Reactions to Althesin

Severe Histamine Mediated Reactions to Intravenous Drugs Used in Anaesthesia

“…However, in a number of these the diagnosis is equivocal. Avery and Evans (1973) described five cases. In Cases 2 and 3 no attempt is made to exclude either suxamethonium or alcuronium respectively as the causative agent and Case 4 describes a nervous asthmatic in an acute state whose asthma became worse after althesin; no other histamine mediated reaction manifestations occurring.…”

Primary Neuropathic Amyloidosis in Three Brothers

“…When reviewing these reports it becomes clear that asthma is a frequent feature in these patients. In some instances premedication (Avery and Evans, 1973) or the use of other drugs may have been involved and recent reports suggest that similar reactions may occur to muscle relaxants (Jerums et al, 1967;Hainsworth and Bingham, 1970).…”

Anaphylactic and Anaphylactoid Reactions

“…The effects produced have included restlessness during injection, hypotension, bronchospasm and mottling of the skin at the site of the injection (Horton, 1973;Mehta, 1973;Kessell and Assem, 1974;Tweedie and Ordish, 1974). In addition, hypersensitivity reactions have been described in which patients, although reacting normally to an initial dose of Althesin, reacted adversely to a subsequent dose given 11 days to 1 month later (Avery and Evans, 1973;Watt, 1975).…”