Reactive Extraction of Beta-Lactam Antibiotics: Ir Spectroscopic Studies

Bora, M. M.; Dutta, Narendra Nath; Tosh, B.; Bhattacharya, K. G.

doi:10.1080/00986440008912204

Cited by 5 publications

(7 citation statements)

References 4 publications

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“…It is also known that four‐membered ring ketones appear at about 1780 cm − 1 (20). The peak at 1670 cm − 1 is due to the secondary amide (‐CONH‐) present in penicillin G, which does not show any shifting in frequency, indicating no change in chemical environment of this group during complexation (19, 22). Salts of secondary amines give an N + H 2 bending vibration in the 1650–1560 cm − 1 (19) or 1620–1560 cm − 1 (23) range.…”

Section: Resultsmentioning

confidence: 99%

Reaction Equilibrium of Penicillin G with Amberlite LA‐2 in a Nonpolar Organic Solvent

Lee

Ahn

Kim³

2002

Biotechnology Progress

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Studies have been made of the reactive extraction of penicillin G by Amberlite LA-2, a secondary amine, dissolved in kerosene. On the basis of the previous works about extraction equilibria of monocarboxylic acids by some secondary amines in low polar organic solvents, four equilibrium models were suggested to describe the reaction equilibrium of penicillin G in the liquid-liquid extraction system. The calculated results from the models were compared with the experimental data of 96 runs, and only two equilibrium models seemed to be probable. Ultimately, the most reasonable extraction equilibrium model was chosen through spectroscopic studies on organic solutions obtained by five specific extraction equilibrium experiments.

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Section: Resultsmentioning

confidence: 99%

Reaction Equilibrium of Penicillin G with Amberlite LA‐2 in a Nonpolar Organic Solvent

Lee

Ahn

Kim³

2002

Biotechnology Progress

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“…The QCl solutions were prepared in hexane as the solvent at concentration 1, 5, 10, 15 mmol L −1 . The basis for selection of hexane was its relative low toxicity and the findings of previous studies that it provides optimum extraction equilibrium for such systems .…”

Section: Methodsmentioning

confidence: 99%

“…Bora et al . has reported reactive extraction of certain β‐lactum antibiotics with Aliquat‐336. Organic solvent used in reactive extraction process may be easily recovered in the re‐extraction step and can be successively used.…”

Section: Introductionmentioning

confidence: 99%

“…Hano et al [6] used tri-n-octylmethylammonium chloride for recovery of cephalosporin C. Cascaval et al [8] applied this technique using D2EHPA for selective separation of gentamicins from biosynthetic mixture. Bora et al [7,9] has reported reactive extraction of certain b-lactum antibiotics with Aliquat-336. Organic solvent used in reactive extraction process may be easily recovered in the re-extraction step and can be successively used.…”

Section: Introductionmentioning

confidence: 99%

“…In order to circumvent the issue, reactive extraction, i.e., extraction with chemical reaction will be highly useful. Reactive extraction is reported to be an effective method for selective separation of certain compounds such as carboxylic acid, antibiotics, etc., from their mixture . Common extraction agents, the so‐called carriers are D2EHPA, primary, secondary, tertiary, and quaternary amine, etc.…”

Section: Introductionmentioning

confidence: 99%

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Separation of norbixin from Bixa orellana seed raw dye by Aliquat‐336

Sharma

Bora

Borthakur

et al. 2012

Env Prog and Sustain Energy

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The reactive extraction of Bixa orellana seed pigment norbixin with cationic carrier Aliquat‐336 (QCl) in a two phase system has been studied. A raw alkali extract of Bixa orellana pigments in 0.5% sodium hydroxide solution is used as aqueous phase and Aliquat‐336 dissolved in hexane as solvent is used as the organic phase. In the aqueous alkaline phase, the pigment (bixin + norbixin) exists as sodium norbixinate in ionized form. This sodium norbixinate forms complex with QCl by an ion‐exchange mechanism which is pH dependent. Re‐extraction occurs via another ion‐exchange reaction with H+ ion with another aqueous phase of low pH. Complexation expressed as degree of extraction increases with pH reaching almost an asymptotic whereafter tends to decrease slightly. Around 99% recovery of norbixin as its complex with Aliquat‐336 was achieved at an organic phase to aqueous phase volume ratio 2:1. 98% of the norbixin‐QCl complex was recovered as norbixin in aqueous solution at pH 4. The results of this investigation may be considered reasonable to believe that reactive extraction is likely to provide an attractive and alternative separation method for the recovery of norbixin. © 2011 American Institute of Chemical Engineers Environ Prog, 32: 134–138, 2013.

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