Real-Time Glucose Sensing Using Transdermal Fluid Under Continuous Vacuum Pressure in Children with Type 1 Diabetes

Burdick, Jonathan; Chase, Peter; Faupel, Mark L.; Schultz, Brenda; Gebhart, Suzanne

doi:10.1089/dia.2005.7.448

Cited by 15 publications

(19 citation statements)

References 15 publications

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“…Table 1 summarises characteristics of the included trials. Five RCTs involving 131 participants met our predefined inclusion criteria [15][16][17][18][19]; the remaining 20 studies were excluded [7,[11][12][13][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Table 2 summarises the characteristics of excluded trials, including reasons for exclusion.…”

Section: Resultsmentioning

confidence: 99%

“…One trial [17] showed an Bode et al [20] Non-randomised, uncontrolled trial Bode et al [7] RCT performed in adults. Guardian Continuous Monitoring System used Boland et al [21] Non-randomised, uncontrolled trial Burdick et al [22] Non-randomised, uncontrolled trial. Real-Time glucose sensing system used Chase et al [23] RCT; GlucoWatch G2 Biographer used Chico et al [24] Non-randomised, uncontrolled trial Deiss et al [25] Non-randomised, uncontrolled trial Deiss et al [26] RCT; Guardian RT system used DirectNet [27] RCT; GlucoWatch G2 Biographer used DirectNet [28] RCT; GlucoWatch G2 Biographer used Fiallo-Scharer et al [29] RCT; GlucoWatch G2 Biographer used Garg et al [30] RCT; DexCom STS system used Halvorson et al [31] Non-randomised, uncontrolled trial.…”

Section: Resultsmentioning

confidence: 99%

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Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis

et al. 2007

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Aims/hypothesis We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. Methods The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Cochrane Library. Additional references were obtained from reviewed articles. Only randomised controlled trials were included. Results We included five trials involving 131 type 1 diabetic patients in the study. Combined data from all trials showed that the CGMS did not significantly reduce HbA 1c levels compared with control groups. The pooled weighted mean difference was −0.02% (95% CI −0.29 to 0.25) with a fixed model and remained insignificant in the random effect model. Sensitivity analysis determined that the findings were stable. There was a trend towards a longer time under the CGMS curve for glucose <3.89 mmol/l in the CGMS group compared with the control group (mean difference 49.00 min, 95% CI −18.00 to 116.00). The CGMS significantly increased the number of insulin dose changes per patient per month for those managed with CGMS compared with the control groups (mean difference 6.3 changes, 95% CI 2.88-9.72). Conclusions/interpretation The Continuous Glucose Monitoring System is not better than self-monitoring of blood glucose with regard to improvement of metabolic control among type 1 diabetic children. However, due to the small number of participants and methodological limitations of the studies included, findings of this meta-analysis should be interpreted with caution.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis

et al. 2007

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“…In the other studies evaluating this system, 21 adverse events were reported in 16 patients, which were all mild and resolved within 7 days, 93 and four adverse events were considered 'probably related' to monitor use. 45 In a study 94 of an experimental real-time glucose sensing system, three participants (3%) had a skin reaction to the adhesive that resolved spontaneously. In the DirecNet study 54 of the FreeStyle Navigator most of the participants tolerated the sensor well, although two had severe skin reactions related to the adhesive.…”

Section: Other Continuous Glucose Monitoring Devicesmentioning

confidence: 99%

A randomised controlled trial to compare minimally invasive glucose monitoring devices with conventional monitoring in the management of insulin-treated diabetes mellitus (MITRE)

Newman

Cooke²,

Casbard³

et al. 2009

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable CD-ROM is also available (see below).Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in t...

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“…Consequently, the circulating IGF-I system may provide both an assessment and prognostic value in metabolic and body composition monitoring (15,20). However, the local biochemical milieu may provide better information about cellular metabolic events regulated by those growth factors than measurements of circulating concentrations because many growth factors, including IGF-I, are also secreted from cells and act in an autocrine/paracrine manner (6,11,12,21).…”

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confidence: 99%

“…Recent advances in biotechnology have led to the development of noninvasive technologies for the purpose of continuous monitoring of glucose in TDF, and correlations ranging from 0.87 to 0.95 between blood and TDF glucose have been reported (6,11). In addition to glucose, growth factors useful for physiological monitoring have been observed in TDF as well (e.g., IGF-I, IGF-II, IGFBP), but their representation of physiological status is unclear (29).…”

mentioning

confidence: 99%

A novel, noninvasive transdermal fluid sampling methodology: IGF-I measurement following exercise

Scofield

McClung

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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This study tested the hypothesis that transdermal fluid (TDF) provides a more sensitive and accurate measure of exercise-induced increases in insulin-like growth factor-I (IGF-I) than serum, and that these increases are detectable proximal, but not distal, to the exercising muscle. A novel, noninvasive methodology was used to collect TDF, followed by sampling of total IGF-I (tIGF-I) and free IGF-I (fIGF-I) in TDF and serum following an acute bout of exercise. Experiment 1: eight men (23 ± 3 yrs, 79 ± 7 kg) underwent two conditions (resting and 60 min of cycling exercise at 60% Vo(2)(peak)) in which serum and forearm TDF were collected for comparison. There were no significant changes in tIGF-I or fIGF-I in TDF obtained from the forearm or from serum following exercise (P > 0.05); however, the proportion of fIGF-I to tIGF-I in TDF was approximately fourfold greater than that of serum (P ≤ 0.05). These data suggest that changes in TDF IGF-I are not evident when TDF is sampled distal from the working tissue. To determine whether exercise-induced increases in local IGF-I could be detected when TDF was sampled directly over the active muscle group, we performed a second experiment. Experiment 2: fourteen subjects (22 ± 4 yr, 68 ± 11 kg) underwent an acute plyometric exercise condition consisting of 10 sets of 10 plyometric jumps with 2-min rest between sets. We observed a significant increase in TDF tIGF-I following exercise (P ≤ 0.05) but no change in serum tIGF-I (P > 0.05). Overall, these data suggest that TDF may provide a noninvasive means of monitoring acute exercise-induced changes in local IGF-I when sampled in proximity to exercising muscles. Moreover, our finding that the proportion of free to tIGF-I was greater in TDF than in serum suggests that changes in local IGF-I may be captured more readily using this system.

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Real-Time Glucose Sensing Using Transdermal Fluid Under Continuous Vacuum Pressure in Children with Type 1 Diabetes

Cited by 15 publications

References 15 publications

Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis

Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis

A randomised controlled trial to compare minimally invasive glucose monitoring devices with conventional monitoring in the management of insulin-treated diabetes mellitus (MITRE)

A novel, noninvasive transdermal fluid sampling methodology: IGF-I measurement following exercise

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