Recent studies have been focusing on unmanned aircraft systems (UASs) to inspect safety issues in the construction industry. A UAS can monitor a broad range in real time and identify unsafe situations and objects at the jobsite. The related studies mostly focus on technological development, and there are few studies investigating potential performance that can be obtained by implementing UASs in the construction domain. Hence, the main objective of this research is to evaluate the potential of UAS-based construction safety inspection. To achieve the goal, this study developed a system dynamic (SD) model, and scenario analysis was conducted. When compared to the existing methods, the use of a UAS resulted in improved safety inspection performance, reduced possibility of incidents, reduced worker fatigue, and reduced amount of delayed work. The results of this research verified that UAS-based safety inspections can be more effective than existing methods. The results of this study can contribute to the understanding of UAS-based construction safety inspection technologies and the potential of the technology.