Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract

Maguilnik, Ismael; Neumann, William L.; Sonnenberg, Amnon; Genta, Robert M.

doi:10.1111/apt.12031

Cited by 30 publications

(32 citation statements)

References 35 publications

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“…In a large cross‐sectional study of >500 000 biopsies, the overall prevalence of reactive gastropathy (which included FH) was 15%. However, in children <10 years of age, this prevalence was ~2%, while in adults >80 years of age, it was >20% …”

Section: Introductionmentioning

confidence: 94%

“…In adults, the features of FH are often felt to be synonymous with chemical gastropathy, as they were initially described in bile reflux gastritis . In addition to duodenogastric bile reflux, the most common causes of FH include alcohol and medications, frequently nonsteroidal anti‐inflammatory drugs . In a large cross‐sectional study of >500 000 biopsies, the overall prevalence of reactive gastropathy (which included FH) was 15%.…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia

et al. 2018

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia

et al. 2018

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“…[9,12] In our own population, reactive gastropathy was significantly associated with Barrett's mucosa, duodenitis, duodenal intraepithelial lymphocytosis, active ileitis, focal active colitis, and collagenous colitis, but none of these associations was strong or affected a large subgroup of patients. [13] In the majority of cases, the occurrence of reactive gastropathy remains unexplained. It may reflect the effect of cumulative exposure of the gastric mucosa to other yet unidentified nutritional or environmental toxins over a prolonged time period.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Changes in the Gastric Mucosa With Aging

Sonnenberg

Genta

2015

Clinical Gastroenterology and Hepatology

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“…This could explain why they increasingly are seen arising in a background of reactive gastropathy. 29 …”

Section: Hyperplastic Polypsmentioning

confidence: 99%

Management of Gastric Polyps: An Endoscopy-Based Approach

Shaib

Rugge

Graham

et al. 2013

Clinical Gastroenterology and Hepatology

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The endoscopic finding of a gastric polyp and the histopathologic report that follows may leave clinicians with questions that have not been addressed in formal guidelines: do all polyps need to be excised, or can they just be sampled for biopsy? If so, which ones and how many should be sampled? What follow-up evaluation is needed, if any? This review relies on the existing literature and our collective experience to provide practical answers to these questions. Fundic gland polyps, now the most frequent gastric polyps in Western countries because of widespread use of proton pump inhibitors, and hyperplastic polyps, the second most common polyps notable for their association with gastritis and their low but important potential for harboring dysplastic or neoplastic foci, are discussed in greater detail. Adenomas have had their name changed to raised intraepithelial neoplasia and are decreasing in parallel with Helicobacter pylori infection; however, they do retain their importance as harbingers of gastric cancer, particularly in East Asia. Gastrointestinal stromal tumors have low incidence and no known associations, but their malignant potential is high; early diagnosis and proper management are crucial. Although rare and benign, inflammatory fibroid polyps need to recognized, particularly by pathologists, to avoid misdiagnosis. Gastric neuroendocrine tumors (carcinoids) are important because of their association with either atrophic gastritis or the multiple endocrine neoplasia syndromes; those that do not arise in these backgrounds have high malignant potential and require aggressive management. The review concludes with some practical suggestions on how to approach gastric polyps detected at endoscopy.

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Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract

Abstract: SUMMARY BackgroundThe epidemiology of reactive gastropathy and its relationship with other conditions of the gastrointestinal tract associated with NSAID use have not been evaluated.

Cited by 30 publications

References 35 publications

Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia

Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia

Changes in the Gastric Mucosa With Aging

Management of Gastric Polyps: An Endoscopy-Based Approach

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