Fixed and rotary-wing unmanned aircraft systems (UASs), originally developed for military purposes, have widely spread in scientific, civilian, commercial, and recreational applications. Among the most interesting and challenging aspects of small UAS technology are endurance enhancement and autonomous flight; i.e., mission management and control. This paper proposes a practical method for estimation of true and calibrated airspeed, Angle of Attack (AOA), and Angle of Sideslip (AOS) for small unmanned aerial vehicles (UAVs, up to 20 kg mass, 1200 ft altitude above ground level, and airspeed of up to 100 knots) or light aircraft, for which weight, size, cost, and power-consumption requirements do not allow solutions used in large airplanes (typically, arrays of multi-hole Pitot probes). The sensors used in this research were a static and dynamic pressure sensor (“micro-Pitot tube” MPX2010DP differential pressure sensor) and a 10 degrees of freedom (DoF) inertial measurement unit (IMU) for attitude determination. Kalman and complementary filtering were applied for measurement noise removal and data fusion, respectively, achieving global exponential stability of the estimation error. The methodology was tested using experimental data from a prototype of the devised sensor suite, in various indoor-acquisition campaigns and laboratory tests under controlled conditions. AOA and AOS estimates were validated via correlation between the AOA measured by the micro-Pitot and vertical accelerometer measurements, since lift force can be modeled as a linear function of AOA in normal flight. The results confirmed the validity of the proposed approach, which could have interesting applications in energy-harvesting techniques.