Real Time Three‐Dimensional Echocardiographic Evaluations of Fetal Left Ventricular Stroke Volume, Mass, and Myocardial Strain: In Vitro and In Vivo Experimental Study

Zhu, Meihua; Ashraf, Muhammad; Zhang, Zhijun; Streiff, Cole; Shimada, Eriko; Kimura, Sumito; Schaller, Traci; Song, Xubo; Sahn, David J.

doi:10.1111/echo.12939

Cited by 5 publications

(7 citation statements)

References 54 publications

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“…STE provides deformation information of the LV, which has been reported to be valuable in identifying preclinical or subtle myocardial dysfunction. 14 – 16 , 26 , 30 STE has been used in TAV to evaluate cardiac mechanics in AS and AR patients, which revealed lower deformation in asymptomatic/symptomatic patients with normal LVEF when compared with healthy controls. 17 – 20 Few reports are available on BAV cardiac mechanics, 31 – 33 and none of them reported the subtle mechanical changes based on valvular lesion types.…”

Section: Discussionmentioning

confidence: 99%

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Cardiac Mechanics in Isolated Bicuspid Aortic Valve Disease With Normal Ejection Fraction

Zhang

Zhu

et al. 2015

Medicine

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Aortic stenosis (AS) and aortic regurgitation (AR) are associated with congenital isolated bicuspid aortic valve (BAV) disease. The chronic pressure overload of AS and the volume overload of AR are known to impair the left ventricular function. This study assessed whether two-dimensional speckle tracking echocardiography (2D-STE) is capable of detecting the myocardial dysfunction associated with BAV caused by various aortic valve lesions in patients retaining normal ejection fraction (EF).Thirty-two isolated BAV patients and 20 healthy tricuspid aortic valve (TAV) volunteers were recruited. BAV patients were divided into 4 subgroups based on aortic valvular lesion types: normal function (NF) group, isolated AS group, isolated AR group, and a group who had both AS&AR. Myocardial strain and degree of twist were analyzed and compared between the BAV and TAV groups, as well as between valvular lesion groups and the NF group.Compared with healthy TAV controls, global radial strain (GRS), global circumferential strain (GCS), global longitudinal strain (GLS), and twist angle absolute values were lower in the BAV group (P < 0.05). The AS, AR, and AS&AR groups all demonstrated a significant decrease in GRS and GCS when compared with the TAV group. The AS and AS&AR groups demonstrated lower GLS than the TAV group, and the smallest degree of twist was detected in the AR group. There were no significant differences between the NF and TAV groups. The AR and AS&AR groups demonstrated significant differences in multiple parameters of cardiac mechanics compared with the NF group.2D-STE is able to detect altered cardiac mechanics associated with aortic lesion types in BAV patients with normal EF compared with normal TAV controls, and so can provide valuable information for clinical decision-making.

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Section: Discussionmentioning

confidence: 99%

“…3D-STE with higher temporal resolution would provide superior evaluation of subtle cardiac mechanic dysfunction. 14 , 16 , 30 Future 3D-STE studies on BAV deformation are necessary.…”

Section: Limitationsmentioning

confidence: 99%

Cardiac Mechanics in Isolated Bicuspid Aortic Valve Disease With Normal Ejection Fraction

Zhang

Zhu

et al. 2015

Medicine

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“…The new iSTIC technology acquires high-resolution volumetric images of one cardiac cycle in only 2 s, thus reducing the effects of fetal movement on the image. iSTIC realizes real-time 3D visualization of the fetal heart, which has been shown to have many advantages[24,25,27-29]. In the present study, the iSTIC technique was used to measure right ventricular volume in normal fetuses and to evaluate right ventricular systolic function to provide a new method for more accurate and convenient evaluation of fetal heart function.…”

Section: Introductionmentioning

confidence: 98%

Evaluation of right ventricular volume and systolic function in normal fetuses using intelligent spatiotemporal image correlation

Sun¹,

Cai²,

Xie³

2019

WJCC

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BACKGROUND Heart defects are the most common congenital malformations in fetuses. Fetal cardiac structure and function abnormalities lead to changes in ventricular volume. As ventricular volume is an important index for evaluating fetal cardiovascular development, an effective and reliable method for measuring fetal ventricular volume and cardiac function is necessary for accurate ultrasonic diagnosis and effective clinical treatment. The new intelligent spatiotemporal image correlation (iSTIC) technology acquires high-resolution volumetric images. In this study, the iSTIC technique was used to measure right ventricular volume and to evaluate right ventricular systolic function to provide a more accurate and convenient evaluation of fetal heart function. AIM To investigate the value of iSTIC in evaluating right ventricular volume and systolic function in normal fetuses. METHODS Between October 2014 and September 2015, a total of 123 pregnant women received prenatal ultrasound examinations in our hospital. iSTIC technology was used to acquire the entire fetal cardiac volume with off-line analysis using QLAB software. Cardiac systolic and diastolic phases were defined by opening of the atrioventricular valve and the subsequent closure of the atrioventricular valve. The volumetric data of the two phases were measured by manual tracking and summation of multiple slices and recording of the right ventricular end-systolic volume and the right ventricular end-diastolic volume. The data were used to calculate the right stroke volume, the right cardiac output, and the right ejection fraction. The correlations of changes between the above-mentioned indices and gestational age were analyzed. The right ventricular volumes of 30 randomly selected cases were measured twice by the same sonographer, and the intra-observer agreement measurements were calculated. RESULTS Among the 123 normal fetuses, the mean right ventricular end-diastolic volume increased from 0.99 ± 0.34 mL at 22 wk gestation to 3.69 ± 0.36 mL at 35 +6 wk gestation. The mean right ventricular end-systolic volume increased from 0.43 ± 0.18 mL at 22 wk gestation to 1.36 ± 0.22 mL at 35 +6 wk gestation. The mean right stroke volume increased from 0.62 ± 0.29 mL at 22 wk gestation to 2.33 ± 0.18 mL at 35 +6 wk gestation. The mean right cardiac output increased from 92.23 ± 40.67 mL/min at 22 wk gestation to 335.83 ± 32.75 mL/min at 35 +6 wk gestation. Right ventricular end-diastolic volume, right ventricular end-systolic volume, right stroke volume, and right cardiac output all increased with gestational age and the correlations were linear ( P < 0.01). Right ejection fraction had no apparent correlation with gestational age ( P > 0.05). CONCLUSION Fetal right ventricular vol...

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“…Real-time 3-dimensional echocardiography (3DE) using a matrix array transducer enables the acquisition of the full 3D image of the heart and it provides unprecedented information for the quantification of cardiac function. [10] Real-time 3DE precludes the operator dependency and time-consuming acquisition associated with 2-dimensional echocardiography (2DE). It has also been reported to be able to provide accurate and reproducible volume and myocardial strain values comparable with cardiac magnetic resonance (CMR).…”

Section: Introductionmentioning

confidence: 99%

Assessment of left ventricular function in chronic alcoholics by real-time three-dimensional echocardiography

et al. 2017

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Chronic alcohol consumption may lead to progressive cardiac dysfunction. The aim of this study was to evaluate the feasibility of using real-time 3-dimensional echocardiography (3DE) on assessing left ventricular (LV) function in chronic alcoholics.We classified 92 male alcoholics into mild, moderate, and severe groups; 30 age-matched controls were also recruited. LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF), LV mass (LVM), LV mass index (LVMI), and systolic dyssynchrony index (SDI) were measured by 3DE and 2-dimensional echocardiography (2DE).Compared to the control group, LV volume and mass were higher in the moderate and severe alcoholic groups (P < 0.05). The severe alcoholic (symptomatic) group demonstrated decreased LVEF and increased SDI (detected by 3DE) (P < 0.05).Real-time 3DE can detect the increases of LV volumes and mass in asymptomatic alcoholics, and the changes of LVEF and systolic synchrony index in symptomatic alcoholics.

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Real Time Three‐Dimensional Echocardiographic Evaluations of Fetal Left Ventricular Stroke Volume, Mass, and Myocardial Strain: In Vitro and In Vivo Experimental Study

Abstract: RT3DE is capable of quantifying the SV, LVM, and myocardial strain of fetal-sized hearts under different conditions. This nongated RT3DE may aid the evaluation of fetal cardiac function, providing a superior understanding of the progress of fetal heart disorders.

Cited by 5 publications

References 54 publications

Cardiac Mechanics in Isolated Bicuspid Aortic Valve Disease With Normal Ejection Fraction

Cardiac Mechanics in Isolated Bicuspid Aortic Valve Disease With Normal Ejection Fraction

Evaluation of right ventricular volume and systolic function in normal fetuses using intelligent spatiotemporal image correlation

Assessment of left ventricular function in chronic alcoholics by real-time three-dimensional echocardiography

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