Real-time method for motion-compensated MR thermometry and MRgHIFU treatment in abdominal organs

Celicanin, Zarko; Auboiroux,; Bieri, Oliver; Petrusca, Lorena; Santini, Francesco; Viallon, Magalie; Scheffler, Klaus; Salomir, Rarès

doi:10.1002/mrm.25017

Cited by 47 publications

(37 citation statements)

References 31 publications

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“…For example, using the abovementioned spatial resolution and FOV, 3 slices can be imaged when TA = 0.7 s using an ETL of 7 and a TR of 30 ms. It was shown in previous studies that a temporal resolution of 1 s and below can be achieved using EPI sequences during real-time MRI thermometry [40,41]. When this acquisition speed is not important, the additional time can be used to increase resolution, spatial coverage or to add additional functional measurements such as perfusion, flow measurements or blood oxygen level dependent (BOLD) data acquisition.…”

Section: Discussionmentioning

confidence: 96%

Fast PRF-based MR thermometry using double-echo EPI: in vivo comparison in a clinical hyperthermia setting

Dadakova

Gellermann

Voigt

et al. 2014

Magn Reson Mater Phy

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Section: Discussionmentioning

confidence: 96%

Fast PRF-based MR thermometry using double-echo EPI: in vivo comparison in a clinical hyperthermia setting

Dadakova

Gellermann

Voigt

et al. 2014

Magn Reson Mater Phy

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“…Automatic temperature control is not intended to primarily address these issues, which should be corrected using dedicated methods, e.g., see [29] and [30]. The automatic control method described here is compatible with any motion compensation method if its time latency is sufficiently low.…”

Section: Discussionmentioning

confidence: 97%

A Nonparametric Temperature Controller With Nonlinear Negative Reaction for Multi-Point Rapid MR-Guided HIFU Ablation

Petrusca

Auboiroux

Goget

et al. 2014

IEEE Trans. Med. Imaging

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Magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) is a noninvasive method for thermal ablation, which exploits the capabilities of magnetic resonance imaging (MRI) for excellent visualization of the target and for near real-time thermometry. Oncological quality of ablation may be obtained by volumetric sonication under automatic feedback control of the temperature. For this purpose, a new nonparametric (i.e., model independent) temperature controller, using nonlinear negative reaction, was designed and evaluated for the iterated sonication of a prescribed pattern of foci. The main objective was to achieve the same thermal history at each sonication point during volumetric MRgHIFU. Differently sized linear and circular trajectories were investigated ex vivo and in vivo using a phased-array HIFU transducer. A clinical 3T MRI scanner was used and the temperature elevation was measured in five slices simultaneously with a voxel size of 1 ×1 ×5 mm(3) and temporal resolution of 4 s. In vivo results indicated a similar thermal history of each sonicated focus along the prescribed pattern, that was 17.3 ± 0.5 °C as compared to 16 °C prescribed temperature elevation. The spatio-temporal control of the temperature also enabled meaningful comparison of various sonication patterns in terms of dosimetry and near-field safety. The thermal build-up tended to drift downwards in the HIFU transducer with a circular scan.

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“…Considering the abdominal ablation of a patient using extracorporeal HIFU in clinical conditions, respiratory motion would mainly affect the target region, with little or no motion of the rib cage, depending on the posture of the patient [45,46]. Since the acoustic pressure has a smooth spatial profile in the pre-focal region, local motion of the ribs relative to the HIFU beam would not have a significant effect on their accumulated thermal build up.…”

Section: Discussionmentioning

confidence: 99%

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

Petrusca

Salomir

Manasseh

et al. 2015

International Journal of Hyperthermia

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Objective: The aim of this paper is to quantitatively investigate the thermal effects generated by the pre-focal interactions of a HIFU beam with a rib cage, in the context of minimally invasive transcostal therapy of liver malignancies. Materials and methods: HIFU sonications were produced by a phased-array MR-compatible transducer on Turkey muscle placed on a sheep thoracic cage specimen. The thoracic wall was positioned in the pre-focal zone 3.5 to 6.5 cm below the focus. Thermal monitoring was simultaneously performed using fluoroptic sensors inserted into the medullar cavity of the ribs and high resolution MR-thermometry (voxel: 1 Â 1 Â 5 mm 3 , four multi-planar slices). Results: MR-thermometry data indicated nearly isotropic distribution of the thermal energy at the ribs' surface. The temperature elevation at the focus was comparable with the pericostal temperature elevation around unprotected ribs, while being systematically inferior, by more than a factor of four on average, to the intra-medullar values. The spatial profiles of the pericostal and intra-medullar thermal build-up measurements could be smoothly connected using a Gaussian function. The dynamics of the post-sonication thermal relaxation as determined by fluoroptic measurements was demonstrated to be theoretically coherent with the experimental observations. Conclusion: The experimental findings motivate further efforts for the transfer towards clinical routine of effective rib-sparing strategies for hepatic HIFU.

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Real-time method for motion-compensated MR thermometry and MRgHIFU treatment in abdominal organs

Cited by 47 publications

References 31 publications

Fast PRF-based MR thermometry using double-echo EPI: in vivo comparison in a clinical hyperthermia setting

Fast PRF-based MR thermometry using double-echo EPI: in vivo comparison in a clinical hyperthermia setting

A Nonparametric Temperature Controller With Nonlinear Negative Reaction for Multi-Point Rapid MR-Guided HIFU Ablation

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

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