Reactive liquid chromatography

Borren, T.; Fricke, Jöorg; Schmidt–Traub, H.

doi:10.1007/3-540-30304-9_5

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…In the pharmaceutical industry enantiomeric mixtures are expensive substances of which only one is the product while the other must be racemized again in order to reduce production cost. For the razemization of Troegers Base, BORREN et al [19,108] found that the HCR process is advantageous compared to sequential process of a reactor followed by SMB separation if high yields are favorable but offers no advantage if productivity is to optimized. For optimal process design it is also recommended to separate the product at the extract port.…”

Section: Application Of Liquid Chromatographic Reactorsmentioning

confidence: 99%

Chromatographic Reactors

Fricke¹,

Schmidt–Traub²,

Schembecker³

2008

Ullmann's Encyclopedia of Industrial Chemistry

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Chromatographic reactors integrate chemical reaction and chromatographic separation in one apparatus. This offers potential for process intensification, especially in the case of equilibrium reactions. Different types of discontinuous and continuous processes as well as modeling of chromatographic reactors are described. Synthesis and design of this processes is very much influenced and often restricted by the type of reaction and the operating window which is set by the individual operating conditions for chemical reaction, mass separation, and equipment design. Integrated chromatographic reactors should be considered if chromatography is the favored separation process for a conventional sequential process design. Preparative chromatographic reactors are known for liquid‐ and gas‐phase processes. Laboratory‐scale applications are described. Analytical chromatographic reactors are used to determine reaction rate constants and kinetics, and to screen chromatographic systems and operating conditions for preparative applications. 1. Introduction 2. Types of Chromatographic Reactors 3. Modeling of Chromatographic Reactors 3.1. Adsorption Isotherm and Reaction Kinetics 3.2. Modeling the BCR 3.3. Modeling Simulated Moving Bed Chromatographic Reactors 3.4. Process control 4. Synthesis of Preparative Chromatographic Reactors 4.1. Process Principles 4.2. Type of Reaction 5. Design of Preparative Chromatographic Reactors 5.1. Design of the Process 5.2. Choice of Operating Conditions 6. Preparative Chromatographic Reactors 6.1. Applications of Gas Chromatographic Reactors 6.2. Application of Liquid Chromatographic Reactors 7. Analytical Chromatographic Reactors 7.1. Determination of Rate Constants 7.2. Enzymatic Reactions 7.3. Characterization of the Stationary Phase 7.4. Examination of Fast Equilibrium Reactions 7.5. Examination of Solvent Effects

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Section: Application Of Liquid Chromatographic Reactorsmentioning

confidence: 99%

Chromatographic Reactors

Fricke¹,

Schmidt–Traub²,

Schembecker³

2008

Ullmann's Encyclopedia of Industrial Chemistry

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“…Ebbers et al gives an overview of racemizable classes of molecules. The concept Figure c was considered, for example, applying thermal racemization of Troeger’s base and chlorthalidone, as well as enzymatic racemization of amino acids. − …”

Section: Advanced Process Conceptsmentioning

confidence: 99%

Evaluation of Competing Process Concepts for the Production of Pure Enantiomers

Kaspereit

Swernath

Kienle

2012

Org. Process Res. Dev.

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Various promising concepts exist for improving the performance of productions of pure enantiomers. An efficient approach is developed for the systematic conceptual design of such processes. The proposed three-step procedure aids a fast selection of the optimal process configuration out of many possible candidates and leads to an optimally designed process. The approach is applied in a case study for an industrially relevant compound, considering different process concepts based on simulated moving bed chromatography, enantioselective crystallization, and racemization. It is demonstrated that mixed-integer nonlinear programming is capable of predicting simultaneously the optimal process configuration and optimal design parameters.

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“…with appropriate initial and boundary conditions. The adsorption equilibrium and the reaction kinetics have been determined experimentally in Borren et al (2006). The adsorption equilibrium can be described by an asymmetric multi-component Langmuir isotherm…”

Section: Process Description and Process Modelmentioning

confidence: 99%