Most existing research on advanced economic activities focuses on either inner-city milieus or suburban industrial parks. We contend, however, that residential neighbourhoods constitute a milieu for economic activities which require the input of high-skilled labour or, to follow Allen Scott, cognitive-cultural activities which are characteristic for contemporary urban economies.Based on a longitudinal data set of company-level data, we show that a significant share of economic activities in urban residential neighbourhoods can indeed be classified as cognitivecultural and that this share has been growing over the period [1999][2000][2001][2002][2003][2004][2005][2006][2007][2008]. We present an analysis of the spatiality of the embeddedness of these activities. In particular, we focus on their traded and untraded interdependencies. For this part of the analysis we use survey-data of 370 businesses based in Dutch residential neighbourhoods. Overall, cognitive-cultural activities maintain many untraded interdependencies on a local level, whereas they maintain most traded interdependencies on a supra-local level. They appear to be making frequent use of both local buzz as well as of supralocal 'pipelines', and are thus embedded on various spatial scales. Residential neighbourhoods, then, have to be taken more seriously not just as places of consumption but also as milieus of production for more advanced economic activities.