Real Life Impact of Dry Eye Disease

Cutrupi, Francesco; Luca, Andrea De; Zazzo, Antonio Di; Micera, Alessandra; Coassin, Marco; Bombardieri, Stefano

doi:10.1080/08820538.2023.2204931

Cited by 8 publications

(3 citation statements)

References 154 publications

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“…The increasing number of alternative treatments for several severe autoimmune and tumoral diseases has improved the quality of life of patients with these diseases. Side effects and complications related to long-lasting chronic diseases and medications, as well as improved survivorships, have led patients to focus more on symptoms and signs which may limit their normal daily activities by modifying aesthetics and quality of vision [48]. Therefore, uncommon blepharitis, mainly related to systemic and topical treatments of such novel chronic diseases, should be adequately managed by ophthalmologists, since a high number of patients will be affected by such conditions.…”

Section: Discussionmentioning

confidence: 99%

Uncommon Blepharitis

Di Zazzo,

Giannaccare,

Villani

et al. 2024

JCM

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Blepharitis is a common chronic inflammatory condition affecting the eyelid margins; the pathophysiology of blepharitis is complex and not fully understood. The disease is anatomically divided into anterior (inflammation of eyelashes) and posterior (meibomian gland dysfunction) types. Diagnosis relies on clinical examination, revealing characteristic features like scurf, vascular changes, and meibomian gland dysfunction. The main goals of blepharitis treatment are symptom relief, recurrence prevention, and complication risk minimization. Treatment options include lid hygiene, topical and systemic antibiotics, topical corticosteroids, and omega-3 supplements. However, it is important to highlight reported cases of blepharitis as side effects of systemic therapies, particularly in the context of chemotherapy, bortezomib, cetuximab, TNFα inhibitors, and dupilumab. It is crucial to monitor patients undergoing such treatments regularly and attentively in order to promptly set up adequate supportive therapy. Of even more importance is future research on the pathophysiological mechanisms responsible for the occurrence of these ocular side effects in order to find a nosological cure for the issue.

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Section: Discussionmentioning

confidence: 99%

Uncommon Blepharitis

Di Zazzo,

Giannaccare,

Villani

et al. 2024

JCM

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“…Tear film intra-blinking instability worsens the optical quality of the tear film (and then the ocular surface), leading to an intermittent and variable loss of visual quality. Such a condition may be, in severe cases, also described as functional blindness, because affected patients experience a severe limitation in their daily activities, such as driving, sleeping, and working [ 92 ].…”

Section: Clinical Picturementioning

confidence: 99%

One Soul and Several Faces of Evaporative Dry Eye Disease

Di Zazzo,

Barabino,

Fasciani

et al. 2024

JCM

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The ocular surface system interacts with, reacts with, and adapts to the daily continuous insults, trauma, and stimuli caused by direct exposure to the atmosphere and environment. Several tissue and para-inflammatory mechanisms interact to guarantee such an ultimate function, hence maintaining its healthy homeostatic equilibrium. Evaporation seriously affects the homeostasis of the system, thereby becoming a critical trigger in the pathogenesis of the vicious cycle of dry eye disease (DED). Tear film lipid composition, distribution, spreading, and efficiency are crucial factors in controlling water evaporation, and are involved in the onset of the hyperosmolar and inflammatory cascades of DED. The structure of tear film lipids, and subsequently the tear film, have a considerable impact on tears’ properties and main functions, leading to a peculiar clinical picture and specific management.

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“…Dry eye disease is common, with large cross sectional studies estimating a prevalence of 19-31% among the adult population123 and 6-23% among children 4. This condition is often associated with ocular discomfort and visual symptoms, and severity can range from mild occasional discomfort to sight threatening disease 5. This article offers an approach to identifying and managing dry eye disease and discusses novel treatment modalities.…”

mentioning

confidence: 99%

Dry eye disease management

Safir,

Twig,

Mimouni

2024

BMJ

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Real Life Impact of Dry Eye Disease

Cited by 8 publications

References 154 publications

Uncommon Blepharitis

Uncommon Blepharitis

One Soul and Several Faces of Evaporative Dry Eye Disease

Dry eye disease management

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