Most existing laser welding process monitoring (LWPM) technologies focus on detecting postprocess defects. However, in sheet metal laser welding applications such as welding of electronic consumer products during mass production, in-process defect detection is more important. In this paper, a compact LWPM system using multi-sensor data fusion to detect in-process defects has been built. This system can collect the time series of plasma intensity, light intensity and temperature data for feature analysis. To verify the system's effectiveness, a plasma-light-temperature dataset has been compiled, which consists of 5,836 samples of nine classes, including one positive class and eight negative classes of typical in-process defects. A multi-sensor data fusion network based on a convolution neural network for in-process defect detection, called IDDNet, has also been proposed. Experimental results have demonstrated that IDDNet can achieve better multi-classification results than the support vector machine, with an overall accuracy of 97.57%. In particular, considering this monitoring process as a binary classification problem, IDDNet can achieve a 99.42% accuracy. Moreover, IDDNet can reach an average speed of 0.79ms per sample on a single GTX 1080ti graphics card, which meets the real-time requirement for industrial production. The proposed LWPM system has been successfully verified in real applications of sheet metal laser welding. INDEX TERMS laser welding process monitoring, in-process defect detection, multi-sensor data fusion, convolution neural network