Real‐world application of a fast stool <scp>DNA</scp> test for colorectal cancer screening in primary screening positive population

Zhu, Yu; Zhao, Guodong; Ma, Weihua; Chen, Xinmin; Chen, Xiaofei; Li, Danning; Zhao, Shuyan; Xiong, Shangmin; Zheng, Minxue

doi:10.1002/cam4.5521

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…This cross-sectional study, which included 24,613 subjects with a positive rate of FOBT or HRFQ of 28.5% in CRC screening, examined the relation between changeable risk factors and the high-risk rate of CRC utilizing the IPTW method based on propensity scores, which produced less biased effect estimates than the conventional correction procedure. 16 Compared to other developed cities in China like Shanghai (29%), Guangzhou (16.77%), and Tianjin (5.57%), [17][18][19] as well as developed country like Germany (12.0%) and France (6.2%), 20,21 the present results suggest that the detection rate of CRC high-risk in permanent residents of Shenzhen was relatively high, and the prevention of CRC is facing great challenges, and it was also of great significance for improving the health literacy level. The risk variables derived from the IPTW included six well-known modifiable factors (smoking and drinking status, obesity, red and processed meat) that were excluded in the present CRC screening methods.…”

Section: Discussionmentioning

confidence: 99%

Modifiable Risk Factors in High-Risk Groups of Colorectal Cancer Screening: A Cross-Sectional Study with Propensity Score Method

Zhong,

Feng,

Ouyang

et al. 2023

RMHP

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Aim The rising incidence and death rate of colorectal cancer (CRC) have posed a severe danger to the lives and health of residents. Individuals at high risk of CRC are drawing growing attention as the majority of the population impacted by CRC. Hence, it is imperative to examine the detection rates and modifiable factors affecting the populations at high risk for CRC in Shenzhen. Methods The multi-stage stratified cluster sampling method was used to select residents aged 45–74 years old from September 2020 to December 2021. The community-based CRC screening was attended by a total of 30,921 residents from urban and suburb regions. The association between modifiable risk factors and the detection rate of high-risk groups was analyzed using multinomial logistic regression with the inverse probability treatment weighting (IPTW) based on the propensity score. Results The cross-sectional analysis included 24,613 people after excluding 6308 people who had missing or invalid fecal occult blood test (FOBT) results. The detection rate for high-risk groups during CRC screening was 28.50%. Higher rate of high-risk groups was detected among those who were male, aged 60 or above, college or above, other marital status, and living in urban ( P < 0.05). Demographic characteristics after IPTW showed a weak correlation coefficient with the detection rate of CRC high-risk both in high-risk and general-risk groups (SMD < 0.1), suggesting a balanced group of participants. The results of logistic regression with IPTW indicated that smoking, drinking, obesity, lack of exercise, vegetable or fruit eating infrequently, red meat, processed meat, cereal food and their clustering status were more inclined to be risk indicators of CRC ( P < 0.05). Conclusion The detection rate for high-risk CRC groups was comparatively high in Shenzhen. The distribution characteristics of lifestyle and dietary risk factors of high-risk groups should be given consideration when adopting individualized intervention measures and comprehensive prevention and control strategies.

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Section: Discussionmentioning

confidence: 99%

Modifiable Risk Factors in High-Risk Groups of Colorectal Cancer Screening: A Cross-Sectional Study with Propensity Score Method

Zhong,

Feng,

Ouyang

et al. 2023

RMHP

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Real‐world application of a fast stool DNA test for colorectal cancer screening in primary screening positive population

Zhu

Zhao

et al. 2022

Cancer Medicine

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Real‐world application of a fast stool DNA test for colorectal cancer screening in primary screening positive population

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 52 publications

Modifiable Risk Factors in High-Risk Groups of Colorectal Cancer Screening: A Cross-Sectional Study with Propensity Score Method

Modifiable Risk Factors in High-Risk Groups of Colorectal Cancer Screening: A Cross-Sectional Study with Propensity Score Method

Real‐world application of a fast stool DNA test for colorectal cancer screening in primary screening positive population

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