Reactive Oxygen Species Responsive Naturally Occurring Phenolic-Based Polymeric Prodrug

Vetha, Berwin Singh Swami; Adam, Angela Guma; Tripathy, Nirmalya; Lee, Dongwon; Khang, Gilson

doi:10.1007/978-981-13-0950-2_15

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…[ 30 ] Available studies showed that HMP exerts excellent anti‐inflammatory, anti‐oxidative, and anti‐apoptotic effects. [ 31 ] Consequently, multi‐bioactive NMs with ROS‐responsive, ROS‐scavenging, and ROS‐triggerable bioactive molecule release capacities can be facilely engineered by integrating different functional modules into a hydrolysable cyclic scaffold.…”

Section: Resultsmentioning

confidence: 99%

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

Liu

Wang

et al. 2023

Adv Funct Materials

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There are still great challenges in promoting bone defect repair via regeneration strategies. In view of delayed bone healing due to local inflammation, herein, pathogenesis‐guided engineering of multi‐bioactive hydrogel therapy is proposed for bone regeneration, by simultaneously improving the osteoimmune environment and enhancing osteogenic differentiation of stem cells. After discovering the pivotal role of persistent inflammation and bone loss in the pathogenesis of periodontitis by transcriptomics, a multi‐bioactive nanotherapy based on self‐assembled nanomicelles (PP5 NMs) is first developed. PP5 NMs effectively rescue osteogenesis of human periodontal ligament cells under pathological conditions and promote bone formation in rats with mandibular or cranial bone defects. By integrating PP5 NMs, a pro‐osteogenic protein rhBMP9, and a hydrogel‐forming temperature‐responsive material, a multifunctional hydrogel therapy is further engineered, which can regulate the pro‐inflammatory/oxidative microenvironment and accelerate bone regeneration. The obtained multi‐bioactive hydrogel capable of co‐delivering and sustainedly releasing PP5 NMs and rhBMP9 displays excellent bone regeneration capability, by synergistic effects of inflammation‐resolving and pro‐osteogenic differentiation of stem cells. Mechanistically, this hydrogel therapy improves the osteoimmune environment by attenuating pathogenesis and enhancing stem cell differentiation via the TLR4/NF‐κB/HO‐1 axis and activating the Smad1/5/8 protein complex. The hydrogel is promising for treating different inflammatory bone diseases.

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Section: Resultsmentioning

confidence: 99%

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

Liu

Wang

et al. 2023

Adv Funct Materials

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“…Their polymeric micelles release an anticancer drug to cancer cells in an ROS/GSH-specific manner and efficiently target tumor tissues. Phenyl/aryl boronic acid has been also used to make nanoparticles for an ROSresponsive drug carrier system [23,[35][36][37]. Zhang et al reported that PBAP-conjugated β-cyclodextrin as an ROS-scavenging material was degraded in the presence of H 2 O 2 and can be used as a carrier for treatment of inflammation or other oxidative stress [23].…”

Section: Discussionmentioning

confidence: 99%

Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan-g-methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer

et al. 2020

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The aim of this study is to prepare reactive oxygen species (ROS)-sensitive nanophotosensitizers for targeted delivery of chlorin e6 (Ce6) and photodynamic tumor therapy. For this purpose, thiodipropionic acid (TDPA) was conjugated with phenyl boronic acid pinacol ester (PBAP) (TDPA-PBAP conjugates) and then the TDPA-PBAP conjugates were attached to the chitosan backbone of chitosan-g-methoxy poly(ethylene glycol) (ChitoPEG) copolymer (ChitoPEG-PBAP). Ce6-incorporated ChitoPEG-PBAP nanophotosensitizers have an ROS-sensitive manner in vitro. The size of ChitoPEG-PBAP nanoparticles increased or disintegrated in a responsive manner against H2O2 concentration. The Ce6 release rate from ChitoPEG-PBAP nanophotosensitizers also increased by adding H2O2. These results indicated that nanophotosensitizers have sensitivity against ROS and showed triggered Ce6 release behavior. ChitoPEG-PBAP nanophotosensitizers can be more efficiently internalized into cancer cells compared to Ce6 alone and then produce ROS in a more efficient manner. Furthermore, ChitoPEG-PBAP nanophotosensitizers suppressed the viability of cancer cells in vitro and tumor growth in vivo with higher efficacy compared to Ce6 alone. Furthermore, ChitoPEG-PBAP nanophotosensitizers were efficiently delivered to irradiated tumor tissues, indicating that ChitoPEG-PBAP nanophotosensitizers can be delivered to the tumor with ROS-sensitive manner. We suggest that a ChitoPEG-PBAP nanophotosensitizer is a promising candidate for photodynamic therapy of cancers.

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“…CPOx smart polymers incorporated with small molecule (containing diol functional groups) could generate polymers with prodrug capability. These polymers are fabricated into micro/nano formulations and used in various biomedical applications [ 4 ]. They effectively target macrophages in inflammation and other AAD.…”

Section: History Of Polyoxalate and Copolyoxalatementioning

confidence: 99%

“…Reactive species includes free radicals, reactive oxygen intermediates (hydrogen peroxide (H 2 O 2 ), superoxide (O 2 •– ), singlet oxygen ( 1 O 2 ), peroxyl (RO • 2 ), alloxyl (RO • ), the hydroxyl radical ( • OH), reactive nitrogen intermediates—nitric oxide (NO • ), and nitrogen dioxide (NO • 2 )) [ 4 ]. All the above-mentioned species are metabolic byproducts formed by the metabolism of oxygen in mitochondria ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

Vetha

Adam

Aileru

2021

IJMS

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Polyoxalate (POx) and copolyoxalate (CPOx) smart polymers are topics of interest the field of inflammation. This is due to their drug delivery ability and their potential to target reactive oxygen species (ROS) and to accommodate small molecules such as curcumin, vanilline, and p-Hydroxybenzyl alcohol. Their biocompatibility, ultra-size tunable characteristics and bioimaging features are remarkable. In this review we discuss the genesis and concept of oxylate smart polymer-based particles and a few innovative systemic delivery methods that is designed to counteract the inflammation and other aging-associated diseases (AADs). First, we introduce the ROS and its role in human physiology. Second, we discuss the polymers and methods of incorporating small molecule in oxalate backbone and its drug delivery application. Finally, we revealed some novel proof of concepts which were proven effective in disease models and discussed the challenges of oxylate polymers.

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Reactive Oxygen Species Responsive Naturally Occurring Phenolic-Based Polymeric Prodrug

Cited by 7 publications

References 47 publications

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan-g-methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer

Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

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