Reactive poly(glycidyl methacrylate) microspheres prepared by dispersion polymerization

Horák, Daniel; Shapoval, Pavlo

doi:10.1002/1099-0518(20001101)38:21<3855::aid-pola20>3.3.co;2-u

Cited by 48 publications

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“…Another interesting feature of this technique is the possibility of achieving something similar to the gel effect that can be seen in bulk polymerization. [19] In a dispersion polymerization, the propagation may proceed simultaneously in the solution and particle phases. When growing oligomer radicals are captured by the particles the high viscosity inside the particles will reduce the termination rate, and hence, the molar mass will increase.…”

Section: Preparing Polymers With Different Molar Massesdispersion Polmentioning

confidence: 71%

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Synthesis of Novel Monomers and Copolymers from 1‐Vinylpyrrolidin‐2‐one: Attractive Materials for Drug Delivery Systems?

Engström

Lindgren

Helgee

2006

Macro Chemistry & Physics

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Summary: Polyvinylpyrrolidone (PVP) is a synthetic, non‐toxic, water‐soluble polymer commonly used in a wide range of applications including several pharmaceutical applications. One example of an important application is the controlled release and delivery of therapeutic agents into sites of inflammation or tumours. However, PVP lacks reactive groups, which limits the possibility of adding new functions to the polymer in order to modify its physical and chemical properties. Furthermore, large differences in radical reactivity between 1‐vinylpyrrolidin‐2‐one (NVP) and most other monomers lead to compositional drift during copolymerization. This complicates the introduction of reactive groups into the polymer using this method. Monomers that are derivatives of NVP itself are expected to show smaller differences in radical reactivity and therefore provide a way of preparing PVP with adjustable properties. Here we present the synthesis of five NVP‐based monomers and their use in the preparation of functional PVP with adjustable properties in terms of solubility, loading of functional groups, and molar mass. The results show the possibility of tailoring PVP for different biomedical applications e.g. drug delivery systems.Copolymers from 1‐vinylpyrrolidin‐2‐one.magnified imageCopolymers from 1‐vinylpyrrolidin‐2‐one.

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Section: Preparing Polymers With Different Molar Massesdispersion Polmentioning

confidence: 71%

“…In these experiments a modified version of a published procedure was used. [19] The chromatogram from the homopolymerization of NVP (polymer I), is shown in Figure 3 together with polymer H from the solution polymerization in benzene, and polymer K from the bulk polymerization.…”

Section: Preparing Polymers With Different Molar Massesdispersion Polmentioning

confidence: 99%

Synthesis of Novel Monomers and Copolymers from 1‐Vinylpyrrolidin‐2‐one: Attractive Materials for Drug Delivery Systems?

Engström

Lindgren

Helgee

2006

Macro Chemistry & Physics

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“…The diameters measured by DLS are larger than those determined by SEM since the former technique determines the diameter of solvent-swollen particles, whereas the latter measures particles in the dry state. 16 At the end of the polymerization, the particle diameter is ca. 350 nm as determined by SEM, while the DLS determined diameter is ca.…”

Section: Kinetics Studymentioning

confidence: 99%

Size Shrinkage of Methacrylate-based Terpolymer Latexes Synthesized by Free Radical Polymerization: Kinetics and Influence of Main Reaction Parameters

Armini

Whelan

Smet

et al. 2006

Polym J

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ABSTRACT:Monodisperse PMMA-based terpolymer particles were synthesized by surfactant-free free radical emulsion polymerization. Particles with a wide and controllable range of size and polymer content were prepared by varying monomer amount, reaction temperature and initiator concentration. A kinetic study of the evolution of the terpolymer colloid composition and morphology reveals a mechanism of fast homogeneous nucleation. Copolymerization of the three monomers yields particles whose composition changes continuously during the reaction, which impacts polymer properties. Temperature and monomer amount are key parameters, particularly in the nucleation and growth stages of the reaction. A linear relationship between the particle size and reaction temperature is observed. This is attributed to the fact that the concentration of small, nucleated primary particles with high surface area, initiated at higher temperatures, is too large for efficient stabilization and hence they are more prone to aggregation. The linear relationship between the volume of the colloids and the ratio of main monomer to water in the reaction batch is due to the growth of the particles that continues while there is MMA available. The initiator concentration is not significant in terms of size and concentration of methacrylate-based colloids since primary particles are formed very early during polymerization and they are not dependent on the number of growing chains. The resulting ''tailor-made'' latexes are promising for a number of unique biotechnological and IC manufacturing applications.

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“…The difference in the diameters measured by TEM and light scattering is due to the fact that the first method measures the dry diameter of the nanoparticles while the second one measures the hydrodynamic diameter, which takes into account also the surface adsorbed solvent (water) molecules. [25] Figure 2 describes the general scheme through which covalent and physical conjugation of thrombin onto the surface of the g-Fe 2 O 3 nanoparticles have been performed. These nanoparticles contain gelatin within and on the surface of the nanoparticles.…”

Section: Effect Of the Specific Inhibitor Antithrombin III On The Clomentioning

confidence: 99%

Synthesis and Characterization of Thrombin Conjugated γ‐Fe₂O₃ Magnetic Nanoparticles for Hemostasis

Lublin-Tennenbaum

Margel

2009

Adv Eng Mater

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Thrombin is the final protease produced in the clotting pathways. Thrombin has been used in the clinic more than six decades for topical hemostasis and wound management. In human plasma the half‐life of thrombin is shorter than 15 seconds due to close control by inhibitors. In order to stabilize thrombin, this enzyme was conjugated covalently and physically to γ‐Fe2O3 magnetic nanoparticles. The physical conjugation was accomplished through adsorption of thrombin to BSA coating on the nanoparticles. The coagulant activity of the covalently bound thrombin was significantly lower than that of the physically adsorbed thrombin. Leakage of the physically bound thrombin into PBS containing 4% HSA was negligible. The physical conjugation of thrombin onto the nanoparticles stabilized the thrombin against its major inhibitor antithrombin III and improved its storage stability. At optimal CaCl2 concentration, the clotting time by the bound thrombin is shorter than that of the free enzyme. This novel conjugated thrombin may be an efficient candidate for topical hemostasis and wound healing.

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Reactive poly(glycidyl methacrylate) microspheres prepared by dispersion polymerization

Cited by 48 publications

References 0 publications

Synthesis of Novel Monomers and Copolymers from 1‐Vinylpyrrolidin‐2‐one: Attractive Materials for Drug Delivery Systems?

Synthesis of Novel Monomers and Copolymers from 1‐Vinylpyrrolidin‐2‐one: Attractive Materials for Drug Delivery Systems?

Size Shrinkage of Methacrylate-based Terpolymer Latexes Synthesized by Free Radical Polymerization: Kinetics and Influence of Main Reaction Parameters

Synthesis and Characterization of Thrombin Conjugated γ‐Fe₂O₃ Magnetic Nanoparticles for Hemostasis

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Reactive poly(glycidyl methacrylate) microspheres prepared by dispersion polymerization

Cited by 48 publications

References 0 publications

Synthesis of Novel Monomers and Copolymers from 1‐Vinylpyrrolidin‐2‐one: Attractive Materials for Drug Delivery Systems?

Synthesis of Novel Monomers and Copolymers from 1‐Vinylpyrrolidin‐2‐one: Attractive Materials for Drug Delivery Systems?

Size Shrinkage of Methacrylate-based Terpolymer Latexes Synthesized by Free Radical Polymerization: Kinetics and Influence of Main Reaction Parameters

Synthesis and Characterization of Thrombin Conjugated γ‐Fe2O3 Magnetic Nanoparticles for Hemostasis

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Synthesis and Characterization of Thrombin Conjugated γ‐Fe₂O₃ Magnetic Nanoparticles for Hemostasis