Reactive Oxygen Species: Potential Regulatory Molecules in Response to Hypomagnetic Field Exposure

Zhang, Bingfang; Tian, Lanxiang

doi:10.1002/bem.22299

Cited by 34 publications

(19 citation statements)

References 68 publications

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“…Another possibility is based on the radical pair mechanism, which depends on the interconversion of a radical pair between the singlet state and the triplet state (Lambert et al, 2013). Considering that a radical pair is generated in several metabolic processes, one may adopt this mechanism to explain the HMF effect (Zhang and Tian, 2020). Evaluating these two possibilities is a subject for future studies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells

Srimai¹,

Kiatarkom²,

Miyata³

2020

IJC

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Hypo-magnetic fields (HMFs) are static magnetic fields that are significantly weaker than the geomagnetic field and are found in interplanetary space, on Mars, and the Moon. Understanding the mechanism of the biological effects of HMFs is an important topic in magnetobiology. Human physiology studies have shown that HMFs cause various adverse health effects such as increased blood pressure and blood flow rate. Previous studies on the effects of HMFs on cells revealed a variety of effects, such as a change in growth rate, a decrease in mitochondrial membrane potential, and an increase in reactive oxygen species. A decrease in mitochondrial membrane potential (DFm) may seriously impair cellular activity by interfering with the production of ATP. Thus, a deeper investigation of the effects of HMFs on mitochondrial function could provide clues to understanding the adverse effects of HMFs. In the present study, we used mouse macrophage RAW264 cells to investigate the effects of an HMF on mitochondrial membrane potential, mitochondrial superoxide anion (O2-) production, and cell proliferation.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells

Srimai¹,

Kiatarkom²,

Miyata³

2020

IJC

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“…Earth's geomagnetic field, ranging from approximately 24 to 66 μT depending on latitude [147], can have critical roles in numerous biological processes. Shielding the geomagnetic field, called hypomagnetic field, is known to cause biological effects [19,21,23,[148][149][150][151][152].…”

Section: Hypomagnetic Fieldmentioning

confidence: 99%

Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi

Simon

2022

J. R. Soc. Interface.

102

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Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, the magnetic energies implicated in these effects are much smaller than thermal energies. Here, we review these observations, and we suggest an explanation based on the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of transient radical molecules. While the radical pair mechanism has been studied in detail in the context of avian magnetoreception, the studies reviewed here show that magnetosensitivity is widespread throughout biology. We review magnetic field effects on various physiological functions, discussing static, hypomagnetic and oscillating magnetic fields, as well as isotope effects. We then review the radical pair mechanism as a potential unifying model for the described magnetic field effects, and we discuss plausible candidate molecules for the radical pairs. We review recent studies proposing that the radical pair mechanism provides explanations for isotope effects in xenon anaesthesia and lithium treatment of hyperactivity, magnetic field effects on the circadian clock, and hypomagnetic field effects on neurogenesis and microtubule assembly. We conclude by discussing future lines of investigation in this exciting new area of quantum biology.

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“…Earth's geomagnetic field, ranging from ∼24 to ∼66 µT depending on latitude 144 , can have critical roles in numerous biological processes. Shielding the geomagnetic field, called hypomagnetic field, is known to cause biological effects 19,22,24,[145][146][147][148][149] .…”

Section: Hypomagnetic Fieldmentioning

confidence: 99%

Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi¹,

Simon²

2022

Preprint

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A large and growing body of research shows that weak magnetic fields can significantly influence various biological systems, including plants, animals, and humans. However, the underlying mechanisms behind these phenomena remain elusive. It is remarkable that the magnetic energies implicated in these effects are much smaller than thermal energies. Here we review these observations, of which there are now hundreds, and we suggest that a viable explanation is provided by the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of naturally occurring transient radical molecules. While the radical pair mechanism has been studied in detail in the context of avian magnetoreception, the studies reviewed here show that magnetosensitivity is widespread throughout biology. We review magnetic field effects on various physiological functions, organizing them based on the type of the applied magnetic fields, namely static, hypomagnetic, and oscillating magnetic fields, as well as isotope effects. We then review the radical pair mechanism as a potential unifying model for the described magnetic field effects, and we discuss plausible candidate molecules that might constitute the radical pairs. We review recent studies proposing that the quantum nature of the radical pairs provides promising explanations for xenon anesthesia, lithium effects on hyperactivity, magnetic field and lithium effects on the circadian clock, and hypomagnetic field effects on neurogenesis and microtubule assembly. We conclude by discussing future lines of investigation in this exciting new area of quantum biology related to weak magnetic field effects.

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Reactive Oxygen Species: Potential Regulatory Molecules in Response to Hypomagnetic Field Exposure

Cited by 34 publications

References 68 publications

Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells

Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells

Magnetic field effects in biology from the perspective of the radical pair mechanism

Magnetic field effects in biology from the perspective of the radical pair mechanism

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