Real-time interlaced ultrasound and photoacoustic system for<i>in vivo</i>ovarian tissue imaging

Alqasemi, Umar; Hai, Li; Yuan, Guangqian; Kumavor, Patrick D.; Zanganeh, Saeid; Zhu, Quing

doi:10.1117/12.2008273

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gore & Associates Inc., Newark, Delaware) having 120% and 80% fractional bandwidths, respectively, were used depending on the target size and depth. The PAT data were collected by a home-made system, 40,41 which is capable of performing real-time PAT and ultrasound data collection and display. The system consists of eight 16-channel customized modules combined to form a 128channel system.…”

Section: Introductionmentioning

confidence: 99%

Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography

Chen¹,

Kumavor²,

Alqasemi³

et al. 2013

J. Biomed. Opt

Self Cite

View full text Add to dashboard Cite

To overcome the intensive light scattering in biological tissue, diffuse optical tomography (DOT) in the near-infrared range for breast lesion detection is usually combined with other imaging modalities, such as ultrasound, x-ray, and magnetic resonance imaging, to provide guidance. However, these guiding imaging modalities may depend on different contrast mechanisms compared to the optical contrast in the DOT. As a result, they cannot provide reliable guidance for DOT because some lesions may not be detectable by a nonoptical modality but may have a high optical contrast. An imaging modality that relies on optical contrast to provide guidance is desirable for DOT. We present a system that combines a frequency-domain DOT and real-time photoacoustic tomography (PAT) systems to detect and characterize deeply seated targets embedded in a turbid medium. To further improve the contrast, the exogenous contrast agent, indocyanine green (ICG), is used. Our experimental results show that the combined system can detect a tumor-mimicking phantom, which is immersed in intralipid solution with the concentrations ranging from 100 to 10 μM and with the dimensions of 0.8 cm × 0.8 cm × 0.6 cm, up to 2.5 cm in depth. Mice experiments also confirmed that the combined system can detect tumors and monitor the ICG uptake and washout in the tumor region. This method can potentially improve the accuracy to detect small breast lesions as well as lesions that are sensitive to background tissue changes, such as the lesions located just above the chest wall.

show abstract

Section: Introductionmentioning

confidence: 99%

Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography

Chen¹,

Kumavor²,

Alqasemi³

et al. 2013

J. Biomed. Opt

Self Cite

View full text Add to dashboard Cite

show abstract

“…Amongst them, integration of hybrid optical imaging techniques such as photoacoustic (PA) imaging with other optical imaging modalities or with complementary imaging modalities such as ultrasound (US) imaging has gained considerable interest and a few have been already reported. These include dual modality imaging systems such as combined PA -US [6][7][8][9][10][11][12][13][14], PAI -diffuse optical tomography (DOT) [15,16], PAfluorescence imaging or confocal microscopy [17][18][19] and PA -optical coherence tomography (OCT) [20][21][22][23][24]. Further, PA based tri-modal imaging systems such as integrated OCT, PA and US [25], integrated PA, US and thermoacoustic (TA) [26,27] and integrated PA, US and elasticity imaging [28][29][30] have been also reported.…”

Section: Introductionmentioning

confidence: 99%

Integrated photoacoustic, ultrasound and fluorescence platform for diagnostic medical imaging-proof of concept study with a tissue mimicking phantom

Joseph¹,

Murukeshan²,

Woh³

2014

Biomed. Opt. Express

View full text Add to dashboard Cite

The structural and molecular heterogeneities of biological tissues demand the interrogation of the samples with multiple energy sources and provide visualization capabilities at varying spatial resolution and depth scales for obtaining complementary diagnostic information. A novel multi-modal imaging approach that uses optical and acoustic energies to perform photoacoustic, ultrasound and fluorescence imaging at multiple resolution scales from the tissue surface and depth is proposed in this paper. The system comprises of two distinct forms of hardware level integration so as to have an integrated imaging system under a single instrumentation set-up. The experimental studies show that the system is capable of mapping high resolution fluorescence signatures from the surface, optical absorption and acoustic heterogeneities along the depth (>2cm) of the tissue at multi-scale resolution (<1µm to <0.5mm).

show abstract

“…They used 128-chanel to acquisition with FPGA for real time imaging of human ovaries up to 15 frames per second. The system is able to detect ovaries' vasculature by in vivo co-registered Photo-acoustic system while it is limited by the laser pulse repetition frequency of 15 HZ [7].…”

Section: Literature Reviewmentioning

confidence: 99%

A Framework of Photo Acoustic Imaging for Ovarian Cancer Detection by Galvo-mirror System

Mahmoodian¹,

Haddadnia²

2016

J Bioengineer & Biomedical

View full text Add to dashboard Cite

Ovarian cancer is one of the most common types of cancer among women, which often leads to death. As a result, developing new techniques for diagnosing this disease at early stages, preventing the high rate of death in women with high-risk, and minimizing the large side effects on the economy must be considered seriously by experts. For early diagnosis of this disease, it is necessary to utilize ultrasound integrated with photo acoustic technique in which the minimal amount of cost, energy, and laser are acquired. In addition, the procedure should provide sufficient pulse to make ovaries tissue able to take image. This new clinical diagnosis technique utilizes modest pulse energy and low electrical voltage so that, it could be assumed as a proper alternative for conventional ultrasound in showing the image of abdominal ovary tissue. The researcher aims at presenting a real time photo acoustic-imaging probe for imaging human ovaries tissue; thus, this study seeks to investigate the effect of low electrical voltage and modest laser pulse energy while providing enough pulse for ovarian tissue as well as implementation issue. This model utilizes dual modality imaging approach and describes several researches carried out in order to establish dual-model imaging consisting ultrasound and photo acoustic. The system can accomplish near-simultaneous ultrasound and photo acoustic imaging. The model is capable of reaching thorough diagnostic information based on the tissue where there is only individual imaging model with its limitations.

show abstract

Real-time interlaced ultrasound and photoacoustic system forin vivoovarian tissue imaging

Cited by 5 publications

References 0 publications

Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography

Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography

Integrated photoacoustic, ultrasound and fluorescence platform for diagnostic medical imaging-proof of concept study with a tissue mimicking phantom

A Framework of Photo Acoustic Imaging for Ovarian Cancer Detection by Galvo-mirror System

Contact Info

Product

Resources

About