Reactive arthritis associated with Mycoplasma genitalium urethritis

Chrisment, D.; Machelart, Irène; Wirth, G.; Lazaro, Estibaliz; Greib, C.; Pellegrin, JL; Bebear, Cécile; Peuchant, Olivia

doi:10.1016/j.diagmicrobio.2013.07.015

Cited by 11 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given the association of C. trachomatis with postinfectious arthritis, there is a possibility that M. genitalium would be associated with this or other syndromes involving joint inflammation [61,62]. Although Horner et al had reported that M. genitalium is associated with balanoposthitis, such an association was not observed in the recent study by Ito et al [43,63].…”

Section: Syndromes Possibly Associated With M Genitaliummentioning

confidence: 96%

Mycoplasma genitalium Infection in Men

Horner

Martín

2017

The Journal of Infectious Diseases

109

103

View full text Add to dashboard Cite

Mycoplasmagenitalium is one of the major causes of nongonococcal urethritis (NGU) worldwide but an uncommon sexually transmitted infection (STI) in the general population. The risk of sexual transmission is probably lower than for Chlamydia trachomatis. Infection in men is usually asymptomatic and it is likely that most men resolve infection without developing disease. The incubation period for NGU caused by Mycoplasma genitalium is probably longer than for NGU caused by C. trachomatis. The clinical characteristics of symptomatic NGU have not been shown to identify the pathogen specific etiology. Effective treatment of men and their sexual partner(s) is complicated as macrolide antimicrobial resistance is now common in many countries, conceivably due to the widespread use of azithromycin 1 g to treat STIs and the limited availability of diagnostic tests for M. genitalium. Improved outcomes in men with NGU and better antimicrobial stewardship are likely to arise from the introduction of diagnostic M. genitalium nucleic acid amplification testing including antimicrobial resistance testing in men with symptoms of NGU as well as in their current sexual partner(s). The cost effectiveness of these approaches needs further evaluation. The evidence that M. genitalium causes epididymo-orchitis, proctitis, and reactive arthritis and facilitates human immunodeficiency virus transmission in men is weak, although biologically plausible. In the absence of randomized controlled trials demonstrating cost effectiveness, screening of asymptomatic men cannot be recommended.

show abstract

Section: Syndromes Possibly Associated With M Genitaliummentioning

confidence: 96%

Mycoplasma genitalium Infection in Men

Horner

Martín

2017

The Journal of Infectious Diseases

109

103

View full text Add to dashboard Cite

show abstract

“…A possible association of reactive arthritis with M. genitalium urethritis has been described in the literature [1, 57, 58], but further studies of its role in symptoms occurring at extragenital sites are needed.…”

Section: Clinical Featuresmentioning

confidence: 99%

Mycoplasma genitalium: A Review

Gnanadurai

Fifer

2020

Microbiology

View full text Add to dashboard Cite

Mycoplasma genitalium is a fastidious organism of the class Mollicutes, the smallest prokaryote capable of independent replication. First isolated in 1981, much is still unknown regarding its natural history in untreated infection. It is recognized as a sexually transmitted pathogen causing acute and chronic non-gonococcal urethritis (NGU) in men, with a growing body of evidence to suggest it also causes cervicitis and pelvic inflammatory disease in women. Its role in several other clinical syndromes is uncertain. The majority of people infected remain asymptomatic and clear infection without developing disease; asymptomatic screening is therefore not recommended. Prevalence rates are higher in patients attending sexual health clinics and in men with NGU. Limited availability of diagnostics has encouraged syndromic management, resulting in widespread antimicrobial resistance and given that few antimicrobial classes have activity against M. genitalium , there is significant concern regarding the emergence of untreatable strains. There is a need for wider availability of testing, which should include detection of macrolide resistance mediating mutations. Expertise in interpretation of microbiological results with clinical correlation ensures targeted treatment avoiding unnecessary antibiotic exposure. Public health surveillance nationally and internationally is vital in monitoring and responding to changing epidemiology trends. In this review, we summarize current knowledge of M. genitalium , including epidemiology, clinical and microbiological data, and discuss treatment challenges in the era of rising multidrug resistance.

show abstract

“…12 Mycoplasma genitalium has also been rarely associated with the condition as it has been isolated from the joints of patients with ReA, but its true incidence remains unknown. 13,14 In general, post-venereal ReA is most commonly found in young men, with the peak onset observed during the third decade of life. The male-to-female ratio for post-venereal ReA has been estimated to range from 5 : 1 to 10 : 1.…”

Section: Epidemiology-etiologymentioning

confidence: 99%

“…In Norway, an annual incidence of 4.6 cases per 100 000 population for chlamydial ReA and an incidence of five cases per 100 000 population for enteric bacteria‐induced ReA were reported in 1988–1990 . Mycoplasma genitalium has also been rarely associated with the condition as it has been isolated from the joints of patients with ReA, but its true incidence remains unknown …”

Section: Epidemiology‐etiologymentioning

confidence: 99%

Reactive Arthritis

Stavropoulos

Soura

Κανελλέας

et al. 2014

Acad Dermatol Venereol

View full text Add to dashboard Cite

Reactive arthritis (ReA) is an immune-mediated seronegative arthritis that belongs to the group of spondyloarthropathies and develops after a gastrointestinal or genitourinary system infection. The condition is considered to be characterized by a triad of symptoms (conjunctivitis, arthritis and urethritis) although a constellation of other manifestations may also be present. ReA is characterized by psoriasiform dermatological manifestations that may resemble those of pustular psoriasis and, similar to guttate psoriasis, is a post-infectious entity. Also, the articular manifestations of the disorder are similar to those of psoriatic arthritis and both conditions show a correlation with HLA-B27. These facts have led several authors to suggest that there is a connection between ReA and psoriasis, listing ReA among the disorders related to psoriasis. However, the pathogenetic mechanism behind the condition is complex and poorly understood. Bacterial antigenicity, the type of host response (i.e. Th1/Th2 imbalance) and various genetic factors (i.e. HLA-B27 etc.) play an important role in the development of the disorder. It is unknown whether all the aforementioned factors are part of a mechanism that could be similar to, or share basic aspects with known psoriasis pathogenesis mechanisms.

show abstract

Reactive arthritis associated with Mycoplasma genitalium urethritis

Cited by 11 publications

References 14 publications

Mycoplasma genitalium Infection in Men

Mycoplasma genitalium Infection in Men

Mycoplasma genitalium: A Review

Reactive Arthritis

Contact Info

Product

Resources

About