Real-time, Universal Screening for Acute HIV Infection in a Routine HIV Counseling and Testing Population

Pilcher, Christopher D.; McPherson, J. Todd; Leone, Peter A.; Smurzynski, Marlene; Owen-O’Dowd, Judy; Peace-Brewer, Amy L; Harris, J. A.; Hicks, Charles B.; Eron, Joseph J.; Fiscus, Susan A.

doi:10.1001/jama.288.2.216

Cited by 141 publications

(122 citation statements)

References 17 publications

Supporting

Mentioning

119

Contrasting

Order By: Relevance

“…After consent is obtained, a blood sample is drawn and sent to the state laboratory for antibody testing, as well as acute HIV screening. 33 HIV test results are provided in person approximately 2 weeks after the pretest counseling session. During the data collection period, there were two HIV test counselors at the local health department, both of similar demographics (Caucasian females, mid 30s).…”

Section: Settingmentioning

confidence: 99%

Risk Behavior Disclosure During HIV Test Counseling

Torrone

Thomas

Maman

et al. 2010

AIDS Patient Care and STDs

View full text Add to dashboard Cite

Individualized risk assessments during HIV testing are an integral component of prevention counseling, a currently recommended behavioral intervention for patients in high-risk settings. Additionally, aggregate risk assessment data are the source of aggregate behavioral statistics that inform prevention programs and allocation of resources. Consequently, inaccurate or incomplete risk behavior disclosure during test counseling may impact the efficacy of the counseling intervention, as well as bias aggregate behavioral statistics. To quantify clientreported accuracy during the risk assessment and identify barriers and facilitators to risk behavior disclosure, we interviewed young men accessing HIV testing services in a southeastern United States city using mixed methodology. Data were collected from August 2007 to April 2008. Based on data collected via an audio and computer-assisted self-interview (n ¼ 203), over 30% of men reported that they were not accurate during the risk assessment. Participants reported numerous interpersonal facilitators to complete disclosure. During qualitative interviews (n ¼ 25), participants revealed that many did not understand the purpose of the risk assessment. Findings suggest that risk assessments completed during HIV test counseling may be incomplete. Modifications to the risk assessment process, including better explaining the role of the risk assessment in prevention counseling, may increase the validity of the data.

show abstract

Section: Settingmentioning

confidence: 99%

Risk Behavior Disclosure During HIV Test Counseling

Torrone

Thomas

Maman

et al. 2010

AIDS Patient Care and STDs

View full text Add to dashboard Cite

show abstract

“…14, S2). Pooling strategies for HIV detection in clinical testing have recently been piloted in Swiss (15), Indian (16), and US (14) clinical-HIV-testing populations. The results suggest that HIV RNA testing -if based on pooling of antibody-negative specimens -can efficiently identify acute HIV infections in clinical testing.…”

mentioning

confidence: 99%

“…Especially in clinicaltesting populations expected to contain low numbers of acute, antibody-negative infections, pooling affords remarkable increases in cost efficiency and predictive value. Clinical studies have clearly indicated that voluntary counseling and testing (VCT) enhanced to incorporate HIV RNA screening can be both clinically (14) and economically feasible (14,16).…”

mentioning

confidence: 99%

Acute HIV revisited: new opportunities for treatment and prevention

Pilcher¹,

Eron²,

Galvin³

et al. 2004

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

Inability to recognize incident infection has traditionally limited both scientific and public health approaches to HIV disease. Recently, some laboratories have begun adding HIV nucleic acid amplification testing to HIV diagnostic testing algorithms so that acute (antibody-negative) HIV infections can be routinely detected within the first 1–3 weeks of exposure. In this review article, we will highlight critical opportunities for HIV treatment and prevention that are presented by these diagnostic strategies

show abstract

“…Pooled plasma has been shown to allow for the identification of patients in the acute phase of disease [6][7][8] . Since individual HIV RNA testing is expensive, a preliminary test of a mixture of plasma (pool) from different individuals could be performed.…”

Section: Patients With Incident Human Immunodeficiency Virus (Hiv)mentioning

confidence: 99%