Reactive oxygen species-based nanotherapeutics for head and neck squamous cell carcinoma

Zhang, Shichen; Li, Zhengqiang; Xu, Zhimin; Tang, Yixin; Duan, Congcong; Dai, Huanyan; Dai, Xinyu; Wei, Xin; Liu, Yan; Xu, Caina; Han, Bing

doi:10.1016/j.matdes.2022.111194

Cited by 7 publications

(3 citation statements)

References 169 publications

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“…Moderate and high levels of ROS accumulation promote cancer, and these ROS also cause cell death via the apoptosis, necrosis, autophagy, and ferroptosis pathways. H 2 O 2 and nanoparticle treatments were found to inhibit Escherichia coli 2.5 and 5 times more than when left untreated, respectively. − ROS formation in some metal oxide NPs, such as ZnO NPs, can be enhanced by visible and ultraviolet (UV) light . CuO NP exposure contributes to apoptosis and redox stress .…”

Section: The Mechanism Of Mnps In Antimicrobial Activitiesmentioning

confidence: 99%

Metal-Based Nanoparticles as Antimicrobial Agents: A Review

Luo,

Huang,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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Antibiotic abuse has become a rising public health concern in recent years, leading to dangerous bacteria developing antibiotic resistance to most antibiotic medicines currently in use. Traditional antimicrobial medications have been helpful in the early stages of treating numerous forms of serious bacterial infectious diseases; however, despite the significant therapeutic benefit, there are a number of issues with follow-up treatment. Metalbased nanomaterials, which have properties including the difficulty of establishing drug resistance and the advantages of reduced cytotoxicity, have been considered promising antimicrobial substances. This review discusses the most important types of metal-based nanoparticles (MNPs), such as copper, titanium, zinc oxide, etc., with a focus on the antimicrobial applications of gold-and silver-based nanoparticles. Furthermore, the advanced research progress of MNPs as antimicrobial agents and the stimuli-responsive metal nanoparticle antimicrobial strategies working under photothermal, magnetic, and pH stimulation are also summarized in this article. In general, with the advancement of technology, antimicrobial materials based on MNPs will offer excellent prospects for improving drug resistance and antimicrobial applications.

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Section: The Mechanism Of Mnps In Antimicrobial Activitiesmentioning

confidence: 99%

Metal-Based Nanoparticles as Antimicrobial Agents: A Review

Luo,

Huang,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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“… 10 This process triggers the photosensitizer to generate reactive oxygen species, which selectively eradicate abnormal cells. 11 By precisely targeting the affected cells, this technique mitigates the risk of harm to healthy tissue, thereby enhancing treatment efficacy. 12 Furthermore, the utilized imaging system guarantees accurate and effective identification of cervical lesions correlated with HPV.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules

Shanazarov,

Zare,

Mussin

et al. 2024

Therapeutic Advances in Chronic Disease

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Background: Cervical cancer poses a considerable worldwide health issue, where infection with the human papillomavirus (HPV) plays a vital role as a risk factor. Photodynamic therapy (PDT) is a minimally invasive treatment for HPV-related cervical lesions, which uses photosensitizers and light to selectively destroy abnormal cells. Objectives: Our objective is to present a comprehensive overview of the different types of molecules employed in PDT to reduce the occurrence and fatality rates associated with cervical cancer. Design: Scoping review and bibliometric analysis. Methods: The article explores clinical trials investigating the efficacy of PDT in treating low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion, as well as preclinical approaches utilizing various molecules for PDT in cervical cancer. Furthermore, the article sheds light on potential molecules for PDT enhancement, examining their properties through computer modeling simulations, molecular docking, and assessing their advantages and disadvantages. Results: Our findings demonstrate that PDT holds promise as a therapeutic approach for treating cervical lesions associated with HPV and cervical cancer. Additionally, we observe that the utilization of diverse dye classes enhances the anticancer effects of PDT. Conclusion: Among the various molecules employed in PDT, functionalized fullerene exhibits a notable inclination toward overexpressed receptors in cervical cancer cells, making it a potential candidate for intensified use in PDT. However, further research is needed to evaluate its long-term effectiveness and safety.

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“…During that procedure, the cervix is covered with PS, and the target area is exposed to a specific wavelength of light [6]. This process triggers PS to generate the reactive oxygen species that selectively destroy abnormal cells [7]. By precisely targeting the affected cells, this method reduces the risk of damage to healthy tissues, thereby increasing the effectiveness of treatment [8].…”

mentioning

confidence: 99%

Photodynamic Therapy for Cervical Cancer: A Literature Review

Shanazarov,

Bariyeva,

Mussin

et al. 2023

Onkol. radiol. Kaz.

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Relevance: Cervical cancer is a major public health problem worldwide, with human papillomavirus infection playing a vital role as a risk factor. Photodynamic therapy is a minimally invasive treatment for HPV-related cervical lesions that uses photosensitizers and light to selectively destroy abnormal cells. The study aimed to comprehensively review the different types of molecules used in PDT to reduce the morbidity and mortality associated with cervical cancer. Methods: A comprehensive search was conducted for all relevant articles investigating the efficacy and safety of PDT in the treatment of HPV-associated cervical cancer. PICO scores were determined for the review, and a literature search of the PubMed database was performed. An examination of the PubMed online database using keyword combinations identified 71 studies conducted between 2013 and 2023 that investigated using PDT to treat RSM cells. This article reviews ongoing clinical trials examining the efficacy of PDT in treating low-grade squamous cell intraepithelial neoplasia and high-grade squamous cell intraepithelial lesions, as well as preclinical approaches using different molecules for PDT in cervical cancer Results: Potential molecules for PDT are described, their advantages and disadvantages evaluated, and solutions to improve their compatibility with antitumor treatment are proposed. Our review shows that PDT is a promising therapeutic approach for diagnosing and treating HPV-related cervical lesions. At the same time, we observe that using different classes of dyes enhances the anticancer effects of PDT Conclusion: Fullerene and ALA-PDT are potential leaders for more intensive use in PDT, which will further help reduce the global incidence and mortality from cervical cancer. However, further studies are needed to evaluate its long-term efficacy and safety.

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Reactive oxygen species-based nanotherapeutics for head and neck squamous cell carcinoma

Cited by 7 publications

References 169 publications

Metal-Based Nanoparticles as Antimicrobial Agents: A Review

Metal-Based Nanoparticles as Antimicrobial Agents: A Review

Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules

Photodynamic Therapy for Cervical Cancer: A Literature Review

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