Reactive and non-reactive species formed during the methanolysis of NaBH<sub>4</sub>: a theoretical and experimental approach

Orrego, Alejandro Vallejo; Ferretti, Cristián A.; Díez, Verónica Karina

doi:10.1039/d3re00007a

Cited by 2 publications

(2 citation statements)

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“…8,9 The methanolysis of NaBH 4 is also an exothermic process (ΔH methanolysis = −319 kJ/mol). 10 When working in batch, the exothermicity and decomposition are controlled by multiple additions of small portions of NaBH 4 at a low temperature. Nonetheless, this methodology results in long reaction times which are costly and energy intensive at large scale and suffer from low repeatability.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, reductions with NaBH 4 are generally conducted in protic solvents such as methanol or ethanol due to the high solubility of NaBH 4 in them. However, its efficiency in these solvents is poor due to the high decomposition rate at room temperature. , The methanolysis of NaBH 4 is also an exothermic process (Δ H methanolysis = −319 kJ/mol) . When working in batch, the exothermicity and decomposition are controlled by multiple additions of small portions of NaBH 4 at a low temperature.…”

Section: Introductionmentioning

confidence: 99%

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Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH₄ Solutions: Toward Implementation of Luche Reduction in Flow

Bernardin,

Philippe,

Vanoye

et al. 2024

Ind. Eng. Chem. Res.

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Carbonyl reductions using NaBH 4 are generally high-yielding and highly selective processes commonly used in organic synthesis and the pharmaceutical industry. However, the reaction is exothermic, and the stability of the NaBH 4 solution is limited, resulting in long reaction times at a controlled temperature in batch reactors, which are costly and energy-intensive on a large scale. Due to the low solubility of NaBH 4 or lack of stability of NaBH 4 solution in protic solvents, this reducing agent is underutilized in flow synthesis. In this work, efficient reductions of ketones and aldehydes are reported for the first time in a continuous advanced-flow reactor using stabilized solutions of NaBH 4 within short residence times (between 20 and 80 s) at 60 °C. This methodology was also successfully applied to perform a straightforward and easy-to-handle continuous chemoselective reduction of α,β-unsaturated carbonyl compounds in the presence of cerium(III) chloride in methanol (i.e., Luche reduction).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH₄ Solutions: Toward Implementation of Luche Reduction in Flow

Bernardin,

Philippe,

Vanoye

et al. 2024

Ind. Eng. Chem. Res.

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Development of Al2O3-supported nanobimetallic Co-La-B catalyst for boosting hydrogen release via sodium borohydride hydrolysis

Keskin,

Horoz,

Şahin

et al. 2024

J Aust Ceram Soc

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This study introduces the novel Al2O3-supported nanobimetallic Co-La-B (Al2O3@Co-La-B) catalyst, specifically designed to enhance hydrogen production via sodium borohydride hydrolysis, marking its first application in hydrogen generation. Characterized by X-ray diffraction, Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, Brunauer–Emmett–Teller analysis, and scanning electron microscopy, the catalyst exhibits a porous, homogeneous cubic structure which significantly contributes to its high catalytic efficiency. It demonstrated remarkable hydrogen generation rates of up to 6057.72 mLH2 min−1 gcat−1 at 30 °C and maintained 91.63% catalytic activity over multiple cycles, with a notable increase to 8661.94 mLH2 min−1 gcat−1 at 60 °C. Kinetic studies, utilizing nth-order and Langmuir–Hinshelwood models, indicated activation energies of 51.38 kJ mol−1 and 49.33 kJ mol−1, respectively, showcasing the catalyst's potential as a sustainable solution for hydrogen production in various industrial applications.

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Reactive and non-reactive species formed during the methanolysis of NaBH₄: a theoretical and experimental approach

Abstract: The formation, stability, and reactivity of the species generated by the reduction reaction of solid NaBH4 with methanol in the liquid phase were investigated by experimental FTIR studies and Density...

Cited by 2 publications

References 46 publications

Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH₄ Solutions: Toward Implementation of Luche Reduction in Flow

Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH₄ Solutions: Toward Implementation of Luche Reduction in Flow

Development of Al2O3-supported nanobimetallic Co-La-B catalyst for boosting hydrogen release via sodium borohydride hydrolysis

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Reactive and non-reactive species formed during the methanolysis of NaBH4: a theoretical and experimental approach

Abstract: The formation, stability, and reactivity of the species generated by the reduction reaction of solid NaBH4 with methanol in the liquid phase were investigated by experimental FTIR studies and Density...

Cited by 2 publications

References 46 publications

Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH4 Solutions: Toward Implementation of Luche Reduction in Flow

Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH4 Solutions: Toward Implementation of Luche Reduction in Flow

Development of Al2O3-supported nanobimetallic Co-La-B catalyst for boosting hydrogen release via sodium borohydride hydrolysis

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Reactive and non-reactive species formed during the methanolysis of NaBH₄: a theoretical and experimental approach

Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH₄ Solutions: Toward Implementation of Luche Reduction in Flow

Continuous Flow Process for Carbonyl and α,β-Unsaturated Carbonyl Compounds Reduction Using NaBH₄ Solutions: Toward Implementation of Luche Reduction in Flow