2018
DOI: 10.1002/mrm.27597
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Real‐time simultaneous shim and motion measurement and correction in glycoCEST MRI using double volumetric navigators (DvNavs)

Abstract: Purpose CEST MRI allows for indirect detection of molecules with exchangeable protons, measured as a reduction in water signal because of continuous transfer of saturated protons. CEST requires saturation pulses on the order of a second, as well as repeated acquisitions at different offset frequencies. The resulting extended scan time makes CEST susceptible to subject motion, which introduces field inhomogeneity, shifting offset frequencies and causing distortions in CEST spectra that resemble true CEST effect… Show more

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Cited by 28 publications
(39 citation statements)
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“…Thus, the required time is approximately the same as for conventional 1 H‐MRSI, which has already been demonstrated to be applicable in a clinical routine. To further improve the current acquisition protocol, a real‐time frequency drift correction as recently proposed for the MTR asym analysis could be included, although it was not required in this work because the small changes in B 0 at 3 T of about 0.02 ppm during a 20‐minute examination are compensated for by the Lorentzian fitting. For the next step, this acquisition protocol will be used to comprehensively assess the actual clinical relevance of relaxation compensation in CEST‐MRI for various neuro‐oncological clinical questions.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the required time is approximately the same as for conventional 1 H‐MRSI, which has already been demonstrated to be applicable in a clinical routine. To further improve the current acquisition protocol, a real‐time frequency drift correction as recently proposed for the MTR asym analysis could be included, although it was not required in this work because the small changes in B 0 at 3 T of about 0.02 ppm during a 20‐minute examination are compensated for by the Lorentzian fitting. For the next step, this acquisition protocol will be used to comprehensively assess the actual clinical relevance of relaxation compensation in CEST‐MRI for various neuro‐oncological clinical questions.…”
Section: Discussionmentioning
confidence: 99%
“…A limitation of the current study is that possible dynamic changes in the B 0 field (e.g., frequency shifts because of susceptibility changes) cannot be separated out from the effects measured. A possible improvement would be the use of double volumetric navigators before the saturation period, which may allow for both motion and B 0 correction, as recently suggested . Although residual motion contributions can still occur in dynamic scans, such approaches no doubt would lead to improvements.…”
Section: Discussionmentioning
confidence: 99%
“…A possible improvement would be the use of double volumetric navigators before the saturation period, which may allow for both motion and B 0 correction, as recently suggested. 41 Although residual motion contributions can still occur in dynamic scans, such approaches no doubt would lead to improvements.…”
Section: Technical Considerationsmentioning
confidence: 99%
“…Previous studies have evaluated the accuracy of static ∆ B 0 correction of CEST‐weighted maps by multiecho methods, while studies proposing dynamic methods to correct for temporal ∆ B 0 changes have only recently emerged …”
Section: Discussionmentioning
confidence: 99%
“…In the future, the proposed dynamic methods could be additionally combined with real‐time motion correction by extending the navigator to 3D as previously applied in MRI and MRSI . Thereby, artifacts due to motion and B 0 ‐instabilities could be simultaneously mitigated.…”
Section: Discussionmentioning
confidence: 99%