the reaction with acetone 15) nor with D 2 O. It was suggested that the s r was enhanced at nῌ2 because of the larger proton a$nity, PA, of DMSO than that of the water dimer.…”

Section: Introductionmentioning

confidence: 81%

Reactions of Protonated Water Clusters H+(H2O)n (n=2 and 4) with D20, Acetonitrile, Acetone, DMS, DMSO, and Pyridine

Kawai

Yamaguchi

Okada

et al. 2004

J. Mass Spectrom. Soc. Jpn.

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“…It is known that as protonated water clusters increase in size, so too does the proton affinity (PA) of the cluster [22][23][24]. The calculated PAs of the observed clusters, n = 2, 3, and 4 are 832, 888, and 919 kJ·mol -1 , respectively [23].…”

Section: Schlieren Experimental Setupmentioning

confidence: 99%

Characterization of a Direct Sample Analysis (DSA) Ambient Ionization Source

Winter

Wilhide

LaCourse

2015

J. Am. Soc. Mass Spectrom.

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Abstract. Water cluster ion intensity and distribution is affected by source conditions in direct sample analysis (DSA) ionization. Parameters investigated in this paper include source nozzle diameter, gas flow rate, and source positions relative to the mass spectrometer inlet. Schlieren photography was used to image the gas flow profile exiting the nozzle. Smaller nozzle diameters and higher flow rates produced clusters of the type [H + (H 2 O) n ] + with greater n and higher intensity than larger nozzles and lower gas flow rates. At high gas flow rates, the gas flow profile widened compared with the original nozzle diameter. At lower flow rates, the amount of expansion was reduced, which suggests that lowering the flow rate may allow for improvements in sampling spatial resolution.

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Reactions of protonated water clusters H+(H2O)n (n=1–6) with dimethylsulfoxide in a guided ion beam apparatus

Cited by 42 publications

References 16 publications

Humidity Effects on Fragmentation in Plasma-Based Ambient Ionization Sources

Humidity Effects on Fragmentation in Plasma-Based Ambient Ionization Sources

Reactions of Protonated Water Clusters H+(H2O)n (n=2 and 4) with D20, Acetonitrile, Acetone, DMS, DMSO, and Pyridine

Characterization of a Direct Sample Analysis (DSA) Ambient Ionization Source

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