Selective stimulation of neuron cells at high spatiotemporal resolution in deep brain is a major goal in neuroscience. [1][2][3] Research indicates that neurons can sense, transduce, and respond to various external stimuli such as electric, magnetic, heat, and mechanical stimuli. [4,5] Unmodified neurons may be stimulated directly to evoke action potentials with external fields, such as deep brain stimulation (DBS), [4] but such techniques lacked specificity and selectivity to individual neurons. To address that, in the so-called "optogenetics," chosen neurons can be selectively inserted with wellcharacterized light sensitive proteins (e.g., opsins) and enabled to respond to light stimulation, while other cells remain silent. [6,7] It enables precise neural manipulation with specific time sequence. [4,5,8] Such advancement of spatial resolution and specificity has made optogenetics a powerful tool in neuroscience, especially in exploring the connection between behavior and neural circuits and in treating brain diseases.However, it usually requires invasive procedures to deliver photons into deep brain regions as skull and brain tissue have strong scattering effects to visible and nearinfrared light which is often used in optogenetics. Practically, one may insert a thin optical fiber into a specific deep brain region for neuron activation, which allows for free moving animal manipulations in vivo. The output light from the fiber, no matter it is single-mode fiber (SMF) or multimode fiber (MMF), is divergent and characterized by a large illumination spot or random speckled pattern at a short distance away from the distal fiber end, which fails to meet the spatial variant of the neurons in the field of view (FOV). Although some groups reported that multitargets from a large FOV could be controlled and monitored via a tapered optical fiber, [9] single-fiber-