Reactive Oxygen Species and Diabetic Nephropathy

Lee, Hi Bahl; Ha, Hunjoo; King, George L.

doi:10.1097/01.asn.0000077403.06195.d2

Cited by 19 publications

(6 citation statements)

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“…Hyperglycaemia leads to the generation of advanced glycation end products (AGEs) [2], which interact with a number of cellular receptors including the receptor for AGE (RAGE) [3]. Recent evidence suggests that AGE-RAGE interaction activates the vascular NAD(P)H oxidase complex resulting in the production of reactive oxygen species (ROS) [4], which is believed to play a pivotal role in the pathogenesis of DN [5]. NAD(P)H oxidase was originally discovered in neutrophils [6].…”

Section: Introductionmentioning

confidence: 99%

Relationship between common functional polymorphisms of the p22phox gene (−930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population

et al. 2006

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Section: Introductionmentioning

confidence: 99%

Relationship between common functional polymorphisms of the p22phox gene (−930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population

et al. 2006

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“…Diabetes is accompanied by neutrophil malfunction caused, to a large extent, by the development of oxidative-nitrative stress [90]. Oxidative stress leads to the activation of immunocompetent blood cells and their aggregation and adhesion.…”

Section: Influence Of Galega Officinalis On Functional State Of Leuko...mentioning

confidence: 99%

Galega officinalisL. and Immunological Status in Diabetes Mellitus

Nagalievska¹,

Hachkova²,

Sybirna³

2020

Metformin

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Under diabetes mellitus, the administration of Galega officinalis promotes restoration of leukocyte precursors' bone marrow pool and normalizes their proliferative activity. This plant protects the functional state of leukocytes by modulating actin cytoskeleton formation and through quantitative redistribution of leukocyte membrane glycoconjugates. Galega officinalis prevents the development of diabetesassociated oxidative stress which results in antiapoptotic activity. The normalization of leukocytes' proliferative and functional capacity by Galega officinalis, along with its antiapoptotic and hypoglycemic effects, can improve the course of the disease and may prevent the development of complications of diabetes.

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“…For instance, ROS can directly damage the DNA and can also alter the expression of ECM glycoproteins. The altered glycoproteins can undergo glycation to form AGEs that can also invariably cause oxidant stress by transducing various intracellular mechanisms via activation of their receptors (RAGE), suggesting that oxidant stress may be the common denominator in the pathogenesis of various complications, as is the case in adult life [12,13,14]. Increased production of ROS related to glucose metabolism could be due to increased oxidative phosphorylation, increased superoxide generation [15] and the relative immaturity of the free radical scavenging system [16], as well as inhibition of free radical scavenging pathways [17].…”

Section: Pathogenetic Mechanisms Relevant To Diabetic Complications Imentioning

confidence: 99%

“…Although ROS are regarded as the common denominator and are pivotal to the development of diabetic complications in adult life [12,13,14], their direct role in diabetic embryopathy is somewhat debatable. An increased production of reactive oxygen species (ROS) is thought to contribute to the development of diabetic vascular complications in adults [18,19,20,21,22,23], since the embryonic tissues are readily susceptible to oxidative damage by ROS, resulting in various congenital abnormalities, including neural tube or genitourinary defects.…”

Section: Pathogenetic Mechanisms Relevant To Diabetic Complications Imentioning

confidence: 99%

Hyperglycemia: its imminent effects on mammalian nephrogenesis

et al. 2005

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A sustained exposure of the mammalian embryo to very high glucose ambience is associated with a multitude of congenital birth defects, including those of the cardiovascular, CNS, skeletal and urogenital systems during the first 6-8 weeks of gestation in humans. These urogenital abnormalities may be associated with "caudal regression syndrome" or may occur alone in the form of partial or total renal agenesis. Similarly, an increase in the incidence of morphogenetic defects is observed in the offspring of streptozotocin-induced diabetic rats and mice, and also in non-obese diabetic mice. In certain cases, failure during the growth of the lower parts of embryos or newborn mice involving the genitourinary system has been observed in animals with severe diabetes. Investigators have utilized whole organ culture systems to delineate the mechanisms relevant to dysmorphogenesis of the embryonic metanephros. A marked dysmorphogenesis of the metanephros is observed upon treatment with a high concentration of D: -glucose. Associated with it are changes that include branching dysmorphogenesis of the ureteric bud iterations, reduced population of nascent nephrons, decreased expression of basement membrane proteoglycans, depletion of ATP stores, and fulminant apoptosis of the cells at the interface of mesenchyme and ureteric bud epithelium. The latter findings suggest that disruption of epithelial:mesenchymal interactions may be the major event responsible for the metanephric dysmorphogenesis induced by high glucose ambience.

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Reactive Oxygen Species and Diabetic Nephropathy

Cited by 19 publications

References 0 publications

Relationship between common functional polymorphisms of the p22phox gene (−930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population

Relationship between common functional polymorphisms of the p22phox gene (−930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population

Galega officinalisL. and Immunological Status in Diabetes Mellitus

Hyperglycemia: its imminent effects on mammalian nephrogenesis

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